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Frontiers in Toxicology
Scopus
ISSN 2673-3080 · Frontiers Media S.A. · 788 artikel di indeks
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Artikel Jurnal
A case report of arsenic-induced peripheral neuropathy misdiagnosed as Guillain-Barré syndrome
ObjectiveTo explore the clinical characteristics and misdiagnosis causes of arsenic-induced peripheral neuropathy.MethodsWe report a case of arsenic-induced peripheral neuropathy initially misdiagnosed as Guillain-Barré syndrome, with analysis of clinical characteristics, diagnostic workup and…
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Artikel Jurnal
Microplastic toxicity: mechanisms, assessment methods, and future research directions
Microplastics (MPs), plastic particles under 5 mm in diameter, represent a pervasive and persistent global environmental contaminant with cascading adverse effects on aquatic/terrestrial organisms and human health. While existing reviews have summarized isolated aspects of MP toxicity or assessment…
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Artikel Jurnal
Clinical features of toxic encephalopathy induced by 1,2-dichloroethane
Introduction1,2-Dichloroethane (1,2-DCE) is a highly toxic industrial organic solvent that can cause acute toxic encephalopathy through occupational exposure, with underreported clinical data in English literature. To explore the clinical characteristics and patients’ response to supportive…
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Addressing animal methods bias through government-led initiatives
Peer review aims to ensure that high-quality research is funded, conducted, and disseminated. However, peer review bias limits this process by violating impartiality, allowing factors other than merit to influence reviewers’ judgment. Animal methods bias is a peer review bias characterized by a…
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Foreign body reaction: towards a macrophage-centered adverse outcome pathway for fibrotic encapsulation
The foreign body reaction (FBR), characterized by chronic inflammation and fibrotic capsule formation around implanted medical devices, remains a major cause in device-related complications. Current preclinical risk assessment relies on in vivo testing according to ISO 10993-6:2024, which are…
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Artikel Jurnal
Multi-task deep learning models for mechanism-based prediction of developmental and reproductive toxicity (DART) using ToxCast bioassays
Developmental and reproductive toxicity (DART) testing has traditionally relied on animal studies, which are costly, time-consuming, and ethically constrained. To advance new approach methodologies (NAMs), we developed a mechanism-informed deep learning framework for predicting DART using in vitro…
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Perspectives on variability of in vivo toxicology studies: considerations for next-generation toxicology
IntroductionAnimal studies have historically informed toxicological testing and safety assessments. However, assessment of the variability in both quantitative and qualitative results has been limited. Biological variability, experimental differences, interpretation of categorical endpoints, and…
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Integrated microbiome-metabolome analysis reveals multiorgan toxicity of 1-nitropyrene and the limited efficacy of ferroptosis inhibitor Fer-1 in rats
Introduction1-Nitropyrene (1-NP), a prevalent nitro-polycyclic aromatic hydrocarbon, is increasingly recognized as a potential metabolic disruptor, yet its systemic biological effects remain insufficiently characterized.MethodsThis study investigated the metabolic, immunological, hepatic, and…
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“Algal-dromes”: a novel conceptual approach to illness in humans exposed to harmful algal bloom toxins
Although adverse health effects from harmful algal bloom (HAB) toxins have been described since antiquity, the true worldwide incidence and disease burden has yet to be defined. This is in part due to lack of reporting and under-recognition of exposure. Furthermore, when human exposure does occur…
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AI-enhanced clinical trial-in-a-dish platform for improved DILI risk classification and mechanistic insights into hepatotoxicity
Drug-induced liver injury (DILI) remains a leading cause of clinical trial attrition and post-marketing drug withdrawals. Its prediction is hindered by the limited physiological relevance and interindividual variability captured in conventional preclinical models. To overcome this, we developed a…
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Evaluating the QEAS-7 questionnaire as a predictor of asbestos burden in lung tissue among lung cancer patients: insights from the AMCANES study
ObjectivesAsbestos exposure is a known risk factor for lung cancer, and quantifying asbestos bodies (ABs) in lung tissue remains the gold standard for assessing cumulative exposure. However, histological analysis is not routinely available in many clinical settings. The validated QEAS-7…
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Review of the effect of atrazine on the HPG axes and steroidogenic pathways in males: relevance for testicular and prostate cancer
Subacute, subchronic, and chronic rodent studies on atrazine were evaluated to determine the no observed adverse effect levels (NOAEL) for male reproductive toxicity and carcinogenicity. In vitro studies were also evaluated for the effect of atrazine on molecular pathways related to male…
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Artikel Jurnal
Deciphering the toxicological mechanism of airway allergic diseases caused by dioctyl terephthalate: a composite study
BackgroundDioctyl terephthalate (DOTP), a common plasticizer alternative, has unclear immunotoxic effects on respiratory allergic diseases such as allergic rhinitis (AR), asthma (AS), chronic rhinosinusitis (CRS), and allergic bronchopulmonary aspergillosis (ABPA).MethodsWe integrated network…
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Berry e-liquid flavour toxicities are not equal on an alveolar-capillary barrier cell model according to two exposure methods
E-cigarettes are often presented as a smoking cessation tool, less harmful than tobacco and are now a regular feature of everyday life. However, the fruity and sweet flavours are attractive to teenagers who can use them recreationnaly. The main risk of this phenomenon is becoming trapped in…
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Exploring ethical, sustainable and effective foetal bovine serum alternatives for in vitro mammalian cell culture
Foetal bovine serum (FBS) has been widely used as a nutrient-rich supplement in mammalian cell culture for over 6 decades; however, its usage has increasingly raised various concerns and challenges related to quality variations, unethical collection practices, supply-demand imbalance and regulatory…
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From prioritization to implementation: updating the PARC WP5 project portfolio through the second prioritization round
The Partnership for the Assessment of Risks from Chemicals (PARC) represents a joint effort among risk assessors, regulatory authorities, and the scientific community to advance the implementation of next-generation risk assessment (NGRA) in line with the objectives of the EU Chemicals Strategy for…
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Artikel Jurnal
Microplastics amplify the pro-inflammatory response to fungal mycelial fragments and spores in neutrophil-like cells
BackgroundMicroplastic pollution has emerged as a global environmental crisis with potential adverse consequences on human health. Mixtures of microplastics with fungal particles including mycelial fragments or spores are highly probable exposure scenarios occurring in various occupational settings…
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From prediction to adaptation: rethinking the epistemic role of inhalation toxicology
Inhalation toxicology has long aimed to predict the health effects of airborne substances before exposure occurs, relying on stable dose-response relationships and well-characterized hazards. This approach becomes increasingly limited when confronted with emerging materials, complex mixtures, and…
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Appearance-based computer vision pipeline for multi-animal monitoring of canine activity, behavior and clinical observations
Behavioral monitoring of laboratory animals is essential for evaluating drug safety, yet existing assessments are typically limited to in-room observations by technicians. Here, we introduce our versatile AI model pipeline, composed of interconnected artificial neural networks that leverage…
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Artikel Jurnal
Effect of the cysteine prodrug L-2-oxothiazolidine-4-carboxylic acid on in vivo platelet activation, oxidative stress, and procoagulant responses induced by waterpipe smoke exposure in mice
IntroductionExposure to waterpipe smoke (WPS) in humans and experimental animals has been reported to cause oxidative stress and thrombotic complications. L-2-Oxothiazolidine-4-carboxylic acid (OTC) is a cysteine prodrug that maintains glutathione (GSH) in tissues. Nevertheless, the possible…