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Advances in Cancer Biology - Metastasis
Scopus
ISSN 2667-3940 · Elsevier · 167 articles in the index
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Journal Article
Mathematical modeling of breast cancer: Analyzing immune-chemotherapy interactions and sensitivity to key parameters
In this study, we develop a biologically informed mathematical model of breast cancer that integrates key tumor, cytokine, and immune-cell interactions. To balance mechanistic detail with computational efficiency, a stepwise modeling strategy is adopted. In the first phase, the dynamics of two…
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Journal Article
Exploring the mechanism of Jianpi Guchang recipe and its compound: Inhibition liver metastasis in colorectal carcinoma through regulation of the bile acid-FXR-FGF19 axis
Objective: To explore the main mechanism by which Jianpi Guchang recipe (JPGC) prevents liver metastasis in patients with intestinal cancer and explain the related microbiological changes that regulate bile acid metabolism. Methods: To explore the effects of JPGC and its Compound on various…
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Journal Article
Integrative transcriptomic analysis of WNT/TGFβ-driven EMT pathways and drug-gene interaction networks in epithelial ovarian cancer
Background: Epithelial ovarian cancer (EOC) remains a lethal malignancy, and epithelial-mesenchymal transition (EMT) is a key driver of invasion, metastasis, and treatment resistance. Robust EMT-centered biomarkers in EOC are still lacking. We aimed to identify consensus EMT-related mRNA-miRNA…
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Journal Article
Combining mitochondrial morphology and cellular metabolism measurements improves colorectal cancer cell classification
Background: In many diseases, including cancer, the number, distribution and shape of mitochondria are affected. Under stress conditions and in tumor cells, changes in cellular, nuclear and mitochondrial morphology are frequently observed. Mitochondria are responsible for energy production and…
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Journal Article
Alcohol-induced extracellular vesicle signatures: Exploring liquid biopsy biomarkers for early cancer detection and prognosis
Alcohol intake is a significant causative factor of cancer, affecting liver, colorectal, oral/esophageal, and breast cancers. The toxicity of alcohol is due to the breakdown of acetaldehyde that damages DNA, interferes with metabolism, and generates oxidative stress. Such alterations undermine the…
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Journal Article
Decoding YAP's role in oral cancer metastasis: A systematic synthesis of experimental and clinical evidence
Background: Yes-associated protein (YAP), the key effector of Hippo signaling, is implicated in oncogenesis and metastasis in oral squamous cell carcinoma (OSCC). Prior reports vary in assay, model, and outcome definitions, limiting clear clinical translation. Methods: Following PRISMA 2020, we…
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Journal Article
Heat stress therapies for head and neck squamous cell carcinoma: Bibliometrics retrospective view
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer globally, with a 5-year survival rate of approximately 46 %. Although surgery, radiotherapy, and chemotherapy effectively treat HNSCC, they often cause severe side effects, including mucositis, salivary gland damage…
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Journal Article
miRNA-4722-3p targets GGT5 and inhibits gastric cancer cell progression via the PI3K/AKT-MAPK-MMPs signaling pathway
Gastric cancer (GC) is a common gastrointestinal malignancy, with more than one million new cases diagnosed each year. Identifying biomarkers for early diagnosis and prognosis is crucial to improving clinical outcomes. However, existing biomarkers lack sufficient sensitivity and specificity…
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Journal Article
The roles of cancer stem cell (CSC)-derived exosomal non-coding RNAs in cancer progression
Cancer stem cells (CSCs) are a small population of cancerous cells with aggressive phenotypes. Exosomes are small vesicles derived from cancer cells and CSCs containing non-coding RNAs, exhibiting tumor-promoting activity. Non-coding RNAs play a crucial role in tumor progression and metastasis…
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Journal Article
Targeting epithelial-to-mesenchymal transition of cancer cells by sulfated glycans from marine algae
Epithelial-mesenchymal transition (EMT) represents a process whereby an epithelial cell undergoes a series of alterations, acquiring the morphological and functional characteristics of a mesenchymal cell. EMT plays a significant role in the progression of cancerous cells, including metastasis…
