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Frontiers in Systems Biology
Scopus
ISSN 2674-0702 · Frontiers Media S.A. · 187 artikel di indeks
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Artikel Jurnal
Streamlining IRB review of AI human subjects research (AIHSR): the three-stage framework
Oversight of Artificial Intelligence in Human Subjects Research (AI HSR) presents unique challenges. These challenges arise from both the non-linear and iterative nature of AI development, as well as from the way AI shifts risk from individual research subjects to larger populations affected by…
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Avian cecal microbiome response and resilience to Newcastle disease are dictated by breed background
A wide range of viral infections threaten the long-term sustainability of poultry production. Newcastle disease (ND), caused by Newcastle disease virus (NDV), is endemic in most Asian countries, including Pakistan, causing 50%–100% mortality in young and mature chickens. Some local chicken breeds…
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Mathematical modeling of bone remodeling after surgical menopause
Osteoporosis is a skeletal pathology characterized by decreased bone mass and structural deterioration resulting from an imbalance in bone metabolic processes. Estrogen deficiency in postmenopausal women leads to an increased risk of osteoporosis, while women who have undergone complete…
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Genetic determinants of tendon and ligament injuries in athletes: a narrative review from single variants to gene-gene interactions
Tendon and ligament injuries are common in athletes and can result in significant functional impairment. Genetic factors are increasingly recognized as key contributors to individual susceptibility. A structured narrative literature search was conducted in PubMed, Scopus, Web of Science, and Google…
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Latent multimorbidity classes and antithrombotic medication distributions among patients hospitalized for bleeding after dental surgery: a retrospective study
ObjectivesTo characterize patients hospitalized for postoperative intraoral bleeding after dental surgery and to describe latent multimorbidity classes and their observed antithrombotic medication distributions.Materials and MethodsThis single-center retrospective study included 700 patients…
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GPCR signaling systems facilitate precision interventions for multi-oncology therapy
Precision oncology has undergone a transformative evolution from static genomic profiling toward dynamic, multi-omics frameworks capable of capturing tumor heterogeneity and adaptive resistance in real time. Central to this paradigm shift is the emerging recognition that G protein-coupled receptors…
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Explainable artificial intelligence (XAI) in schizophrenia: enhancing transparency in clinical decision-making
Schizophrenia is a chronic and severe psychiatric disorder affecting nearly 1% of the global population, characterized by positive symptoms such as hallucinations and delusions, negative symptoms including avolition and affective flattening, and cognitive impairments that compromise social and…
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Targeting gut dysbiosis: a new frontier in MASLD management
Globally, Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prominent leading cause of CLD, which is intricately linked with obesity, T2D, and metabolic syndrome. Recent insights in pathophysiologically of MASLD have shifted from the traditional “two-hit” model to a…
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Generative models of living development: an interaction-centered proposal and its implications for artificial life research
Artificial life and integrative systems neuroscience increasingly seek to explain how agency is organized through development, not merely how an already-formed controller optimizes a predefined task. This article advances an interaction-centered theory that links computational generative models…
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Decoding endurance performance: integrative genomic and epigenetic insights into the molecular basis of athletic adaptation
Applied genomics in sports performance has rapidly evolved into a multidisciplinary field aimed at elucidating the biological determinants of complex athletic traits, particularly endurance. Endurance performance represents a highly polygenic and multifactorial phenotype, shaped by the dynamic…
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The causal integration ladder: a multilevel evidence framework for therapeutic target evaluation in cervical cancer
Cervical-cancer genomic studies nominate many altered genes, but the evidence needed to distinguish disease association from a causal, therapeutically tractable mechanism is rarely stated explicitly. We present the Causal Integration Ladder (CIL), an evidence-accounting framework that distinguishes…
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The archibiome: extending engineered living materials to multiscale built environments
The integration of living systems into architecture is advancing rapidly through developments in biotechnology, materials science, and design approaches grounded in regenerative principles. Engineered Living Materials (ELMs) and living artefacts demonstrate how microbial systems can be embedded…
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Integrating clinical knowledge to preserve clinical coherence in health systems
Modern health systems generate, store, and analyze unprecedented biological information, yet translating it into coherent longitudinal care remains difficult. Fragmentation across encounters, specialties, organizations, and digital systems contributes to delayed diagnosis, inconsistent…
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Glioma identification from microRNA biomarkers using machine learning
Gliomas are the most aggressive malignant brain tumours, occurring mostly in adults and accounting for approximately 80% of central nervous system malignant tumours. Traditional diagnostic methods are both invasive and expensive, thus accurate, minimally invasive, and cost-effective early detection…
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Quorum-quenching for bacterial pathogen control and health management in aquaculture: mechanisms, applications, current status and future prospects
The aquaculture sector has grown rapidly in recent years, and it now has a significant impact on global food and nutritional security. Infectious disease outbreaks in aquaculture cause significant losses and also threaten the sustainability. Despite the antimicrobial resistance (AMR), environmental…
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Multilayer network approaches to omics data integration in digital twins for cancer research
How can we effectively integrate and represent heterogeneous multi-omics data to better understand complex biological systems and support the development of personalized digital models? The growing availability of high-dimensional omics data across different molecular scales presents both…
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Multi-OCT-SelfNet: integrating self-supervised learning with multi-source data fusion for enhanced multi-class retinal disease classification
Acquiring large and diverse medical imaging datasets remains challenging because of privacy, annotation cost, and institutional variability. This limitation can reduce the generalization ability of deep learning models, particularly when they are trained on small or domain-specific retinal…
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Computational analysis and validation of UGT1A1/4 missense variants impacting tecovirimat metabolism in monkeypox patients
IntroductionSingle nucleotide polymorphisms (SNPs) in genes encoding drug-metabolizing enzymes can significantly impact a patient’s response to medication. Uridine diphosphate glucuronosyltransferase 1 family A1 and A4 (UGT1A1/4) are crucial enzymes for metabolizing tecovirimat, the first oral…
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From biological surfaces to engineered systems: how synthetic and systems biology enable biomimetic design
Biological surfaces perform a wide range of functions, including communication, molecular exchange, defense, and movement. While these architectures have long inspired biomimetic surface engineering, most existing reviews focus on fabrication methods, often overlooking the biological mechanisms…
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Functional saturation of Earth’s habitable domains: constraints on land systems and potential in marine environments
In this context, functional saturation is defined as the state in which a system’s capacity to sustain additional productive or regulatory functions becomes constrained due to cumulative anthropogenic pressures, even if some physical space remains available. This review examines whether the…