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Biophysica
Scopus
ISSN 2673-4125 · MDPI AG · 308 articles in the index
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Lipid Modulation of Ion Channel Function
Ion channels are fundamental membrane proteins that mediate selective ion flow across biological membranes and thereby govern excitability, signaling, and homeostasis in virtually all cell types. Although channel function is determined by intrinsic structural features, the surrounding lipid milieu…
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Autophagy–Proteasome Crosstalk in Neurodegenerative Diseases: Cellular Proteostasis, Neural Interactions, and Therapeutic Implications
Neurodegenerative conditions such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and amyotrophic lateral sclerosis (ALS) are devastating disorders with the gradual loss of neurons and cognitive or motor disability. This is a review article that develops the crucial functions of…
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Protein Folding and the Minimum Rate of Entropy Production
Protein folding displays a very narrow range of stability energy as measured by the ΔG° value associated with the process of protein folding from the unfolded sequence of amino acids defining a particular protein. We have recently reported the Gaussian distribution of ΔG° values obtained from a…
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Radiobiology-Guided VMAT Radiotherapy Optimization for Locally Advanced Cervical Cancer
This retrospective planning study evaluated how arc number (AN) and control-point density (CP) affect VMAT quality, radiobiological endpoints, and workflow efficiency for locally advanced cervical cancer in a resource-conscious setting. Twenty-one patients (FIGO IIB–IIIB) were replanned in Monaco…
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Mitochondrial Transport and Metabolic Integration: Revisiting the Role of Metabolite Trafficking in Cellular Bioenergetics
Mitochondria serve as central hubs of cellular metabolism, integrating catabolic and anabolic pathways through the controlled exchange of metabolites across their membranes. Although mitochondrial transport of several metabolites has been well documented, the mechanisms underlying the trafficking…
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Computational Analysis of Microalgal Proteins with Potential Thrombolytic Effects
Thrombosis is a cardiovascular disease characterized by the pathological formation of a fibrin clot in blood vessels. Currently available fibrinolytic enzymes have some limitations, including severe side effects, high cost, short half-life, and low fibrin specificity. Proteins from microalgae and…
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Anticancer Activity of a pH-Responsive Nanocomposite Based on Silver Nanoparticles and Pegylated Carboxymethyl Chitosan (AgNPs-CMC-PEG) in Breast (MCF 7) and Colon Cancer Cells (HCT 116)
Cancer is one of the leading causes of mortality worldwide, with breast and colon cancers being among the most common neoplasms in men and women, respectively. Despite significant advancements in treatment, there is a pressing need to enhance specificity and reduce systemic side effects…
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β Alanine Modulates the Activity and Stability of Peroxiredoxin 6: A Biochemical and Mechanistic Study
Peroxiredoxin 6 (Prdx6) is a bifunctional antioxidant enzyme with glutathione peroxidase and phospholipase A2 activities that plays an essential role in cellular redox regulation. However, the modulation of Prdx6 activity by endogenous small metabolites remains poorly understood. In this study, we…
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Extraction, Purification and Current Status of Biocompatibility Applications of Fish Collagen
Fish collagen is derived from processing residues of marine and freshwater fish (such as fish skin, scales, and bones), primarily composed of amino acids including glycine, proline, and hydroxyproline. It functions include maintaining tissue integrity and promoting cell proliferation and repair…
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Cell Biophysics–Physiological Contexts, from Organism to Cell, In Vivo to In Silico Models: One Collaboratory’s Perspective
Here we present a retrospective, integrative review of the approaches and discoveries of our “collaboratory”, a meta-laboratory comprising cross-disciplinary collaborations across laboratories at fourteen different universities and clinics in seven different countries with shared lead…
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Comparison of Structure and Dynamics of ORF8 Binding with Different Protein Partners Through Simulation Studies
ORF8 is the second most mutated protein in SARS-CoV-2. It can form oligomers such as trimers and can bind to the IL-17RA/RC receptor. To understand the possible role of ORF8 in SARS-CoV-2, the first step of this study involved predicting the ORF8 trimer structure and the complex structure of the…
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Molecular Survival Strategies Against Kidney Filtration: Implications for Therapeutic Protein Engineering
The glomerular filtration barrier poses a significant challenge for circulating proteins, with molecules below ~60–70 kDa facing rapid renal clearance. Endogenous proteins have evolved sophisticated evasion mechanisms including oligomerization, carrier binding, electrostatic repulsion, and…
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Comparative Experimental and Viscoelastic Modeling Study of Human Tibial Trabecular Bone Under Healthy and Osteoarthritic Conditions
Background: The development of osteoarthritis (OA), a whole-joint disorder that is increasingly recognized, depends on subchondral trabecular bone. Variations in the viscoelastic characteristics of trabecular bone have been proposed to affect load distribution and potentially lead to joint…
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The Characterization of AAV Capsid Individual VP-Specific Charge Heterogeneity Using a High-Throughput Reduced Denatured iCIEF–Western Method
In recent years, advancements in gene therapy have highlighted the important role of adeno-associated viruses (AAVs) due to their favorable characteristics, such as low immunogenicity compared to other viral vectors, e.g., lentivirus and HSV, and the ability to maintain gene expression in a variety…
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Mesenchymal Stem Cells as a Regenerative Treatment for Musculoskeletal Pain
Mesenchymal stem cells (MSCs) have become a focus of regenerative medicine research due to their potential utility in treating a variety of musculoskeletal disorders. Multiple qualities make them an ideal candidate to address musculoskeletal structural degeneration and inflammation, including their…
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Computational Study of Terpenes from Schinus molle L. Fruit Essential Oil as Potential Modulators of Osteoarthritis-Related Inflammatory Pathways: A Network Pharmacology and Molecular Docking Study
This study investigated the effects of terpene compounds from Schinus molle fruit essential oil (EO) against osteoarthritis (OA) using integrated network pharmacology, molecular docking, and molecular dynamics. The EO, obtained by steam distillation (yield: 6.95%), was characterized by GC-MS…
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Comparative Docking Suggests Peripheral Association of Tirapazamine with Bovine Serum Albumin
Molecular docking was used to investigate the interactions between tirapazamine (a bioreductive anticancer drug) and bovine serum albumin (BSA), with emphasis on binding site localization and geometry. Docking simulations were performed using SwissDock with the AutoDock Vina 1.2.0 scoring engine…
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Amber Suppressor tRNA-Based Mutagenesis for Positional Semi-Saturated Mutagenesis with Natural Amino Acid Substitutions: An Approach for Mapping Positional Contributions to Protein Function
There is a growing interest in methods that illuminate the contributions of individual positions to a protein’s function by site-saturating mutagenesis. However, a commonly used approach for assessing variant libraries with deep mutational scanning relies on readouts of biological fitness, which is…
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Body Distribution and Occupational Dispersion of Scandium-47 Chloride: Safety Considerations for Radiopharmaceutical Development
This study investigated the distribution and dispersion of Sc-47 (47Sc), a β-emitting radionuclide that can be produced in large quantities using accelerators. As the stability of labeled compounds inside the body is essential for nuclear medicine therapy, we examined the biodistribution of free…
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A Biophysical and ALARA-Based Comparison of 3D-CRT and IMRT for Spinal Cord Compression
Metastatic spinal cord compression (MSCC) requires urgent radiotherapy. However, selecting the optimal technique that balances dosimetric precision with treatment efficiency remains clinically challenging. This study compares four radiotherapy modalities for MSCC—AP-PA with field-in-field, 3D-CRT…