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Turkish Journal of Internal Medicine
ISSN 2687-4245 · Nizameddin KOCA · 276 artikel di indeks
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Artikel Jurnal
Evaluation of the Systemic Immune-Inflammation Index and Hemoglobin Albumin Lymphocyte Platelet Score in Celiac Patients: A Retrospective Single-Center Study
Objective: Celiac disease (CD) is a chronic immune-mediated enteropathy diagnosed using serological tests and histopathological evaluation of duodenal biopsies according to the Marsh classification. Because biopsy is invasive, attention has shifted toward simple inflammatory biomarkers derived from…
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Artikel Jurnal
Advances in Hemophilia Therapy: From Conventional Factor Replacement Therapy, Extended Half-Life (EHL) Products to Non-Factor and Gene-Based Therapies
Objective: Hemophilia, a genetic bleeding disorder caused by deficiencies in clotting factors VIII, IX, or XI, has transitioned from a fatal disease to a chronic but manageable condition. Traditional management with plasma-derived and recombinant factor replacement improved survival and reduced…
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Retrospective Evaluation of the Glasgow‑Blatchford Score in Upper Gastrointestinal Bleeding: Impact on Inappropriate Referrals and Unnecessary Healthcare Costs
Objective: Upper gastrointestinal bleeding (UGIB) is a critical gastroenterological emergency originating from the esophagus, stomach, or duodenum that requires rapid risk stratification in the emergency department [1,2]. A substantial proportion of patients evaluated in secondary care hospitals…
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Interstitial Lung Disease–Associated Cardiac Dysfunction: Beyond Pulmonary Hypertension
Interstitial lung diseases (ILDs) are a heterogeneous group of fibrotic and inflammatory lung disorders characterized by restrictive physiology and impaired gas exchange. However, emerging evidence suggests that ILD is a multisystem disorder with significant cardiovascular involvement extending…
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Six-Month Changes in Hemogram-Derived Inflammatory Indexes and Glycemic Parameters in Patients with Type 2 Diabetes: A Real-World Retrospective Study
Objective: To evaluate six-month changes in hemogram-derived inflammatory indices (neutrophil-tolymphocyte ratio [NLR], systemic immune-inflammation index [SII], systemic inflammation response index [SIRI], and aggregate index of systemic inflammation [AISI]) and their association with glycemic…
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The Silent Long-Term Damage of Resistant Hypertension: A Clinical Case Report
Background/Aim: Resistant hypertension (RH) is a complex clinical condition associated with substantial cardiovascular and renal morbidity. Persistent blood pressure (BP) elevation despite optimal multidrug therapy should prompt a careful search for secondary causes and hypertension-mediated target…
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The Relationship Between Disease Awareness and Treatment Adherence in Patients with Diabetes: A Single-Center Study
Objective: Diabetes mellitus is a chronic metabolic disease requiring long-term lifestyle modification and medical treatment. Inadequate disease management may lead to serious acute and chronic complications, increased morbidity, and reduced quality of life. Treatment adherence in diabetes is a…
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Antibiotic-Associated Leukocytosis and Thrombocytosis: An Intriguing Paradoxical Condition
Antibiotics are indispensable for the treatment of bacterial infections. In such infections, leukocytosis and thrombocytosis are commonly observed. With appropriate antibiotic treatment, white blood cell (WBC) and platelet (PLT) counts are expected to normalize. However, rarely, antibiotic therapy…
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A Machine Learning–Based Pilot Study for the Classification of Thalassemia Subtypes Using Routine Laboratory Parameters
Objective: Thalassemia is a hereditary hemoglobinopathy and remains a significant public health problem, particularly in Mediterranean regions. Although genetic testing represents the gold standard for subtype classification, access to such testing is limited in many clinical settings. This pilot…
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Glycemic Profiles of a Nation: Findings from Türkiye’s World Diabetes Day Screening Study
