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Cerrahpaşa Medical Journal
ISSN 2687-1904 · İstanbul University-Cerrahpasa · 796 articles in the index
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Journal Article
The Impact of Etiological Agents on Clinical Course and Surgical Requirement in Infectious Keratitis: Experience from a Tertiary Referral Center
Objective: To evaluate the etiological distribution, clinical course, and factors associated with surgical requirements in patients with infectious keratitis. Methods: This retrospective study included 119 eyes of 109 patients diagnosed with infectious keratitis at a tertiary referral center…
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Journal Article
Clinical Characteristics of Infants Hospitalized for Neonatal Jaundice: A Retrospective Study
Objective: Neonatal jaundice (NJ) can lead to irreversible brain damage in a small number of infants, and its risk factors vary significantly across geographical regions. Demographic and clinical data of preterm, early term, and term neonates hospitalized solely for NJ were analyzed to describe the…
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Journal Article
Relationship Between Preoperative Systemic Inflammatory Markers and Postoperative Pathological Indices in Supra-tentorial Meningiomas: Analysis of 88 Patients
Objective: To evaluate the correlation between preoperative systemic inflammatory markers and postoperative pathological indices in a group of patients who underwent surgery for supratentorial convexity meningiomas. Methods: Eighty-eight cases served as subjects for this retrospective study…
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Journal Article
Do Future Physicians Know the Duties of District Health Directorates?
Objective: In Türkiye, district health directorates (DHDs) are the peripheral administrative units of the Ministry of Health operating at the district level. The aim of this study is to investigate the knowledge of the fifth and sixth grade students of 2 medical schools about the duties of DHDs…
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Journal Article
Real-World Outcomes of Tyrosine Kinase Inhibitor–Based Therapy in Advanced Thyroid Carcinoma: A Single-Center Retrospective Study
Objective: Advanced thyroid carcinoma includes biologically distinct subtypes with variable clinical behavior, and the outcomes of targeted therapy in routine practice may differ from those reported in clinical trials. This study evaluated the effectiveness and tolerability of tyrosine kinase…
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Journal Article
Potential Use of ChatGPT-4 in Micronutrient Deficiency Management: A Narrative Scoping Review and a Framework for Validation and Safe Deployment
Abstract / Summary Micronutrient deficiencies remain common and clinically important, yet their recognition and management require careful history-taking, appropriate testing, and guideline-concordant counseling. Large language models (LLMs) such as ChatGPT-4 have been proposed as tools that may…
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Journal Article
Clinical and Genetic Features of Congenital Disorders of Glycosylation Presenting with Hereditary Hemolytic Anemia and Prolonged Jaundice
Cite this article as: Solğun HA, Ozay M. Clinical and genetic features of congenital disorders of glycosylation presenting with hereditary hemolytic anemia and prolonged jaundice. Cerrahpaşa Med J. 2026, 50, 0104, doi: 10.5152/cjm.2026.25104.
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Journal Article
Carbon Footprint of Gastrointestinal Endoscopy: A Prospective Procedure-Level Environmental Assessment
Objective: Gastrointestinal endoscopy (GIE) contributes to healthcare-related greenhouse gas emissions; however, prospective procedure-level data remain limited. This study quantified procedure-level emissions and waste and examined operational factors associated with intrinsic…
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Journal Article
Association of TCF7L2 Gene Variants with Glycemic Control During Metformin Therapy in Type 2 Diabetes Mellitus
Objective: The transcription factor 7-like 2 (TCF7L2) gene variants are among the strongest genetic risk factors for type 2 diabetes mellitus (T2DM). However, their influence on glycemic control during metformin therapy remains incompletely understood. This study aimed to investigate variants in…
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Journal Article
Systematic Exploration of Occupational Challenges and Burnout Among Assisted Reproductive Technology Laboratory Managers: A Qualitative Study from Türkiye
Objective: Assisted reproductive technology (ART) laboratory managers play critical roles in fertility treatment success, yet their occupational challenges remain underexplored globally. This study systematically examines the multifaceted problems experienced by ART laboratory managers in Türkiye…
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Journal Article
Clinicopathological Characteristics and Diagnostic Yield of Peripheral Lymph Node Excisional Biopsies in a Tertiary Surgical Oncology Center
Objective: Peripheral lymphadenopathy (LAP) is a common clinical finding with a broad differential diagnosis ranging from benign reactive conditions to malignant diseases. Excisional lymph node biopsy remains the gold standard for definitive diagnosis. This study aimed to evaluate the…
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Journal Article
Bone Mineral Density and Vertebral Fracture Frequency in a Group of Type 1 Diabetic Patients
Objective: This study aimed to evaluate the relationship between vertebral fracture and various biological factors in patients with type 1 diabetes mellitus (T1DM). Methods: The study included 61 patients diagnosed with T1DM who were evaluated in the Diabetes Outpatient Clinic between 2017 and…
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Journal Article
A Case Report and Literature Review: Erythema Multiforme Caused by Zoster Infection
Cite this article as: Gümüş S. A case report and literature review: erythema multiforme caused by zoster infection. Cerrahpaşa Med J. 2026, 50, 0006, doi: 10.5152/cjm.2026.26006.
