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Research Journal of Applied Biotechnology (2026)
ISSN 2682-3470 · University of Sadat City, Genetic Engineering & Biotechnology Research Institute (GEBRI) · 121 artikel di indeks
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Artikel Jurnal
Chemosensitization of Breast Cancer Cells by Haloperidol: A Synergistic Strategy Targeting Drug Efflux and The Apoptosis pathway
Background/Aim: Patients with breast cancer receiving doxorubicin (DOX) are most likely to experience treatment failure due to multidrug resistance (MDR). Therefore, our goals were to ascertain if haloperidol (HALO) may chemosensitize the MCF-7 breast cancer cell line towards DOX, in addition to…
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The Impact of Chitosan Nanoparticles on Stimulation of the Lupinus albus L. Growth, Productivity and Phyto-Components Content
Nanotechnology represents a promising approach for advancing sustainable agriculture by mitigating global issues such as climate stress, crop diseases, and nutrient deficiency. Among nanomaterials, chitosan nanoparticles (ChNPs) are of particular interest due to their biodegradability…
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Conjugation of Β-Sitosterol to Cupper Sulfide-Folic Acid Nanoparticles for Enhancement of Radiotherapy in MCF-7 and MDA-MB-231 Breast Cancer Cells
Breast cancer is still a primary cause of cancer-related deaths in women, underscoring the vital need for new therapeutic approaches. β-Sitosterol (βST) is a phytosterol known for its anticancer effects, but its clinical application is limited by poor bioavailability. Nanoparticle platforms, like…
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CD34 Positivity and Aberrant Marker Expression by Blasts of B-ALL Patients
Background: Acute leukemia, specifically Acute lymphoblastic leukemia (B-ALL), poses significant diagnostic and therapeutic challenges due to its complex biology and varied antigen expression.Objective: the study aims to analyze CD34 expression prevalence in patients with B-ALL at Shefaa Al-orman…
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Toll like receptor 7 & 9 gene expressions and their relation with HCV-associated renal failure in Egyptian patients.
Background: HCV infection can lead to kidney disease, and renal patients may acquire HCV through hemodialysis. Multiple mechanisms contribute to acute and chronic renal syndromes, and failure are often complicated by HCV infection in advanced stages.Aim: To evaluate the expression levels of TLRs 7…
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Evaluation of Pollen Vitality in Different Sugarcane Genotypes Utilizing Various Techniques and Time Intervals
This study was conducted to contrast two staining techniques for determining pollen viability in sugarcane. At three diverse times (6:30, 8:00, and 9:30 a.m.), pollen from seven sugarcane genotypes was gathered, and its vitality was assessed using Lactophenol blue and Iodine stains. For every…
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In vitro propagation of Potato (Solanum tuberosum L.) using five different genotypes including the production of minitubers and super elite.
Potato (Solanum tuberosum L.) is a vital crop in Egypt, with the country importing approximately 120,000 MT of seed potatoes annually and exporting over 759,200 MT of ware potatoes. This positions Egypt as Africa's leading potato producer. This study investigated the micropropagation of five potato…
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NPM1 Gene Expression as a Molecular Prognostic Marker in Acute Myeloid Leukemia Among Egyptian Patients
Background and objectives: Acute myeloid leukemia is the most prevalent type of leukemia in adults. It is defined by changes in average hematopoietic growth and differentiation, resulting in large numbers of abnormal, immature myeloid cells in the bone marrow and peripheral blood. This study aimed…
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Association of AURKA Polymorphisms with the Development and Progression of Hepatocellular Carcinoma in Egyptian Patients
Hepatocellular carcinoma (HCC) is a highly fatal disease and one of the most prevalent cancers globally. Aurora kinase A (AURKA) also known as STK15, BTAK, and AIKI plays a crucial role in oncogenic processes by promoting mitotic progression and chromosomal stability in centrosomes and mitotic…
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Association of PNPLA3 Gene Polymorphisms with the Development and Progression of Hepatocellular Carcinoma in Egyptian patients"
TThis study aimed to examine the relationship between hepatocellular carcinoma (HCC) susceptibility and two single nucleotide polymorphisms (SNPs) of PNPLA3: rs738409 C > G and rs3747207 G > A. An investigation was carried out on a case-control group of 47 patients with hepatocellular carcinoma…
