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Frontiers in Virology
Scopus
ISSN 2673-818X · Frontiers Media S.A. · 318 artikel di indeks
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Artikel Jurnal
A next-generation strategy for HIV-1 vaccination: computational design of a multi-epitope subunit vaccine targeting global circulating variants
Despite decades of research, no effective cure or preventive vaccine exists for human immunodeficiency virus type 1 (HIV-1). To address this gap, this study aimed to design a universal multi-epitope subunit vaccine (MESV) targeting conserved and immunogenic epitopes across diverse HIV-1 variants…
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Multicompartment modeling of influenza A replication along the murine respiratory tract
Influenza A virus spreads through the respiratory tract in a compartment-specific manner, yet the mechanisms governing its progression remain unclear. Here, we investigated how viral replication and inter-compartment transport shape infection dynamics across the nose, trachea, and lungs. To address…
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Honeybee venom therapy and viral infection: a systematic synthesis of venom antiviral activity
The bioactive components of honeybee venom (HBV) have displayed broad evolutionary antiviral activity in animal models; however, there is limited evidence for the efficacy, indications, or side effects of the use of HBV in humans. We performed a systematic review and meta-analysis of the available…
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Distinguishing the clinical types and laboratory markers of the ancestral and Omicron variants of COVID-19: a multicenter retrospective study
ObjectiveOmicron has become a dominant variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) worldwide. A majority of individuals infected with Omicron SARS-CoV-2 experience no or mild symptoms, but exhibit excessively higher transmissibility than those infected with the ancestral…
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Immunoinformatics-guided design and in silico evaluation of BAFF- and APRIL-adjuvanted multi-epitope vaccine candidates against human metapneumovirus
IntroductionHuman metapneumovirus (HMPV) is a leading cause of acute respiratory tract infections in infants, older adults, and immunocompromised individuals; however, no licensed vaccine is currently available. This study employed an immunoinformatics-guided reverse vaccinology approach to design…
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Subcellular mapping of ToBRFV movement protein in Nicotiana glutinosa via confocal laser scanning microscopy and agroinfiltration
Movement proteins (MPs) are essential for plant virus spread, mediating cell-to-cell transport through plasmodesmal connections. A plethora of studies have been reported for molecular characterization of Tobamovirus fructirugosum (tomato brown rugose fruit virus, ToBRFV) and its interactions with…
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Molecular systems of emerging viruses: replication, host immune evasion, cross-species adaptation and precision countermeasures
Emerging and re-emerging viruses are difficult to anticipate because epidemic potential emerges from interacting molecular, ecological and social processes. This narrative review critically synthesises evidence published from 2017 to July 2026 on entry, replication, assembly, innate immune evasion…
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Enzyme-mediated site-specific functionalization of mRNA-containing TMV nanorods produced in yeast
Virus-like particles (VLPs) derived from Tobacco mosaic virus (TMV) have emerged as attractive platforms for nanotechnology and molecular delivery applications owing to their robust self-assembly, stoichiometric precision, and highly accessible surface architecture. Here we report the development…
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Inflammation, immune dysfunction and viral disease: could micro- and nanoplastics be the missing link?
The ubiquity of Micro- and nanoplastics (MP/NPs) pollution has reached a critical point, with these synthetic particles now detected across all environmental compartments and within human systemic circulation. As the global landscape faces an escalating frequency of viral outbreaks, there is an…
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Hantaviruses at an inflection point: scientific evidence, spillover risk, and One Health approach
Hantaviruses are zoonotic RNA viruses that cause hemorrhagic fever with renal syndrome and hantavirus cardiopulmonary syndrome and are primarily maintained in rodent reservoirs. Transmission to humans occurs mainly by inhalation of aerosolized excreta from infected rodents, but Andes virus uniquely…
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Mass-standardised antibody concentration and affinity immunity endotypes to the spike protein of SARS-CoV-2 variants in a high-exposure cohort
IntroductionSchool staff members are uniquely exposed to asymptomatic infections in children when in enclosed, poorly ventilated environments. Prevalence of SARS-CoV-2 amongst school children in the Omicron wave was high, leading to a constant, high exposure of teachers to the virus.MethodsA cohort…
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Artificial miRNA-based silencing of begomovirus gene confers resistance to cotton leaf curl disease in cotton
BackgroundCotton leaf curl disease (CLCuD), caused by a complex of begomoviruses and their associated betasatellites, severely reduces cotton productivity. Conventional breeding approaches have shown limited success due to the rapid evolution of viral populations and the involvement of the long…
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Porcine rotavirus type A VP8 protein: an antigen with dual functions as a subunit vaccine and serological diagnostic agent, from receptor binding to mucosal and systemic immunity
Porcine group A rotavirus (PoRVA) continues to be a significant cause of neonatal diarrhea in pigs, affecting swine production globally. VP8*, the glycan-binding domain of VP4, is crucial for viral attachment and immune activation. The dual role of VP8* makes it a promising candidate for vaccines…
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Prevalence of pre-diabetes, newly diagnosed diabetes, and associated COVID-19 disease severity in patients hospitalized at Sir Ketumile Masire Teaching Hospital, Botswana
BackgroundThe mechanism of diabetes with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and onset in COVID-19 patients remains unclear. We aimed to determine the prevalence of pre-diabetes and newly diagnosed diabetes, and to assess their association with COVID-19 disease severity in…
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Molecular epidemiological analysis of lumpy skin disease virus isolates from recent outbreaks in India
IntroductionLumpy skin disease virus (LSDV) is an emerging transboundary pathogen causing severe economic losses in cattle. Continuous molecular surveillance is essential to understand the evolution and spread of circulating strains in India.MethodsClinical samples, including nasal swabs, blood…
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An eco-evolutionary perspective on endemic persistence and invasive emergence of begomoviruses in Mexico
Here we present a conceptual eco-evolutionary perspective on begomovirus emergence, motivated by the observation that these globally important plant DNA viruses of tropical and subtropical agriculture are frequently interpreted through isolated, pathogen-centered case studies. We propose a broader…
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Immuno-pathological studies of lumpy skin disease outbreaks in cattle
IntroductionLumpy skin disease (LSD) is a transboundary viral disease of cattle caused by the lumpy skin disease virus (LSDV), leading to significant economic losses in livestock.MaterialsThe present study investigated the clinical, hematological, and pathological alterations and expression of…
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Global burden, economic impact, and management strategies for re-emerging dengue virus infections: a systematic review
BackgroundDengue is a rapidly expanding mosquito-borne viral disease that imposes substantial health and economic burdens across endemic regions. Although numerous studies have evaluated the cost of dengue illness and prevention strategies, a comprehensive synthesis integrating economic evidence…