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Immuno
Scopus
ISSN 2673-5601 · MDPI AG · 262 artikel di indeks
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Artikel Jurnal Teks lengkap
Ibuprofen Modulates Tissue-Specific Proteomic Signatures of LPS-Induced Inflammaging in Mice
Chronic low-grade inflammation (“inflammaging”) is epidemiologically linked to organ-specific aging, but tissue-resolved proteomic evidence remains limited. In this exploratory study, we used 4D-DIA proteomics to profile heart, liver, spleen, and kidney from mice given chronic LPS (0.1 µg/day i.p…
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Sub-Lethal Cryoablation Promotes Systemic Antitumor Immunity
Although cryoablation of tumor tissue is known to induce systemic antitumor immune responses, the underlying mechanisms remain poorly understood, and therapeutic efficacy is often unpredictable. During cryoablation, the cryoprobe creates a temperature gradient, resulting in a central zone of lethal…
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Association of CSF2, IL12B, IL23R, TNF, IL6 and IL10 Gene Polymorphisms with Susceptibility to Takayasu Arteritis
Background: Takayasu arteritis (TA) is a large-vessel vasculitis with an incompletely understood pathogenesis, in which genetic factors are thought to play an important role. Cytokine-mediated immune pathways, particularly those involving Th1 and Th17 responses, have been implicated in the…
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Sequential Immune Dynamics in Chronic Nasopharyngeal Inflammation
Chronic nasopharyngeal inflammation represents a state of persistent mucosal immune dysregulation within the nasopharynx, a key inductive site of upper airway immunity. In this review, we propose a hypothesis-generating conceptual framework in which disease progression reflects a sequential shift…
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Frequency of Allergic Rhinitis Among Phenotypes of Chronic Rhinosinusitis in Patients Treated Surgically: An Experience from a University Hospital
Background/Objective: Previous studies on the association between chronic rhinosinusitis (CRS) and allergic rhinitis (AR) have mostly focused on the general population, and much less on patients with CRS requiring surgical treatment. This study aimed to investigate the frequency of perennial and…
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Cellular Senescence in Oral Lichen Planus: Evidence, Limitations, and Future Perspectives
Oral lichen planus (OLP) is a chronic T cell-mediated inflammatory disorder characterized by recurrent epithelial injury and incomplete inflammatory resolution. Cellular senescence and the senescence-associated secretory phenotype may help explain how stromal cells sustain this inflammatory…
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New Insights in Diagnosis and Therapy of Paroxysmal Nocturnal Hemoglobinuria (PNH)
PNH is an acquired ultrarare disease caused by a somatic mutation of PIGA gene located at band 22 of the short arm of the X chromosome, which is unable to carry out the synthesis of glycosil-phosphatidyl-inositol. The loss of complement regulators CD55 and CD59 is associated with the lack of the…
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Transcriptomic Analysis Identifies Putative Hematopoietic Co-Expression Networks in Icariin-Mediated Recovery from Cyclophosphamide-Induced Immunosuppression
Background: Cyclophosphamide (CTX)-induced immunosuppression involves systemic toxicity, splenic atrophy, and broad transcriptomic disruption. Icariin (ICA) has immunomodulatory activity, but the systems-level features associated with splenic recovery remain incompletely defined. Methods and…
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An Updated Individual-Patient-Data Systematic Review and Meta-Analysis of Reported DOCK8 Deficiency Cases (2017–2026): Genotype, Phenotype, Malignancy, Infection Spectrum, and Transplant Outcomes
Background: Dedicator of cytokinesis 8 (DOCK8) deficiency is an autosomal-recessive combined immunodeficiency marked by severe cutaneous viral infections, atopy with elevated IgE, malignancy, and early mortality without hematopoietic stem-cell transplantation (HSCT). Foundational syntheses predate…
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Role of m6A RNA Methylation in T Cell Biology and Immunotherapy
RNA modifications act as crucial post-transcriptional regulators that fine-tune gene expression to modulate cell function. Among these, N6-methyladenosine (m6A) is the most prevalent RNA modification in eukaryotic cells, regulating several RNA metabolism pathways including RNA splicing, nuclear…
