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Frontiers in Aging
Scopus
ISSN 2673-6217 · Frontiers Media S.A. · 850 artikel di indeks
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Artikel Jurnal
Molecular pathways linking chronic psychological stress to accelerated aging: mechanisms and interventions
Chronic psychological stress refers to repeated or prolonged exposure to adverse social or emotional threats that exceed an individual’s adaptive capacity. It is recognized as a risk factor for aging-associated diseases. A growing body of research has shown that there is a link between chronic…
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Artikel Jurnal
Periorbital skin index as a biomarker for biological aging and health status
BackgroundThe periorbital skin area is particularly susceptible to aging compared to other facial regions due to its unique anatomical features and frequent muscle movements. This leads to early development of wrinkles and discoloration, which affect one’s appearance. Because of these…
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Artikel Jurnal
Data-driven frailty and reserve phenotypes in older outpatients: a cluster analysis of Comprehensive Geriatric Assessment
BackgroundThe progressive aging of the population represents a critical public health challenge. Within this context, the management of frailty has emerged as a central priority in geriatric care, with Comprehensive Geriatric Assessment (CGA) widely recognized as the gold-standard tool for its…
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Unwanted loneliness among older adults in rural areas: associated factors and guidelines for community intervention
BackgroundUnwanted loneliness among older adults has become a growing public health concern, particularly in rural contexts characterized by population aging, depopulation, and limited access to services. While many interventions focus on functional and social dimensions, the subjective and…
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Artikel Jurnal
Combined spinal cord stimulation and intrathecal Morphine–Sufentanil therapy for refractory cancer pain: a case report
This case report describes the management of a 61-year-old female patient with metastatic adenoid cystic carcinoma and chronic refractory cancer pain. Initially treated with spinal cord stimulation (SCS), she later developed tolerance and inadequate analgesia. An intrathecal drug delivery system…
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A comprehensive review of artificial intelligence as a catalyst in aging research: insights, gaps and future perspectives
Aging is driven by interconnected genetic, epigenetic, molecular, and physiological processes spanning from unicellular to organismal levels. The surge in high-throughput data, from clinical and imaging to multi-omics, has outpaced traditional analysis methods; driving the integration of artificial…
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Artikel Jurnal
Tensiomyography-derived contractile parameters in sarcopenic and non-sarcopenic older adults
BackgroundSarcopenia, the progressive decline in skeletal muscle mass and function, is a major public health concern linked to falls, hospitalization and loss of independence among older adults. Initially defined by reduced muscle mass, later also by reduced muscle strength and function, it is now…
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Artikel Jurnal
Intravenous infusion of nicotinamide adenine dinucleotide (NAD+) versus nicotinamide riboside (NR): a retrospective tolerability pilot study in a real-world setting
BackgroundNicotinamide adenine dinucleotide (NAD+) is a cofactor for NAD+-dependent enzymes that regulate DNA repair, cellular metabolism, and immune function. Supplementation with NAD+ and its precursors is commonly used to prevent age-related disease and extend healthspan. Commercial clinical and…
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Phenotypic and functional heterogeneity of naïve CD8+ T cells in human peripheral blood during aging
Naïve CD8+ T cells are key players of adaptive immunity, but their heterogeneity and age-related changes are not fully understood. This study aimed to compare naïve CD8+ T cell subsets defined by different combinations of markers, namely, NCCR7 (CD45RA+CCR7+), NCD28 (CD45RA+CD28+), NCD27…
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SARC-T a new physical test for sarcopenia assessment with development, validation and physiological evaluation
BackgroundSarcopenia is a disease characterized by the progressive loss of muscle mass and strength associated with aging. There are marked differences in sarcopenia prevalence depending on the diagnostic algorithm used. It has been demonstrated that muscle power is the most relevant predictor for…
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Artikel Jurnal
Anshen Bunao syrup as a potential anti-aging agent: mechanistic insights and pharmacological evidence
BackgroundAnshen Bunao Syrup (ABS) is a commonly used traditional Chinese patent medicine for insomnia and amnesia, and also has the potential to anti-aging but lacks scientific support of pharmacological and mechanism research. This study aims to investigate the anti-aging effect of ABS and its…
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Artikel Jurnal
Evaluation of bempedoic acid in elderly patients: real-world evidence from the REALIST study
Statin intolerance and PCSK9 inhibitor reimbursement restrictions limit lipid-lowering options for elderly patients at high cardiovascular (CV) risk. Bempedoic acid (BA), an ATP-citrate lyase inhibitor, is a promising alternative. This study analyzed 54 patients over 81 years, selected from 2,564…
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Artikel Jurnal
First metagenomic analysis of age-associated changes in the gut microbiome among healthy Saudi adults: SAMS pilot study
IntroductionThe gut microbiome undergoes dynamic changes with aging across diverse healthy populations. However, data from Saudi Arabia remain limited. This pilot study investigated age-related variations in the gut microbiome among healthy Saudi adults to characterize region-specific microbial…
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Effects of age, sex, and sensory information on balance performance in young and older adults
BackgroundThis study aimed to comprehensively investigate the independent and interactive effects of age, sex, and sensory information on balance control in young and older adults.MethodsA total of 250 participants, stratified into five age groups (25–40, 60–65, 66–70, 71–75, and 76–80 years) with…
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Artikel Jurnal
Determining optimal Barthel Index cutoff scores for predicting Longshi Scale grades across age groups in stroke patients
BackgroundThe Barthel Index (BI) is a standard, widely used measure of dependence in activities of daily living (ADL), particularly in stroke care. The Longshi Scale (LS) offers a simpler, more user-friendly alternative; however, it lacks a validated, age-stratified mapping to BI scores. This gap…
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The gut and circulating virome: emerging players in aging and longevity
A growing body of evidence indicates that the human virome, comprising both the gut and circulating viral communities, plays a critical role in shaping host physiology across the lifespan. In the context of aging, this complex viral ecosystem is increasingly recognized as a key modulator of immune…
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Artikel Jurnal
Obesity and low lean mass are associated with dysregulated IGFBP-3, inflammatory biomarkers, and physical impairment in older adult women with frailty
IntroductionPrior studies indicate sex-specific obesity-frailty interactions, with postmenopausal estrogen decline increasing sarcopenic obesity risk and inflammation in women. This study evaluated circulating cytokines (IL-6, TNF-α), adipokines (adiponectin, resistin), myokines (GDF-15, BDNF…
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Artikel Jurnal
One-month early time-restricted eating mitigates brain aging and enhances memory in males with metabolic syndrome: an MRI structural study
BackgroundMetabolic syndrome (MetS) has emerged as a global health concern challenges to human brain aging and memory function. While early time-restricted eating (eTRE) has been widely recognized as an effective dietary approach for improving metabolic regulation, its potential influence on brain…
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Artikel Jurnal
Cardiovascular risk factor changes associated with six-year circuit training in older adults: a retrospective cohort analysis
BackgroundPhysical exercise can significantly impact chronic disease prevention and health promotion in older adults. This retrospective cohort study evaluated the association between participation in a multidisciplinary physical exercise program and cardiovascular health outcomes in older adults…
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Effect of milk and dairy intake on cognitive function in older adults: a systematic review and meta-analysis
IntroductionCognitive aging represents a growing challenge for global public health. Nutrition could have a beneficial effect in preserving cognitive function, and dairy products have been proposed as neuroprotective due to their nutrient density and bioactive compounds. In this systematic review…