Objective: To determine the prevalence of dysglycemia, including impaired glucose tolerance (IGT) and newly diagnosed diabetes mellitus (NDDM), in individuals visiting healthcare centers across Türkiye on World Diabetes Day and to assess the associated demographic and clinical risk factors.Methods…
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Serum and Urinary Netrin-1 as Biomarkers for Kidney Injury in Adults with Transfusion-Dependent Beta-Thalassemia
Objective: Kidney disease in transfusion-dependent β thalassemia (TDBT) patients is more common and is associated with prolonged patient survival. Methods: This was a case‒control study that included 44 adult patients with TDBT and evidence of kidney disease (impaired renal function…
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Artikel Jurnal
Clinical Presentation of Hypothyroidism in a Primary Care Cohort: An Exploratory Analysis of Gender Differences
Objective: To describe patient-reported symptoms of hypothyroidism in a primary care cohort and perform an exploratory assessment of potential gender differences. Methods: This retrospective observational study included 1000 patients with confirmed hypothyroidism treated at the Public Institution…
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Outcomes of Sorafenib Therapy in Radioactive Iodine-Refractory Differentiated Thyroid Cancer: A 12-Year Single-Center Experience
Objective: Differentiated thyroid cancer (DTC) generally has a favorable prognosis; however, resistance to radioactive iodine therapy (RAI) markedly worsens outcomes. Sorafenib is among the standard treatment options for RAI-refractory DTC. This study aimed to present our single-center experience…
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Obstructive Sleep Apnea and Glaucoma
The aim of the present brief comments on recent articles from the world literature that focus on the role of obstructive sleep apnea (OSA) in the development of glaucoma is to emphasize this significant association. This matter more often stands restricted to fields of neurology, pneumology, and…
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Artikel Jurnal
Artificial Intelligence in Endocrinology: ChatGPT’s Insights on Pheochromocytoma
Objective: To evaluate the role of ChatGPT, an artificial intelligence (AI) model, in enhancing medical education by providing insights into pheochromocytoma which is a rare adrenal tumor. Methods: A conversational interaction with ChatGPT was conducted, focusing on clinical aspects of…
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Two Sides of the Same Coin: Metabolic and Genetic Overlaps in Colorectal Cancer and Cardiovascular Disease
Objective: To examine the association between colorectal cancer (CRC) and cardiovascular disease (CVD), evaluating shared risk factors, treatment-related cardiac complications, and the need for multidisciplinary care approaches.Methods: This narrative review was based on a structured literature…
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Balancing Ethics, Education, and Compassion in Physician-Assisted Suicide and Euthanasia
Objective: It is 2024, and the debate of physician-assisted suicide and euthanasia remains highly complex and impactful. This discussion extends to the legal and ethical theories that affect these issues, but also profoundly impact real lives and families. Understanding where we stand today…
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Unveiling Multiple Endocrine Neoplasia Type 1 (MEN-1) in a Young Pakistani Male with Recurrent Hypoglycemia: A Diagnostic Odyssey in a Resource-Limited Setting
This case report describes a 32-year-old Pakistani male who was initially admitted to a tertiary care hospital with Typhoid fever, but later developed recurrent life-threatening hypoglycemia. Extensive investigations revealed elevated insulin and C-peptide levels, a pituitary microadenoma, and a…
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Artikel Jurnal
The Role of Inflammatory Markers in Predicting Autoimmune Comorbidities Among Patients with Type 1 Diabetes Mellitus
Background: Type 1 diabetes mellitus (T1DM) frequently coexists with other autoimmune diseases, which may enhance systemic inflammation and affect clinical outcomes. Novel inflammatory indices, including the pan-immune-inflammation value (PIV) and systemic immune-inflammation index (SII), have…
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Artikel Jurnal
Hemolysis and Vaso-Occlusive Crisis in Sickle Cell Disease: A Review
Sickle Cell Disease (SCD) is an inherited condition characterised by haemolysis and Vaso-occlusive crisis (VOC), resulting in considerable morbidity and organ impairment. These crises lead to consequences like stroke, splenic sequestration, and acute chest syndrome, significantly affecting patients…