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BBA Advances
Scopus
ISSN 2667-1603 · Elsevier · 168 artikel di indeks
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Artikel Jurnal
Deciphering a mechanistic basis for the pathological effect of the GNAO1 E246K variant in neurodevelopmental disorder
Pathogenic variants in the GNAO1 gene, which encodes for Gαo, a major neuronal G protein, are associated with neurodevelopmental disorders, epilepsy, and movement disorders. We identified and characterized in detail a de novo heterozygous GNAO1 E246K pathogenic variant in an Israeli female infant…
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Artikel Jurnal
Adjacent domains drive the emergence of misfolded intermediates in the folding pathway of the PDZ4 from MAGI1
Protein misfolding in multidomain assemblies emerges from a complex interplay between intra- and interdomain interactions. Here, we dissect how neighboring domains shape the folding and misfolding of the PDZ4 domain from the scaffold protein MAGI1. Exploiting the single intrinsic tryptophan in…
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Artikel Jurnal
Mitochondrial convergence of ferroptosis and cuproptosis in castration-resistant prostate cancer: From metabolic vulnerabilities to therapeutic targeting
Castration-resistant prostate cancer (CRPC) represents the lethal stage of prostate cancer progression and is characterized by persistent therapeutic adaptation, androgen receptor (AR) signaling rewiring, and profound metabolic reprogramming. In recent years, ferroptosis and cuproptosis, two forms…
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Artikel Jurnal
Dynamic changes and roles of LYVE-1 during lipopolysaccharide-induced ALI/ARDS in mice
Background: Lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1) has been recognized as a marker of lymphatic vessels; however, recent studies have reported that LYVE-1 is expressed in diverse cell types and functionally contributes to organ repair. Herein, we examined the expression pattern…
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Artikel Jurnal
Inhibitors of phosphodiesterase 1 enhance paclitaxel cytotoxicity in a MDA-MB-231-derived cell line by promoting microtubule stabilization
Resistance of tumor cells to chemotherapy remains a critical obstacle to effective cancer treatment. Although paclitaxel is one of the most commonly used chemotherapeutic agents for treating triple-negative breast cancer (TNBC), the mechanisms underlying paclitaxel resistance are not fully…
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Artikel Jurnal
CEMIP promotes gefitinib resistance in lung cancer with EGFR-mutation possibly through forming a stable complex CEMIP/c-MYC
While gefitinib greatly improves the prognosis of lung cancer patients with epidermal growth factor receptor (EGFR) mutation, its inevitable resistance severely diminishes therapeutic efficacy. Cell migration-inducing protein (CEMIP) might interact with cellular MYC proto-oncogene (c-MYC) to…
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Artikel Jurnal
Understanding glycan structure and function through artificial intelligence
Glycoinformatics has entered the artificial intelligence era. Stymied by a lack of big data, high sequence complexity, and biosynthetic dependencies, the application of machine learning to glycomics data has largely emerged this decade. In this mini-review, we explore the latest groundbreaking…
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Artikel Jurnal
Lipidomic profiling of Arabidopsis chloroplast protein phosphatase SLP1 mutants reveals altered diurnal lipid remodeling
Lipids are fundamental to the biology of all organisms, including the functioning of subcellular organelles. The plant chloroplast is the site of photosynthesis and serves as a hub of metabolic events that are dynamically regulated between the light and dark periods. The regulation of chloroplast…
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Toward spatial glycomics and glycoproteomics: Innovations and applications
In this mini review, we provide an overview of the challenging field of spatial glycomics/glycoproteomics. Owing to their complexity, sophisticated analytical methods and innovative technologies are needed to advance this field. An agile development approach enables unraveling aberrant…
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Artikel Jurnal
Identification of aberrant α-2,3 sialylation of cartilage associated with osteonecrosis of the femoral head based on integrated multi-omics analyses
Purpose: Osteonecrosis of the femoral head (ONFH) is one of the most common and devastating articular cartilage diseases worldwide. The role of glycosylation in cartilage degeneration of ONFH is not yet fully understood. Patients and methods: The expression of glycogens in cartilage from ONFH…
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Artikel Jurnal
CaF2 nanoparticles deliver siRNA targeting STAT6 and PPAR- γ to depolarise tumour-associated macrophages
Breast cancer is a leading cause of death in women, partly due to challenges posed by constituents of the tumour-microenvironment, such as tumour-associated macrophages (TAMs). Polarisation of macrophages to a pro-tumour phenotype usually involves STAT6 and PPAR- γ pathways. In this study, CaF2…
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Artikel Jurnal
Albumin does not induce IL-6 release and toll-like receptor activation in vitro: Role of endotoxin contamination and biochemical modifications
Human serum albumin (HSA) is widely used in both clinical and research settings, yet its potential to stimulate immune responses remains poorly understood. In this study, we systematically investigated various therapeutic, recombinant and plasma-derived albumin preparations for their ability to…
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VDAC1 inhibitor DIDS uncouples respiration in isolated tissue mitochondria and induces mitochondrial hyperfusion in mammalian cells
Mitochondrial outer membrane protein, voltage-dependent anion channel 1 (VDAC1), is a gatekeeper of transport, metabolism, and cellular apoptosis. Ablation of VDAC1 or treatment with small molecular VDAC1 inhibitors often causes metabolic reprogramming in cells. However, the mechanism of…
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Artikel Jurnal
Isonardosinone suppresses osteoclastogenesis through TRAF2/TRAF6-mediated disruption of calcium signaling and coordinate inhibition of MAPK/NF-κB pathways
Background: Osteoporosis (OP), a prevalent age-related skeletal disorder, is characterized by increased osteoclast (OC) activity, leading to bone loss, reduced bone mineral density, and elevated fracture risk. Through combined in vivo and in vitro experiments, this study aimed to elucidate the…
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Therapeutic potential of 7-oxo-DHEA as an adjunctive host-directed therapy for pulmonary tuberculosis
Although anti-tuberculous therapy effectively eradicates Mycobacterium tuberculosis (Mtb) infection, it requires prolonged treatment with multiple drugs, often resulting in adverse effects and poor compliance. Therefore, novel immunotherapeutic strategies are needed to enhance host defense and…
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Artikel Jurnal
Unravelling lipid heterogeneity: Advances in single-cell lipidomics in cellular metabolism and disease
Recent advancements in single-cell analysis have revolutionized our understanding of cellular heterogeneity, particularly in lipid metabolism. Single-cell lipidomics, enabled by ultra-sensitive mass spectrometry techniques such as Orbitrap and Fourier-transform ion cyclotron resonance (FT-ICR)…
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Blending salmon gelatin with polyvinylidene fluoride using coaxial electrospinning
Electrospinning is a technique that produces large quantities of nanofibers, that can be designed at the molecular level. Electrospun membranes can be designed to biomimic the chemical composition and morphological structure of the extracellular matrix. Here, we blend salmon gelatin with polyvinyl…
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F-type lectins: Structural and functional aspects, and potential biomedical applications
Among the multiple animal lectin families recognized to date, F-type lectins (FTLs), fucose-binding lectins characterized by an FTL domain (FTLD), constitute the most recent lectin family to be identified and structurally characterized. The structure of the FTL from the European eel Anguilla…
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Artikel Jurnal
Phosphorylation of the fission protein Drp1 contributes to the impact of the curcuminoid 1,7-bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one on mitochondrial and cellular processes
Curcumin and its curcuminoid derivatives extracted from turmeric have been investigated for their potential therapeutic benefits in cancer treatment. Curcuminoids 1,7-bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one and bisdemethoxycurcumin can be obtained from Alpinia galangal. Despite their similar…