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Livers
Scopus
ISSN 2673-4389 · MDPI AG · 293 artikel di indeks
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Artikel Jurnal Teks lengkap
Pyroptosis- and Cuproptosis-Targeting Natural Compounds as a Promising Approach for Hepatocellular Cancer Treatment
Background/Objectives: Hepatocellular carcinoma (HCC) is the most common primary liver cancer worldwide, posing significant health challenges due to its high morbidity and mortality rates. Emerging evidence indicates that non-apoptotic cell death mechanisms, including pyroptosis and cuproptosis…
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Intestinal Microbiota and Hepatitis C: Dysbiosis During the Natural History of the Disease and Treatment
It is known that the composition of the intestinal microbiota (IM) is associated with the pathogenesis of viral hepatitis. Hepatitis C virus (HCV) is an RNA virus that affects about 50 million people worldwide. HCV infection is considered a major risk factor for developing liver cirrhosis and…
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A Multivariable Model for Predicting Intraoperative Blood Loss in Pediatric Liver Transplantation
Background/Objectives: Intraoperative bleeding remains one of the major challenges in pediatric liver transplantation (PLT), contributing significantly to perioperative morbidity, transfusion-related complications, and prolonged recovery. Although viscoelastic testing has improved intraoperative…
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Identification of Unrecognized Hepatitis B, C, and D Infections Through the Private Laboratory-Based RE-LINK Screening Project in Romania: A Micro-Elimination Initiative
Background/Objectives: Chronic hepatitis B (HBV) and C (HCV) remain major public health challenges in Romania despite vaccination and antiviral therapy. Understanding infection patterns in different healthcare settings is essential for targeted elimination strategies. Methods: We conducted the…
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Metabolic Dysfunction-Associated Steatotic Liver Disease in People Living with HIV: A Scoping Review
Metabolic dysfunction-associated steatotic liver disease (MASLD), previously called non-alcoholic fatty liver disease (NAFLD), has become a leading cause of chronic liver disease in people living with HIV (PLWH), especially in the era of effective antiretroviral therapy (ART). As the life…
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Epidemiology and Clinical Outcomes in the 20-Year HepCoVe Cohort: Progress Toward Elimination of HCV Infection in North-East Italy
Background and Objectives: The increase in rates of cirrhosis and hepatocellular carcinoma (HCC) due to HCV infection supported the implementation of screening programs for control of this infection in Italy. The HepCoVe network has collected cases with chronic hepatitis C (CHC) in the Veneto…
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Indeterminate-Grey Zone of HBeAg-Negative Chronic Hepatitis B Is Associated with a Higher Risk of Hepatocellular Carcinoma Compared to HBeAg-Negative Chronic Infection—A Systematic Review and Meta-Analysis
Background and Aim: The management of patients with chronic Hepatitis B Virus (HBV) HBeAg-negative infection in the indeterminate-grey zone (GZ) remains debatable. We conducted a systematic review and meta-analysis to compare these patients with those with chronic HBV HBeAg-negative infection…
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Effect of Submaximal-Dose Semaglutide on MASLD Biopsy-Free Scoring Systems in Patients with Obesity
Introduction: The prevalence of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) is rapidly increasing, possibly becoming the leading cause of chronic liver disease (CLD) in the coming years. Samaglutide (a long-acting glucagon-like peptide receptor agonist 1—GLP-1RA) therapy might…
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The Liver at the Crossroads: Orchestrating Lipoprotein Dynamics and Lipid Homeostasis
The liver plays a central role in numerous physiological processes, with one of its most critical functions being the regulation of lipid homeostasis through both the biogenesis and secretion of very low-density lipoproteins (VLDLs) and fatty acid oxidation. By forming and secreting VLDLs, the…
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Gut Microbiota-Mediated Molecular Events in Hepatocellular Carcinoma: From Pathogenesis to Treatment
Background/Objectives: Hepatocellular carcinoma (HCC) is one of the most common causes of cancer and cancer-related death worldwide. Beyond the well-known factors influencing the risk of HCC, experimental data from animal models and observational human studies support a significant role of the gut…
