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Frontiers in Nuclear Medicine
Scopus
ISSN 2673-8880 · Frontiers Media S.A. · 148 artikel di indeks
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Artikel Jurnal
Pittsburgh compound B positron emission tomography detects cardiomyopathy in hereditary transthyretin amyloidosis patients with negative bone scintigraphy: a pilot study
PurposeTo evaluate the effectiveness of positron emission tomography (PET) with [11C]-Pittsburgh Compound-B ([11C]PiB) for detecting transthyretin amyloid (ATTR) cardiomyopathy in patients with transthyretin gene (TTR) variants associated with reduced bone scintigraphy sensitivity, and its ability…
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Improved random coincidence estimation including triple coincidence detection in PET
Coincidence detection in PET is inherently prone to misidentification due to the presence of randomly occurring singles from different decays within the coincidence time window. Random triple coincidences, arising when three singles from at least two decays are detected within this window, can lead…
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Incidental detection of PDAC via 18F-PSMA PET/CT in a patient with recurrent prostate cancer. A case report
IntroductionProstate specific membrane antigen (PSMA) is a type II transmembrane protein overexpressed in the neovasculature of some pancreatic ductal adenocarcinoma (PDAC). PET/CT can detect this expression and has now become an essential tool in this context. However, this antigen can also be…
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Conceptual proposal for LLM-generated FDG PET/CT follow-up reports in melanoma: a pilot study on model stability and blinded expert evaluation
PurposeOncological patients regularly undergo PET/CT re-staging, which requires a report that outlines their current disease status and highlights relevant changes compared to the previous PET/CT. Large language models (LLMs) may be helpful with documentation in the future. This study is a pilot on…
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Artikel Jurnal
Radiobiological evaluation of the therapeutic effect of silver-111 for the ISOLPHARM project
Introduction:The ISOLPHARM project has the aim of developing novel radiopharmaceuticals using the wide choice of radionuclides produced by Isotope Separation OnLine (ISOL) at LNL-INFN in the SPES facility, which is currently nearing completion. One of the most promising candidates for Targeted…
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Artikel Jurnal
Rethinking dynamics: static amino acid PET parameters vs. dynamic amino acid PET parameters for the detection of tumor progression in patients with post-treatment glioma
BackgroundIt remains unclear whether dynamic amino-acid (AA) positron-emission tomography (PET) has additional diagnostic value over static AA-PET to distinguish tumor progression (TP) from treatment-related abnormalities (TRA) in patients with post-treatment glioma.MethodsThis was a retrospective…
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Absolute stress myocardial blood flow is reduced in patients with prior cardiac disease despite normal perfusion and ejection fraction on rubidium-82 PET: an Arabian Gulf cohort
PurposeRubidium-82 (⁸2Rb) PET is typically interpreted using perfusion category and left ventricular ejection fraction (LVEF), but absolute myocardial blood flow (MBF) and flow reserve (MFR) may add information. We investigated whether absolute stress MBF differs between patients with and without…
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Long vs. short axial field-of-view PET scanners for brain imaging: a phantom study
Long axial field-of-view (LAFOV) PET scanners offer substantially higher sensitivity compared to conventional short axial field-of-view (SAFOV) systems, potentially enabling reduced injected activity, shorter acquisition times, and improved signal-to-noise ratios in brain imaging. However, given…
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Availability, accessibility, and economic feasibility of radionuclide therapies in Africa: a systematic review and quantitative infrastructure analysis
PurposeAfrica faces a projected doubling of cancer burden by 2040, yet access to radionuclide therapies remains critically limited. This systematic review quantifies the availability, accessibility, and economic feasibility of therapeutic nuclear medicine across 54 African nations.MethodsThis study…
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Artikel Jurnal
Physiological biodistribution of 18F-fluciclovine PET in the head: as a baseline for interpretation in patients with suspected glioma
IntroductionAnti-1-amino-3-[18F] fluorocyclobutane-1-carboxylic acid (18F-fluciclovine; anti-3-[18F] FACBC) is an amino acid positron emission tomography (PET) tracer used for the evaluation of brain tumors in cases of suspected or diagnosed glioma. While its uptake characteristics in brain tumors…
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Driving clinical excellence through a management driven framework for integrating nuclear medicine into hospital ecosystems
PurposeNuclear medicine (NM) often functions as an isolated diagnostic island within hospitals, resulting in the underutilization of high-value molecular imaging resources despite their significant clinical potential. This paper proposes a conceptual management-driven framework, termed the…
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Impact of reader experience on the time-saving potential of a novel computer-aided tool for Ann Arbor staging of pediatric hodgkin lymphoma
BackgroundAccurate staging of Hodgkin lymphoma in children is important for selecting appropriate therapies. However, evaluation of Ann Arbor staging criteria on whole-body 18F-FDG PET scans is time-consuming and subject to reader-dependent variability.ObjectiveTo determine if a novel…
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Artikel Jurnal
Artificial intelligence across oncologic theranostics: evidence for patient stratification, dosimetry, and adaptive radiopharmaceutical therapy
Artificial intelligence (AI) has been studied across radiopharmaceutical therapy (RPT); however, evidence for treatment-changing use remains limited. We conducted a structured narrative review with descriptive mapping of learned models for patient stratification, segmentation, tumor-burden…
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Quantification in bone SPECT/CT
BackgroundQuantitative bone SPECT/CT enables objective assessment of skeletal radiotracer uptake using standardised uptake values (SUVs) and related parameters. Advances in reconstruction, correction methods, calibration and detector technology have improved measurement reliability and expanded…
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Case Report: Role of MRI, CT, and 18F-FDG PET/CT in staging and response assessment of pediatric synovial sarcoma
Synovial sarcoma is a rare and aggressive soft tissue malignancy that predominantly affects adolescents and young adults. Early diagnosis can be challenging due to nonspecific clinical presentation and the heterogeneous imaging appearance of these tumors. Multimodal imaging plays a central role in…
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Artikel Jurnal
Cross-Domain TransNet for sparse-view CT reconstruction
IntroductionSparse-view computed tomography (CT) reconstruction is crucial for clinical diagnostics, as reducing radiation exposure is essential to minimize risks to patients. Existing dual-domain reconstruction methods leverage both image and projection domains but often process them sequentially…
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Prognostic value of baseline 18F-FDG PET/CT metabolic parameters in EGFR-mutant lung adenocarcinoma patients treated with EGFR-TKIs
ObjectiveTo investigate the correlation between baseline 1⁸F-FDG PET/CT metabolic parameters and progression-free survival (PFS) in EGFR-mutant lung adenocarcinoma receiving EGFR-TKI treatment, with subgroup analysis for exon 19 deletion (19del) and L858R mutations.MethodsThis single-center…
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Dual-domain transformer-based learned primal-dual reconstruction for PET imaging
Background and ObjectivePositron Emission Tomography (PET) is widely used for assessing metabolic activity and diagnosing cancer. Due to the inherently high noise levels in PET data, advanced reconstruction algorithms are essential for accurate imaging. Convolutional Neural Networks (CNNs) within…