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Scopus
ISSN 2673-6357 · MDPI AG · 238 artikel di indeks
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Artikel Jurnal Teks lengkap
Emperipolesis of Erythroid Cells in Acute Myeloid Leukaemia with Myelodysplasia-Related Changes: A Case Report and Literature Review
Emperipolesis, a cell-in-cell phenomenon, involves a viable cell being transiently internalized within another cell’s cytoplasm from which it can exit without damaging either cell. In this report, we discuss the rarity of the emperipolesis of erythrocytes and erythroblasts, instead of the more…
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Acute Myeloid Leukemia in Older Adults: A Comprehensive Narrative Review of Risk Stratification and Treatment Advances
Acute myeloid leukemia (AML) is predominantly a disease of older adults, with a median age at diagnosis of 68–72 years. Management in this population is complicated by adverse cytogenetic and molecular features, higher rates of secondary disease, and patient-specific factors such as comorbidity and…
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Complex Karyotype and TP53 Alterations in AML and MDS
Background/Objectives: A complex karyotype (CK) in acute myeloid leukemia (AML) and myelodysplastic syndromes (MDSs) is defined as the presence of three or more unrelated chromosomal abnormalities in the absence of defining core-binding factor translocations. Losses/Deletions on chromosomes 5, 7…
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C-Reactive Protein-to-Albumin Ratio and Its Association with Inflammatory and Renal Parameters in Multiple Myeloma
Background: Multiple myeloma (MM) is a hematological malignancy characterized by systemic inflammation and frequent renal involvement. The C-reactive protein-to-albumin ratio (CAR) has emerged as a potential inflammation-based biomarker; however, its clinical significance in MM remains incompletely…
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Real-World Survival Outcomes of Hypomethylating Agents and Allogeneic Hematopoietic Stem Cell Transplantation in Myelodysplastic Syndromes: A Retrospective Single-Center Experience
Background: Treatment strategies for myelodysplastic syndromes (MDS) range from supportive care to disease-modifying therapies, depending on risk stratification and patient characteristics. Hypomethylating agents (HMAs) remain the standard treatment for higher-risk disease, whereas allogeneic…
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Assessment of Nutritional Status in Adult Patients with Acute Myeloid Leukemia: The Role of Screening Tools, Composite Indices, Body Composition, and Physical Function—A Structured Narrative Review
Nutritional deterioration in adults with acute myeloid leukemia (AML) may be present at diagnosis and may evolve rapidly during intensive chemotherapy, lower-intensity treatment, and allogeneic hematopoietic cell transplantation (allo-HCT). This structured narrative review critically examines…
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Pharmacogenetic Profiling of Allogeneic Stem Cell Transplantation Patients: An Exploratory Descriptive Study
Background/Objectives: Patients receiving allogeneic hematopoietic stem cell transplantation (alloHCT) for acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) are at high risk for severe disease and treatment-related complications and toxicities. Pharmacogenetic studies suggest that…
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Auto Transfusion-Can It Be Used as an Alternative to Pre-Hospital Fresh Blood in Severe Shock Where Blood Is Not Available?