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Early-Stage Australian HCC Patients Treated at Tertiary Centres Show Comparable Survival Across Metropolitan and Non-Metropolitan Residency
Background: Hepatocellular carcinoma (HCC) poses a significant public health challenge in Australia, with poorer survival observed in non-metropolitan populations. This study investigated whether survival disparities persist between non-metropolitan and metropolitan patients if only those with…
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Completeness of Initial Laboratory Evaluation Impacts Chronic Hepatitis B Outcomes
Introduction: The health care burden of chronic hepatitis B virus (CHB) infection can be reduced by appropriate workup, treatment, and monitoring. Methods: As a primary objective, we determined whether adequate initial hepatitis B virus (HBV) laboratory workup in CHB patients is associated with…
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Bridging the Bench-to-Bedside Gap with Multimodal Artificial Intelligence in Digestive Diseases
This comment discusses a recent review by Wu and colleagues on multimodal artificial intelligence in gastroenterology and hepatology. The review outlined advancements in endoscopic, radiomics, pathologic, and multi-omics technologies. Additionally, it highlights persistent barriers, such as data…
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Prevalence of Liver Fibrosis and Cirrhosis in High-Risk and Hospital-Based Populations in Morocco: A Systematic Review and Narrative Synthesis
Background: Liver diseases are an increasing public health concern in Morocco; reliable national population-based estimates of liver fibrosis and cirrhosis in Morocco are currently unavailable. Existing evidence is largely limited to selected high-risk groups and hospital-based cohorts. Generating…
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Association Between Phase Angle as an Indicator of Sarcopenia and Steatotic Liver Disease in the General Population
Background: Steatotic liver disease (SLD) and sarcopenia are lifestyle-related conditions for which prevention is critical. The phase angle, which is derived from impedance, reactance, and resistance values obtained via bioelectrical impedance analysis, has emerged as a potential marker of…
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A New Ultrasound Method to Study the Relations Between Ileocecal Valve Incontinence and Inflammation in Metabolic Associated Steatotic Liver Disease
Background: Small intestine bacterial overgrowth (SIBO) is associated with steatohepatitis (SH) in subjects with metabolic-associated steatotic liver disease (MASLD). The impact of ileocecal valve (ICV) incontinence, a major cause of SIBO in patients with MASLD, remains unknown because of the unmet…
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Integrative Profiling of Metabolic CYP Expression, DNA Mutation Rates, and Immune Cell Infiltration for Survival Prognosis in Hepatocellular Carcinoma
Background/Objectives: Hepatocellular carcinoma (HCC) is challenging to treat with chemotherapy. Immunotherapy has shown moderate responses in inflammatory and immunosuppressive tumor environments. Hepatic cytochrome P450 monooxygenases (CYPs) play a crucial role in xenobiotic and drug metabolism…
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Limited Agreement of Different Elastography Techniques in Assessing Liver Stiffness in Postmenopausal Women with Early-Stage Metabolic Dysfunction-Associated Steatotic Liver Disease
Background/Objectives: Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease. Accurate staging of hepatic fibrosis is pivotal for risk stratification; however, ultrasonography (US)-based elastography techniques may yield variable results across…
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Artikel Jurnal Teks lengkap
Human-Mouse Convergence in Metabolic Dysfunction-Associated Steatotic Liver Disease: Mouse Model Selection and Non-Invasive Diagnostic Strategies
Background: Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) is a global health priority affecting approximately 30% of the population. It represents the hepatic manifestation of metabolic syndrome, potentially progressing from simple steatosis to Metabolic Dysfunction-Associated…
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Artikel Jurnal Teks lengkap
Surgical Decision-Making and Clinical Characteristics in Porcelain Gallbladder: A Systematic Review of Case Reports
Porcelain gallbladder (PGB) has historically been considered a premalignant condition, although recent evidence questions the strength of its association with gallbladder carcinoma. Objective: To describe the occurrence and characteristics of malignancy in patients with porcelain gallbladder, as…