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Journal Article
Effects of Lithium Chloride and Boric Acid on Cell Viability, Wound Healing, and Oxidative Stress Response in HaCaT Cells and Spheroids
Objective: This study aimed to investigate the effects of lithium chloride (LiCl) and boric acid (BA), administered alone or in combination, on viability, wound healing, spheroid morphology, and oxidative stress-related parameters in Human Adult low Calcium high Temperature keratinocyte cell line…
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Journal Article
Histopathological Spectrum of Postchemotherapy Retroperitoneal Lymph Node Dissection in Testicular Cancer: The Impact of Sampling Adequacy and Viable Nonteratomatous Germ Cell Tumor
Objective: In advanced-stage testicular cancer, postchemotherapy retroperitoneal lymph node dissection (RPLND) is performed to manage residual retroperitoneal masses. This study evaluated the histopathological features and their associations with primary tumor and clinical outcomes. Methods…
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Journal Article
Oral Findings of RASopathies in Children: Molecular Mechanisms and Clinical Spectrum with a Focus on Neurofibromatosis Type 1
RASopathies constitute a group of inherited disorders caused by germline alterations that affect the RAS– MAPK pathway, a signaling cascade essential for regulating cellular growth and development. Among these disorders, neurofibromatosis type 1 (NF1) represents the most frequently encountered…
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Journal Article
Urinary Iodine Levels and Dietary Determinants in Pregnancies Complicated by Fetal Growth Restriction, Preeclampsia, and Spontaneous Abortion
Objective: To evaluate urinary iodine levels in healthy pregnancies and in pregnancies complicated by spontaneous abortion, preeclampsia, and fetal growth restriction (FGR) and to assess the relationship between iodine status and dietary habits. Methods: This prospective cross-sectional study…
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Journal Article
Prolactin Co-Staining in Acromegaly: Clinical Features and Long-Term Outcomes
Objective: To compare the clinical presentation, tumor characteristics, surgical remission, and long-term biochemical control between patients with growth hormone (GH) and prolactin (PRL) co-staining pituitary adenomas (GH&PRL-PAs) and those with merely growth hormone–secreting pituitary adenomas…
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Journal Article
A Novel Homozygous CFH Variant Associated with Atypical Hemolytic Uremic Syndrome Triggered by Colorectal Cancer: A Case Report
Complement-mediated thrombotic microangiopathy (cmTMA), historically referred to as atypical hemolytic uremic syndrome, is driven by dysregulated alternative complement activation and is often unmasked by secondary triggers. A 40-year-old man with pre-existing hypertension (peak blood pressure…
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Journal Article
Investigation of Attitudes Toward COVID-19 Phobia and COVID-19 Vaccine in Healthcare Professionals in Türkiye
Objective: This study aimed to examine COVID-19 phobia and attitudes toward the COVID-19 vaccine among healthcare professionals. Methods: This descriptive cross-sectional study was conducted between January and March 2021. Ethical approval and Ministry of Health permissions were obtained before the…