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Bacteria
Scopus
ISSN 2674-1334 · MDPI AG · 169 artikel di indeks
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Hydroquinine, a Cinchona Alkaloid, Exhibits Antibacterial Activity Against Pathogenic Bacteria by Targeting the Arginine/Ornithine Antiporter (AOA) in the ADI Pathway
Hydroquinine, a cinchona alkaloid, has demonstrated antibacterial activity against multidrug-resistant pathogens, with previous transcriptomic data implicating the arginine deiminase (ADI) pathway. However, its potential molecular target engagement remains to be fully characterized. This study…
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Development and Validation of a Specific and Sensitive Quantitative PCR Assay for the Detection of the oprD Cassette in Pseudomonas aeruginosa Clinical Isolates
Carbapenem resistance in Pseudomonas aeruginosa is frequently mediated by the mutational inactivation or complete loss of the oprD porin gene. However, extreme genetic polymorphism within oprD limits traditional PCR amplification, a bottleneck for molecular surveillance. This study aimed to design…
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Stunting Is Associated with Altered Periodontal Host–Microbe Interactions and Responses to Oral Probiotic and Antiseptic Interventions in Children
Objectives: To determine whether stunting modifies periodontal microbial dynamics, inflammatory responses, and short-term responses to oral interventions in children. Materials and Methods: This open-label, non-randomized study included 36 children aged 8–12 years, comprising 18 children with…
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Comparison of Two Active Doses of Microencapsulated Lacticaseibacillus rhamnosus GG in a Yoghurt Drink on Gut Microbiome Profiles in Healthy Adults: A Randomised, Double-Blind Crossover Trial
Probiotic efficacy may depend on reliable intestinal exposure, yet clinical evidence linking delivery engineering to measurable microbiome responses in humans remains limited. We compared two active doses of microencapsulated Lacticaseibacillus rhamnosus GG in 26 healthy adults in a randomised…
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Patterns of Gardnerella vaginalis Co-Detection with Ureaplasma urealyticum and Ureaplasma parvum in Adult Urogenital Molecular Testing in the Republic of Korea, 2018–2022
Multiplex PCR assays report Ureaplasma urealyticum (UU) and Ureaplasma parvum (UP) separately, but the results are often combined as “Ureaplasma positive.” We compared Gardnerella vaginalis (GV) co-detection in UU-only and UP-only adult specimen accession records and examined variation by sex and…
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Biodegradation of Congo Red and Orange G by Bacillus cereus from the Saida Dumpsite: Experimental and In Silico Evidence
Understanding the potential mechanisms of bacterial azo dye decolorization remains a challenge due to a limited understanding of the exact stereochemical forces guiding enzyme–substrate interactions. This study addresses these interactions by evaluating the in silico binding architectures of Orange…
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Genomic Analysis of the Type VII Secretion System (T7SSb) Proteins in Staphylococcus aureus Isolates from Raw Meat, Processed Meat Products and Veterinary Samples of Food-Producing Animals
Staphylococcus aureus (S. aureus) produces an array of virulence factors (VFs), which contribute to its pathogenicity. One of the VFs is the type VII secretion system (T7SS), a protein secretion apparatus present in many Gram-positive bacteria, which plays a major role during the onset of…
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Shotgun Metagenomic Assessment of Raw and Treated Wastewater from a Public Oncology Hospital in Paraguay: Treatment-Associated Shifts in DNA-Based Bacterial Profiles and Resistome Signatures
Hospital wastewater is an important matrix for monitoring clinically relevant bacteria and antimicrobial resistance genes (ARGs). We used shotgun metagenomic sequencing for an exploratory comparison of untreated wastewater and treated effluent from a public oncology hospital in Paraguay during four…
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Stress-Induced Protein Networks in Extremophilic Prokaryotes: Integrating Proteomics and Functional Genomics
Extremophilic prokaryotes survive salt, temperature, and pH extremes by coordinating stress-induced protein networks that preserve macromolecules, sustain energetics, and repair damage. This review integrates recent proteomics with functional genomics to resolve both network state and causality…
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Analysis of Multidrug-Resistance and Resistant Genes in Escherichia coli Isolates from Raw Beef: A Meta-Analysis
