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Hearts
ISSN 2673-3846 · MDPI AG · 184 articles in the index
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Adherence Trajectories to Hypertension Treatment Among Older Individuals: Association with Depression and Anxiety?
Background: Effective hypertension management depends partly on medication adherence. Mental health disorders, such as anxiety and depression, may influence adherence, but evidence in older populations is limited. This secondary analysis of a cohort study identifies adherence trajectories to…
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Radiomics of Pericoronary Adipose Tissue on Coronary CT Angiography to Predict Clinical Outcomes: A Systematic Review
Background: Pericoronary adipose tissue (PCAT) radiomics on coronary computed tomography angiography (CCTA) may capture inflammatory and structural information beyond conventional attenuation measures. We assessed whether PCAT radiomics predicts future coronary events or quantifies plaque…
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Clinical and Epidemiological Profile of Children Evaluated at a Public Pediatric Cardiology Service in Southern Brazil
Background/Objectives: Congenital heart disease (CHD) is a major cause of congenital morbidity and mortality, but evidence from public pediatric cardiology services in Brazil remains limited. This study aimed to characterize the clinical and epidemiological profile of children and adolescents…
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Obesity Is Associated with Higher Odds of In-Hospital Mortality but Lower Risk of 5-Year Mortality in ST-Segment Elevation Myocardial Infarction Patients
Background: The ‘obesity paradox’, whereby obese patients demonstrate better clinical outcomes compared to normal-weight patients, has been reported in acute myocardial infarction, including ST-segment elevation myocardial infarction (STEMI). However, potential sex differences in this association…
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Semaglutide and the Heart: Focus on Their Love–Hate Relationship
Semaglutide, a recombinant DNA-derived long-acting GLP-1 receptor agonist, has emerged as a key player for patients with or without T2DM and obesity. It exerts pleiotropic effects by modulating glycemic regulation and energy homeostasis. Mechanistically, it stimulates glucose-dependent insulin…
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Cinematic Rendering as an Adjunct in Coronary CT Angiography: A Case Series on Myocardial Bridging and Intracameral-Appearing Coronary Courses
Background/Objectives: Myocardial bridging is a common anatomic variant in which an epicardial coronary artery takes an intramyocardial course. A true intracameral, or intracavitary, coronary course is rare. On coronary CT angiography (CTA), multiplanar and curved planar reformations answer most of…
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Metabolically Healthy Obesity Versus Metabolic Obesity on Long-Term Major Adverse Cardiovascular Events and Mortality in Women with Suspected Ischemic Heart Disease
Background: Obesity and metabolic syndrome (MS) often co-exist; however, these conditions can exist independently as metabolically healthy obesity (MHO) and as metabolic obesity (MO). Methods: We investigated the association between metabolic status and body weight and risk of obstructive…
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The Effect of Physical Activity on Heart Structure and Function in African University Students: A Comparative Cross-Sectional Study
Background: Regular physical activity induces physiological cardiac remodeling (“athlete’s heart”), which may overlap with pathological hypertrophy. Regional echocardiographic and electrocardiographic data among young African adults are limited. This study evaluated how graded physical activity…
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Unhealthy Alcohol Use and Sudden Death Among Working-Age Adults
Background: Unhealthy alcohol use may lead to arrhythmia and cardiomyopathy, but its impact on sudden death is not well understood. Objective: To investigate the association of unhealthy alcohol use with sudden death. Methods: We conducted a case-control study in Wake County, a large (~1 million…
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The Microvascular–Immune Interface in Cardiovascular Disease: A Stage-Based Framework of Microvascular Failure
Cardiovascular disease is traditionally interpreted through macrocirculatory parameters such as cardiac output, vascular resistance, and epicardial coronary anatomy. However, clinical outcomes frequently diverge from predictions based solely on these indices, particularly in syndromes such as heart…
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Size Your Valve: Sutureless Valve Size Recomendation System Using Machine Learning Algorithm
Background: Traditional intraoperative sizing for sutureless aortic valves, such as the Corcym Perceval Plus (CPP), often relies on subjective tactile feedback, which can lead to excessive over-sizing. Significant over-sizing is associated with complications like increased trans-prosthetic…
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Intraoperative Methadone in Adult and Pediatric Cardiac Surgery: A Narrative Review
Background/Objectives: Intraoperative methadone has emerged as a significant pharmacological strategy in cardiac surgery to improve postoperative analgesic outcomes and reduce the reliance on rescue short-action opioids. This review aims to synthesize evidence regarding the safety and efficacy of…
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NT-proBNP Discriminates Severe Systolic Dysfunction and Is Associated with Mortality in Advanced Duchenne Muscular Dystrophy: A Retrospective Cohort Study
Background: Cardiomyopathy is a major cause of morbidity and mortality in Duchenne muscular dystrophy (DMD). We evaluated whether N-terminal pro–brain natriuretic peptide (NT-proBNP) identifies severe systolic dysfunction and assessed its diagnostic performance. Methods: Male patients with…
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Paradoxical Coronary Artery Embolism Through a Patent Foramen Ovale in a Young Adult
We describe the case of a 26-year-old man who presented with acute chest pain and was found to have single-vessel coronary occlusion most consistent with probable paradoxical embolism. Coronary angiography demonstrated complete occlusion of the ramus intermedius artery. Aspiration thrombectomy…
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Correction: Kwak et al. The Influence of Body Mass Index on Percutaneous Coronary Intervention Outcomes: A National Inpatient Sample Study. Hearts 2025, 6, 5
There was an error in the original publication [...]
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Twiddler’s Syndrome: Predictors, Prevention, and Outcomes in a Case Series
Background/Objectives: Twiddler’s syndrome is an uncommon but clinically important complication of implantable cardiac devices, in which generator rotation within the pocket results in lead torsion, lead retraction, and device malfunction. Recurrence can necessitate repeated surgical intervention…
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Successful Pregnancy in a Woman with a History of Löffler’s Endomyocarditis and Recurrent Ventricular Thrombosis: A Case Report and Literature Review
We present the case of a 27-year-old woman diagnosed with Löffler’s endomyocarditis complicated by intraventricular thrombus and cerebral infarction. She was treated with prednisolone and anticoagulation therapy; however, tapering of corticosteroids resulted in recurrence of intraventricular…
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Transcatheter Edge-to-Edge Repair for Mitral Regurgitation: Distinct Interventional Paradigms for Primary and Secondary MR
Background/Objectives: Transcatheter edge-to-edge repair (TEER) has become an established therapeutic option for selected patients with mitral regurgitation (MR). However, primary (degenerative) and secondary (functional) MR represent distinct disease entities, characterized by different…
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Primary Prevention of Atherosclerotic Cardiovascular Disease Fails in Young Individuals According to Recent Data in The Netherlands
Background: Atherosclerotic cardiovascular disease (ASCVD) is one of the most important causes of morbidity worldwide. Registries show an impressive decline in prevalent ASCVD morbidity over the last years. Whether this decline is due to the improvement in treatment options for ASCVD or whether we…
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Percutaneous Retrieval of an Embolized Catheter Fragment in Right Heart Chambers in Pinch-Off Syndrome and Subsequent Reimplantation: Nurse’s Role in Interventional Cardiology—A Case Report
“Pinch-Off Syndrome,” first described by Hinke, is a mechanical complication of totally implantable central venous catheters inserted via subclavian venous access. It occurs when the catheter is compressed between the clavicle and the first rib. Compression can cause transient catheter obstruction…