Pre-hospital use of whole blood is becoming increasingly prevalent in EMS and military medicine. Technologies to store, transport, warm up, and transfuse the blood are now available, and the outcome of whole blood transfusion seems to be superior to infusion of crystalloid solutions or plasma and…
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Flow Cytometry Immunophenotyping in Hematology Clinical Practice: Panacea or a Diagnostic Tool? Conclusions from a Case Report
Flow cytometry is an essential diagnostic method in hematology, and one of its main applications is the assessment of the clonality of mature B cells. We present a case report of a patient referred for the investigation of absolute lymphocytosis. The flow cytometry study revealed an increased…
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Age-Associated Changes in Mean Corpuscular Volume and Leukocyte Ratios in U.S. Adults
Background: The associations between mean corpuscular volume (MCV) and leukocyte-derived ratios and chronological aging remain poorly understood. We aimed to evaluate the association between MCV and leukocyte-derived ratios and chronological age in U.S. adults. Methods: This cross-sectional study…
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Second Primary Malignancies After Primary Gastric Lymphoma: Incidence, Risk Factors, and Clinical Implications
Survivors of primary gastric lymphoma (PGL) face a significantly elevated and persistent risk of developing second primary malignancies (SPMs), with gastric adenocarcinoma representing the most frequent SPM and standardized incidence ratios reaching up to 16-fold above the general population. This…
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Redefining Caregiver and Patient Resilience in Hematologic Malignancies: A Narrative Review
Background: In hematologic malignancies, treatment allocation and outcome prediction are traditionally driven by clinical and biological parameters. However, growing evidence suggests that non-clinical factors—such as psychosocial context, caregiver availability, organizational support, and digital…
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Acute Myeloid Leukemia Following Mantle Cell Lymphoma: Clonal Evolution Versus Therapy-Related Pathogenesis—A Case Report with Longitudinal Molecular Tracking
We report a female in her late 80s with high-risk pleomorphic mantle cell lymphoma (MCL) harboring germline ATM mutation and 17p deletion who achieved complete metabolic response with zanubrutinib plus rituximab. Serial peripheral blood next-generation sequencing (NGS) during remission revealed…
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Primary Myelofibrosis vs. Multiple Myeloma-Associated Bone Marrow Fibrosis: When Treatment Response Clarifies the Diagnosis
Introduction: The concomitant occurrence of myeloproliferative neoplasms (MPNs) and plasma cell dyscrasias is rare and presents significant diagnostic challenges. Accurate distinction between overlapping features is essential, particularly when bone marrow fibrosis (BMF) is present. Case…
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Hematological Profile of Patients with Clostridioides difficile Infection: Clinical and Prognostic Implications
Background/objectives. Clostridioides difficile infection (CDI) remains a major cause of healthcare-associated infectious colitis, particularly among elderly and multimorbid patients. Disease severity and clinical evolution are influenced by the host’s systemic inflammatory response. This study…
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Platelet Function and Morphology in Patients with Sepsis and Septic Shock: A Retrospective Pilot Study
Background: Sepsis remains a leading cause of mortality in the intensive care unit (ICU). Platelets (PLTs) are central to coagulation, inflammation, and the maintenance of endothelial integrity. Although thrombocytopenia is an established prognostic marker in sepsis, alterations in PLT function and…
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Real-World Outcomes of Venetoclax in Relapsed/Refractory Chronic Lymphocytic Leukemia
Background: Chronic lymphocytic leukemia (CLL) is a biologically heterogeneous disease characterized by variable clinical outcomes. The introduction of targeted therapies, particularly the BCL-2 inhibitor venetoclax, has significantly improved treatment outcomes in patients with relapsed/refractory…
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From Resistance to Vulnerability: Therapy-Induced Surface Receptor Plasticity in ALL as an Immunotherapeutic Opportunity
Acute lymphoblastic leukemia (ALL) is a genetically and epigenetically heterogeneous malignant disease characterized by different subtypes with varying sensitivities to conventional chemotherapy. Despite significant improvements in survival rates, relapse remains the primary cause of treatment…
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Blastic Plasmacytoid Dendritic Cell Neoplasm in the Era of Targeted Therapies
Blastic plasmocytoid dendritic cell neoplasm (BPDCN) is a rare myeloid malignancy, characterized by the involvement of multiple organs, including the skin, bone marrow and blood, lymph nodes and the central nervous system. According to tumor location, the disease is classified as skin-only…
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A Pragmatic First-Line Screening Assay for PDGFR Rearrangements: A Real-World Clinical Validation
Myeloid/lymphoid neoplasms with tyrosine kinase rearrangements (MLN-TKs) are rare clonal eosinophilias driven by PDGFRA, PDGFRB and other kinase fusions, highly sensitive to tyrosine kinase inhibitors. Their detection remains challenging, particularly for cryptic PDGFRA rearrangements. We performed…