Beef is an excellent source of protein in the human diet; however, high production levels in the livestock industry expose meat products to a greater risk of contamination by bacteria such as Escherichia coli, a pathogen of great significance in public health due to its widespread distribution and…
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Exploratory Assessment of Oral Microbiome Dysbiosis Associated with Chronic Smokeless Tobacco Use: A Sibling-Based Study
Smokeless tobacco (SLT) consumption is a significant risk factor for oral dysbiosis and oral cancer in South Asian countries, including India. However, its impact on oral microbial ecology, functional restructuring, and sex-specific microbial responses remains unclear. The present study aimed to…
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Characterization of Bacterial Diversity in Antarctic Soils Using 16S rRNA Gene Amplicon Sequencing
Antarctic soils harbor highly specialized bacterial communities that perform essential functions in the functioning of polar ecosystems; however, the composition and structure of these communities remain poorly understood in many areas of Antarctica. The objective of this study was to characterize…
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Production of Gamma (γ)-Aminobutyric Acid by Lactic Acid Bacteria and Its Applications in the Food and Health Sectors
Gamma (γ)-aminobutyric acid (GABA) is a non-proteinogenic amino acid recognized for its primary function as the main inhibitory neurotransmitter in the mammalian central nervous system and its role as a stress-responsive metabolite in various microorganisms. This review critically examines the…
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Optimizing Cryoprotective Formulations to Enhance Freeze-Drying Survival of Soybean-Associated Beneficial Bacteria
One of the challenges in the practical application of plant growth-promoting bacteria (PGPB) is predicting their effectiveness under field conditions. Performance can vary due to environmental factors and the recruitment of genotype-specific microbiota through root exudates. In addition, the…
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Bovine Bile and Oxygen Availability Impact Escherichia coli O157:H7 Metabolism and Adherence Factor Expression
Escherichia coli O157:H7 represents a major food safety concern, with cattle serving as the primary reservoir host. A better understanding of the interactions between O157 and the potential physiochemical indicators to which it is exposed to in the cattle hindgut would lend insight into the O157…
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Long-Term Immune Responses and Disease Protection in Asian Seabass (Lates calcarifer) Following Sequential Nanoemulsion and Oral Hydrogel Mucosal Vaccination Against Multiple Bacterial Pathogens
Aquaculture production of Asian seabass is increasingly threatened by recurrent bacterial diseases, while practical vaccination strategies that provide protection against bacterial challenges involving multiple pathogens during extended grow-out periods remain limited. This study evaluated the…
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Stress-Responsive Regulatory Networks in Legume–Rhizobium Symbiosis: Implications for Climate-Smart Agriculture
Legume–rhizobium symbiosis is fundamental to sustainable agriculture because it supplies biologically fixed nitrogen, improves soil fertility, and reduces reliance on synthetic fertilizers. However, abiotic and chemical stresses, including drought, salinity, flooding, temperature extremes, heavy…
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Ancient Yet Alive: Stable Molecular Networks and Precellular Polymer Consortia as Frameworks for Alternative Hereditary Systems Before LUCA
The origin of life is commonly framed within the RNA World hypothesis, yet increasing evidence suggests that early evolution may have involved a broader diversity of hereditary systems than those preserved in modern biology. Alternative informational polymers, compositional inheritance…
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Comparative Genomics of a Hemolymph-Derived Pseudomonas boreofloridensis Strain RAC1 Reveals Metabolic Versatility and Multidrug Resistance
Flacherie is a major bacterial disease compromising silkworm health and cocoon productivity; however, the diversity and genomic features of larva-associated pathogens remain poorly characterized. In the present study, we isolated and characterized a Gram-negative bacterium, designated as…
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Bacteria: A New Chapter in a Rapidly Evolving Field
Scientific journals are, at their best, reflections of the disciplines they serve [...]