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Frontiers in Allergy
Scopus
ISSN 2673-6101 · Frontiers Media S.A. · 972 artikel di indeks
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Artikel Jurnal
The AhR–TLR4 axis in non-IgE-mediated Cow's milk allergy: a systematic review with integrated multi-omics corroboration
Background & aimsNon-IgE-mediated cow's milk allergy (non-IgE-CMPA) is the most prevalent form of CMPA in infancy; however, its pathogenesis is still poorly understood, which impedes the development of targeted nutritional strategies. Recent evidence suggests a connection between gut dysbiosis and…
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Artikel Jurnal
The Spanish REAL project: expert allergist guidance on allergen immunotherapy based on mixtures from different allergenic sources
BackgroundThe increase in polyallergy highlights allergen-specific immunotherapy (AIT) as a crucial therapeutic option for these patients. It is the only etiological treatment capable of modifying the natural course of allergic diseases. Its use, particularly with mixtures from different allergenic…
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Artikel Jurnal
Impact of biologicals on revision ESS numbers in CRSwNP in a tertiary care rhinology center
BackgroundSince 2022, several biologics are indicated and reimbursed for Belgian patients with severe uncontrolled CRSwNP despite previous endoscopic sinus surgery (ESS). Data on the impact of biologics on the number of patients undergoing revision ESS are lacking.MethodsWe analyzed the trend in…
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Artikel Jurnal
A shared metabolic-immune axis links local and systemic inflammation in chronic rhinosinusitis with comorbid asthma
BackgroundChronic rhinosinusitis with nasal polyps (CRSwNP) comorbid with asthma (CRSwA) represents a severe “unified airway” phenotype, yet the metabolic mechanisms linking upper and lower airway inflammation remain unclear. This study aimed to identify shared metabolic signatures connecting local…
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Artikel Jurnal
Nasal eosinophilia and its clinical correlates in patients with allergic rhinitis at a Kenyan tertiary hospital
IntroductionAllergic Rhinitis (AR) is an IgE- mediated inflammatory disease of the nasal mucosa. While the diagnosis mainly relies on a typical clinical history and physical examination, the evaluation of eosinophils in nasal smears is considered a direct marker of inflammation and can play a role…
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Artikel Jurnal
Current challenges in allergic diseases and computational solutions towards personalized medicine
Allergic diseases persist as a significant global health concern, profoundly diminishing the quality of life for millions of people across the globe. Allergic diseases exert a growing economic toll worldwide, with prevalence rates rising sharply – now affecting between 10% and 30% of the global…
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Artikel Jurnal
Pentraxin 3 deficiency exacerbates neutrophilic inflammation and airway hyperresponsiveness in type 2-low asthma
BackgroundType 2-low asthma is a severe, steroid-resistant phenotype characterized by neutrophilic inflammation and limited treatment options. PTX3, an acute-phase protein involved in innate immunity, has been linked to inflammatory diseases; but its role in type 2-low asthma remains…
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Biologic therapies for severe pediatric asthma: efficacy, safety, and biomarker-guided selection
BackgroundSevere pediatric asthma is a heterogeneous, high-burden disease marked by variable corticosteroid responsiveness, frequent exacerbations, and substantial impairment in quality of life. Advances in airway immunobiology, particularly the delineation of type-2 (T2) pathways (IgE, IL-5…
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IgE, anti-IgE therapy, and regulatory T cells: new paradigms in allergic inflammation
Allergic inflammation arises from a dysregulated immune response in which immunoglobulin E (IgE) plays a central pathogenic role. By binding to its high-affinity FcεRI on mast cells and basophils, IgE orchestrates the rapid activation and mediator release that underlies immediate hypersensitivity…
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Safety of a novel oral immunotherapy approach in preschool children with single and multiple food allergies
BackgroundOral immunotherapy (OIT) has emerged as a promising food allergy treatment with significant evidence of increased efficacy in preschool-aged children. However, current OIT protocols are generally burdensome and focus on single food allergies, while many children have multiple food…
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Artikel Jurnal
Calcium-binding proteins as allergens
Calcium-binding proteins, particularly those in the EF-hand family, are found ubiquitously in nature, primarily for calcium transport and storage in the body. In this review, we discuss allergens in the parvalbumin, polcalcin, sarcoplasmic calcium-binding protein, and troponin C families, as well…
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The knowledge, attitudes and practice of nasal irrigation among patients with rhinosinusitis: a cross-sectional study
ObjectiveNasal inflammatory diseases significantly impair patients' quality of life, with global prevalence varying regionally. Nasal irrigation, endorsed by international guidelines as adjunctive therapy, lacks standardized protocols and patient education, potentially compromising efficacy. This…
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EGFR inhibitors suppress house dust mite allergen Der pII induced inflammation in monocytes and macrophages
IntroductionAllergic asthma, often triggered by house dust mites (HDMs), is characterized by airway inflammation, mucus hypersecretion, and airway hyperresponsiveness. Among the major HDM allergens, Der pII plays a significant role in promoting inflammation. This study investigates the role of…
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Artikel Jurnal
Comparison of rapid and same-day desensitization protocols in hypersensitivity reactions to platinum and taxanes: a retrospective cohort study
BackgroundRapid drug desensitization (RDD) allows first-line treatment to continue after a hypersensitivity reaction to the antineoplastic agent. There are different desensitization procedures, and none of them are free from breakthrough reactions (BTR).ObjectivesThe objective of the study is to…
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Artikel Jurnal
PPARγ: a key orchestrator of epidermal barrier, immune responses, and lipid metabolism in atopic dermatitis pathogenesis and therapy
Atopic dermatitis (AD) is an immune-mediated inflammatory dermatosis characterized by epidermal barrier dysfunction, immune dysregulation, and cutaneous microbial dysbiosis. Existing therapeutic modalities for AD are limited in efficacy and durability, highlighting an unmet clinical need for novel…
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EUFOREA summit in Brussels 2025: inspiring the future of allergy and respiratory care
EUFOREA, the European Forum for Research and Education in Allergy and Airways diseases, is an international non-for-profit organisation of physicians, patients, and other stakeholders committed to the improvement of outcomes for patients suffering from chronic inflammatory respiratory conditions…
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Artikel Jurnal
Depemokimab demonstrates efficacy in patients with type 2 asthma with comorbid CRSwNP: Phase III SWIFT-1/-2 analysis
IntroductionThe efficacy of twice-yearly depemokimab was demonstrated in the Phase III SWIFT-1/-2 trials for type 2 asthma characterized by blood eosinophils, and ANCHOR-1/-2 trials for chronic rhinosinusitis with nasal polyps (CRSwNP). Up to 40% of patients with severe asthma are estimated to have…
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Artikel Jurnal
Plasma glutathione peroxidase activity negatively correlates with atopic diseases in children but not adults: an exploratory study
Atopic diseases, including atopic dermatitis, food allergy, allergic rhinitis, asthma, and eosinophilic esophagitis (EoE), are characterized by chronic inflammatory responses to aero- and/or food allergens. Oxidative stress has been increasingly implicated in the pathogenesis of these conditions…
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Artikel Jurnal
Cross-IgE sensitization correlates with cross-anaphylaxis among peanut and multiple tree nuts in a murine model
BackgroundThe incidence of multiple food allergies (MFA), defined as exhibiting allergic responses to two or more distinct food groups, has been increasing. Since peanut (PN)/ tree nuts (TN) MFA causes severe reactions, it is challenging to study cross-reactivity immediately using human subjects…