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Baseline Endometrial Microbiome Composition Determines Response Following Intrauterine Peripheral Blood Mononuclear Cell (PBMC) Therapy in Assisted Reproduction Patients
The endometrial microbiome has been implicated in implantation success, and intrauterine peripheral blood mononuclear cell (PBMC) therapy has been proposed to improve endometrial receptivity; however, its effects on the endometrial microbial environment remain poorly understood. This prospective…
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From Metastatic Gateways to Immune Reservoirs: Reframing Tumor-Draining Lymph Nodes in Perioperative Cancer Immunotherapy
Immune checkpoint inhibitors (ICIs) are now being introduced into perioperative treatment for several solid tumors. This strategy is usually explained by tumor reduction before surgery or by the elimination of minimal residual disease (MRD) after surgery. However, these explanations may not be…
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Engineering an Innovative Chimeric Multi-Epitope RNA-Based Vaccine Against Neonatal Calf Diarrhea Pathogens (Bovine Coronavirus, Bovine Rotavirus, and Escherichia coli K99): An In Silico-Based Analysis
Neonatal calf diarrhea (NCD) is one of the most important problems of calf breeding across the world. It causes deaths in calves in the first 10 days of their life, and it is mainly caused by Escherichia coli(E. coli), Bovine Rotavirus (BRV) and Bovine Coronavirus (BCoV). The lack of vaccines with…
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Protein-Level and Proteomics-Supported Signatures of Human CD4+ Regulatory T Cells: Evidence, Tissue Context, and Translational Readiness in Aging and Age-Associated Disease
Regulatory CD4+ T cells (Tregs) are essential for immune tolerance, tissue repair, and control of inflammation, but functional human Tregs cannot be identified reliably by a single protein. This targeted narrative review evaluates protein-level and proteomics-supported Treg signatures with explicit…
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Immune-Mediated Coronary Stent Failure: From PCI-Induced Vascular Injury to In-Stent Restenosis, Neoatherosclerosis and Stent Thrombosis
Percutaneous coronary intervention (PCI) treats focal coronary obstruction by compressing plaque, injuring the vessel wall, and placing a metallic or bioresorbable scaffold. Most treated segments heal, but a small minority enter a prolonged, excessive, or unstable repair state that contributes to…
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Cytokine-Mediated Hemorheological Alterations in Chronic Chagas Disease
Chagas disease is a parasitic infection caused by Trypanosoma cruzi and remains an important public health problem with changing epidemiological patterns. Both the acute and chronic phases pose diagnostic and prognostic challenges due to the disease’s heterogeneous clinical course. Chronic…
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Post-Translational Circadian Regulation of Inflammation: Mechanistic Control of Immune Signaling Networks
Circadian rhythms impose temporal organization on immune function, shaping host responses to infection, injury, and chronic disease. While transcriptional control by core clock components such as CLOCK and BMAL1 has been extensively characterized, this paradigm alone cannot explain the rapid and…
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Immunomodulatory Potential of Agro-Industrial Residues: Passiflora edulis and Rubus glaucus Seed Oils Promote MMP-9 Release from Human Neutrophils
Background: Neutrophil dysregulation drives inflammatory pathologies through mechanisms such as matrix metalloproteinase-9 (MMP-9) release. High-value bioprospecting of agro-industrial residues offers a sustainable strategy to identify novel bioactive compounds. In this study, the immunomodulatory…
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Coordinated Th1- and Th17-Related Responses Support Antibody- and Neutrophil-Mediated Protection Against Pneumococcal Pneumonia
Streptococcus pneumoniae is a leading cause of community-acquired pneumonia, yet the immune mechanisms required for protection against invasive pulmonary infection remain inadequately understood. Using a murine model of homologous protection against invasive pneumococcal pneumonia, we explored the…
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CDK4/6 Inhibition and Stereotactic Radiotherapy in Oligometastatic HR+/HER2− Breast Cancer: Evidence of Immunogenic Modulation and Pseudoprogression
Background: A combination of cyclin-dependent kinase 4/6 inhibitors (CDKi) and radiotherapy (RT) may enhance antitumoral immunity, yet clinical evidence of this interaction in HR+/HER2− metastatic breast cancer (MBC) remains limited. This study evaluates the impact of combined CDKi and stereotactic…