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Journal Article
microRNA 146a suppresses tumor progression and enhances therapeutic sensitivity by targeting the EGFR pathway in BRCA1-associated basal-like breast cancers
BRCA1-associated basal-like breast cancers (BLBCs) are high-grade ductal carcinomas that frequently overexpress epidermal growth factor receptor (EGFR). EGFR overexpression is associated with tumor progression and metastasis, resistance to radiation and chemotherapy, and poor prognosis. Though EGFR…
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Journal Article
Anti-breast cancer effects of free and nanocarrier-loaded salinomycin and doxorubicin
Introductio: n: Salinomycin (SAL) and doxorubicin (DOX) have previously garnered much attention as anticancer drugs. However, their encapsulation within a nanocarrier dendrosome and their possible synergistic effect have not been reported, which we aim to address. Methods: SAL and DOX were loaded…
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Journal Article
Histone demethylase KDM6B inhibitor GSK-J4 sensitizes glioma cells to tyrosine kinase inhibitor anlotinib in vitro by reducing PDGFRA expression
Purpose: This study investigated the pharmacological effects and potential mechanisms of the tyrosine kinase inhibitor anlotinib and the histone lysine demethylase 6 B (KDM6B) inhibitor GSK-J4 on glioma cells. Methods: Brain pathological samples were analyzed with immunohistochemistry. The glioma…
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Journal Article
Repurposing statins in combination therapy for effective ablation of metastatic breast cancer
Metastatic breast cancer (mBC) remains an incurable disease with limited treatment options, highlighting the need for novel therapeutic approaches. The eventual development of resistance to commonly used regimens leading to relapse suggested the presence of intrinsically resistant heterogeneous…
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Journal Article
Anticancer efficacy of 2-Hydroxy-4-methoxybenzoic acid through dual regulation of lactate transport via inhibition of MCT-1 and MCT-4
Monocarboxylate transporters (MCTs) play critical role in the progression of mammary gland carcinoma. The unregulated cell growth increased glycolytic phenotype via glycolysis pathway which leads to concomitant synthesis of lactate. Lactate facilitates acidification of tumour microenvironment…
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Journal Article
Plasma proteomics reveals stage-specific EMT-linked signals: NAMPT in early and complement in advanced colorectal cancerSignificance Statement
Epithelial–mesenchymal transition (EMT) plays a dual role in driving both metastatic progression and therapy resistance in colorectal cancer (CRC). To identify systemic EMT-related signals across disease stages, we performed stage-specific plasma proteomics in treatment-naïve CRC patients from an…
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Journal Article
Natural bioactives in the suppression of EMT: A Focus on female cancer therapeutics
Cancer progression and mortality are predominantly caused by tumour invasion, metastatic dispersion, and the evolution of therapeutic resistance. Among the complex molecular mechanisms that contribute to these processes, epithelial-mesenchymal transition has emerged as a critical regulator of…
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Journal Article
LINC01106 promotes gastric cancer cell proliferation and migration through interactions with miR-34a-5p and FOXP1
LINC01106 is an oncogenic lncRNA that has been implicated in cancer progression through microRNA-related mechanisms, but its functional role and downstream effectors in gastric cancer (GC) remain incompletely characterized. This study examined whether LINC01106 affects GC cell proliferation and…
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Journal Article
LPIN1 exerts tumor-suppressive functions in HNSCC through autophagy-mediated inhibition of proliferation and metastasis
Recent studies highlight the magnesium-dependent phosphatidate phosphatase LPIN1 as a key regulator of tumor progression; however, its specific role and molecular mechanisms in head and neck tumors (including nasopharyngeal carcinoma and conventional head and neck squamous cell carcinoma, HNSCC)…
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Journal Article
Complexity of matriglycan and dystroglycan expression in cancers of epithelium origin
O-mannosylation of alpha-dystroglycan (α-DG) results in a glycan chain terminated with repeats of xylose and glucuronic acid biglycan termed as matriglycan linking the membrane DG to extracellular proteins. Lack of α-DG, particularly matriglycan in muscle and central nervous system, causes muscular…