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Synthesis, characterization and biological activity of cadmium (II) complex of hydrazone moiety
With the aid of hydrazone moiety, a novel Cd(II) chelate with 2-[(4-methylphenyl)amino]-N'-[(Z)-thiophen-2-ylmethylidene]acetohydrazide (H2L) was created and reported. These novel chemicals' structural makeup was clarified through the utilization of spectroscopic and analytical methods. The…
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Assessment of the ameliorative effect of Beta-Carotene against Gibberellic acid toxicity in kidneys of rats using comet assay
This work was aimed to observe the protective role of β-carotene (β-CAR) against renal toxicity induced by gibberellic acid (GA3), a plant growth hormone commonly used in adult male rats. The studied rats were divided into six groups of eight each: group one served as a control, while Groups 2 and…
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Comparative study the effect of irradiation on cobalt complexes before and after irradiation
N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-Pyrazol-4-yl)carbonohydrazonoyl dicyanide(LB) is operated to produce and describe the novel Co(II) complex (CB). The structural compositions of the new compounds were clarified through the utilization of analytical and spectroscopic techniques. This…
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Polymorphic Variations of ACE2 and TMPRSS2 Genes in Egyptian COVID-19 Patients: Correlation with Disease Severity and Sex-Related Gene Variations
Abstract: This research pointed to accessing the polymorphic variations of the ACE2 and TMPRSS2 genes in Egyptian COVID-19 patients and their potential correlation with disease severity. The study involved a total of ninety-six participants, with forty-eight experiencing severe symptoms and an…
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Gene Expression Analysis of ACE2, TMPRSS2, and LZTFL1 in COVID-19 Patients: a pilot study
The objective of this research was to assess gene expression levels of ACE2, TMPRSS2, and LZTFL1 in COVID-19 patients from Egypt and investigate their potential association with the severity of the illness. The study involved ninety-six participants, divided into two groups: individuals…
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Combined sperm selection techniques to boost the success of in Vitro Fertilization (IVF) and Intra Cytoplasmic Sperm Injection (ICSI)
This study aimed to assess the effectiveness of combined methods of Density gradient centrifugation and swim-up (D.G.C/S. U) and Density gradient centrifugation and zeta potential (D.G.C/Z) in semen samples to treat sperm abnormality, decrease DNA fragmentation, and choose one of the best methods…
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Relationship between some H5 commercial vaccines and the highly pathogenic H5N8 avian influenza virus that is recently circulating in Egypt
The prevalence of avian influenza viruses (AIVs) in Egypt has had a devastating effect on the poultry sector. Here, we isolated two HPAI (H5N8) viruses from broiler poultry farms in Menoufia and Dakahlia governorates during the period from November 2020 to December 2021. The phylogenetic profiling…
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An innovative extracellular polysaccharide produced by Egyptian Marine Bacillus licheniformis, and its applications as antibacterial agent.
Twenty-two marine bacterial isolates were collected from the Eastern Harbor (29885 E longitude and 31205 N latitude) located at Alexandria, Egypt selected to produce exopolysaccharides, using the Shene extraction method in 2008. The most potent marine bacterium was identified as Bacillus…
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Isolation of Lactobacillus HBUAS56719 from Black Raspberry Leaves and its in-vitro antidiabetic activity
Probiotics are living bacteria that, when given in sufficient quantities, help the host's health. They are currently recognized as appropriate alternatives to antibiotics in the treatment of animal diseases and the enhancement of animal output. It has several different pharmacological properties…
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Screening of Natural β-lactamase Inhibitors (BLIPs) from Two Newly Isolated Egyptian Streptomyces strains
β-lactam antibiotics are the most extensively used antibiotics to treat a variety of infections due to their safety, high selectivity, and efficacy. However, the main cause of antibiotic resistance is due to the misuse of antibiotics uptake which stimulated bacteria to produce β-lactamases…