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Fundamental Research
Scopus
ISSN 2667-3258 · KeAi Communications Co. Ltd. · 1.023 artikel di indeks
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Artikel Jurnal
Application of stellate ganglion modulation in mental disorders and the future prospects of physical therapies
The treatment of mental disorders faces significant challenges due to their complex etiology and the limitations of existing therapies. Neuromodulation has emerged as a promising approach for managing these conditions. Among the various neuromodulatory strategies, stellate ganglion modulation (SGM)…
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Artikel Jurnal
Harnessing multi-omics and machine learning for predicting immune checkpoint blockade responses: Advances, challenges, and future directions
Immune checkpoint blockade (ICB) therapies have revolutionized cancer treatment, showing success across various cancer types. However, there is variability in response rates among different cancers and individual patients. This highlights the critical need for precise patient stratification…
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Biointerface interaction regulation based on organic semiconducting polymers
In complex biological systems, physical factors such as light and thermal energy affect normal physiological processes. When exposed to light stimulation, organic semiconducting polymers (OSPs) alter their physical/chemical properties through unique energy conversion capabilities, thereby…
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Rethinking structural safety for a volatile century
Most structural design frameworks remain rooted in outdated assumptions: that hazards occur in isolation, materials do not degrade, and failure can be prevented through overdesign. In an era marked by accelerating climate volatility, cascading disasters, and mounting carbon constraints, such logic…
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Artikel Jurnal
Rendering compact formation and trajectory tracking for cyber unmanned ground vehicles
This paper considers the cooperative control problem for the unmanned ground vehicle swarm system with cyber interference. Each vehicle in the system is intelligent and connected with each other via networks. The cyber security issue is inevitable and vital in the control design for the swarm…
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Artikel Jurnal
Disruption of the nucleocapsid-RNA condensation by punicalagin is a broad-spectrum antiviral approach
The formation of liquid condensates by nucleocapsid (N) protein and viral RNA is a critical and highly conserved event in the life cycle of numerous viruses. Targeting this process emerges as a possible strategy to combat viral infections. Here, we discover that punicalagin, a natural compound…
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MULGONET: An interpretable neural network framework to integrate multi-omics data for cancer recurrence prediction and biomarker discovery
Multi-omics cancer data provides complementary views of tumorigenesis and progression. Technical challenges exist in integrating these heterogeneous data into deep learning models to better understand tumorigenesis and predict cancer recurrence. We herein propose a novel end-to-end deep learning…
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Decoding intrinsically disordered regions in biomolecular condensates
Biomolecular condensates comprise a diverse array of molecular entities, with intrinsically disordered regions (IDRs) receiving mounting attention due to their pivotal roles. In recent years, significant progress has been made in understanding the linear and conformational molecular grammar of IDRs…
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Jumping in the human brain: A review on somatic transposition
As a Nobel Prize-winning discovery, transposable elements, or “jumping genes”, have attracted significant interest due to their roles in providing functional coding and regulatory sequences. A longstanding hypothesis suggests that somatic transposition may preferentially occur in the mammalian…
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Self-powered decentralized water treatment clean boat with electrochemical fenton system for antibiotic remediation in natural water bodies
Decentralized solutions for the low-cost and sustainable treatment of large-scale natural water bodies contaminated with organic pollutants are urgently needed. This study introduces a self-powered clean boat using a photovoltaic (PV)-driven electrochemical Fenton system, featuring a gas diffusion…
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Molecule generation for drug design: A graph learning perspective
Machine learning, particularly graph learning, is gaining increasing recognition for its transformative impact across various fields. One such promising application is in the realm of molecule design and discovery, notably within the pharmaceutical industry. Our survey offers a comprehensive…
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Artikel Jurnal
Variations in glacier peak water timing and its influencing factors in High-Mountain Asia
High Mountain Asia (HMA) has the largest volume of glaciers outside the polar region and protects approximately 800 million people in the downstream basins against water stress. HMA is facing rapid glacier melting and substantial glacier mass loss, reaching the peak of runoff (‘peak water’) in the…
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Artikel Jurnal
Biological sequence analysis: Advances, medical applications, and challenges
With continuous developments in biotechnology and information technology, we are entering the era of biological sequence big data. Extracting valuable insights from large-scale data to decipher life activities presents a major challenge. Artificial intelligence, particularly big data analysis and…
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Enhancing cell subpopulation discovery in cancer by integrating single-cell transcriptome and expressed variants
The emergence of single-cell RNA sequencing (scRNA-seq) technology has revolutionized the study of cellular heterogeneity at the single-cell level. However, existing methods for identifying subpopulations of cells in scRNA-seq data mainly rely on gene expression features, neglecting the valuable…
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Artikel Jurnal
Response of rice production to rising CO2 and its adaptive cultivation strategies
Rice is the staple food for more than half of the population in China. Therefore, enhancing the grain yield of rice is the core of ensuring food security. In recent decades, the increase of atmospheric carbon dioxide (CO2) concentration generally increases the photosynthetic rate of rice and then…
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The evolving landscape of spatial proteomics technologies in the AI age
Although single-cell technologies have provided deep insights into cellular heterogeneity and complexity, they fall short in explaining how cells form tissue structures, a crucial aspect for understanding the principles of complex tissues. Recently, spatial transcriptomics has begun to fill this…
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Electrides: Emerging electronic materials for catalysis
Electrides are emerging materials that exhibit a unique electronic structure, where electrons, unbound to specific atomic nuclei, act as anions within periodic lattice vacancies. The most characteristic feature of an electride is its low work function (ΦWF < ∼3.5 eV), comparable to alkali metals…
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Artikel Jurnal
Exploring the economically sustainable solutions for clean heating in rural Northern China
China's Rural Clean Heating Policy (RCHP) is confronted with affordability issues in terms of the increasing household heating costs against the background of subsidies phase out, calling for economically feasible strategies to alleviate the heating burden. By compiling a high-resolution…
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Artikel Jurnal
Expanding bioinformatics: Toward a paradigm shift from data to theory
Bioinformatics is an interdisciplinary, fast-developing, and broad-ranging field, coevolving with and empowered by advanced technologies across multiple related disciplines. Given the ever-growing volume of biological data generated at multiple levels and scales, bioinformatics represents a…
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