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MedComm
Scopus
ISSN 2688-2663 · Wiley · 1,622 articles in the index
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Journal Article
State‐of‐the‐Art Strategies for Circular RNA in Cancers: Opportunity and Challenge
ABSTRACT Circular RNAs (circRNAs) are characterized by their covalently closed structure, remarkable stability, and precise spatiotemporal regulation, evolving from once‐overlooked transcriptional byproducts to pivotal molecular regulators. In addition to their well‐established function as microRNA…
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Journal Article
Accelerate the Highly Efficient Development of mRNA Vaccines Through Advanced Computational Methods
ABSTRACT mRNA medicine is an emerging therapeutic approach that utilizes messenger RNA to synthesize functional proteins directly within target cells. This technology offers notable advantages including rapid development cycles, diverse therapeutic applications, and adaptable platform design for…
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Journal Article
Unveiling a BRAF Signature Proficient in Accurately Capturing Oncogenic Activity and Guiding Prognostic Prediction Across Multiple Cancers
ABSTRACT Although BRAF is frequently mutated across multiple cancer types, its clinical utility as a prognostic biomarker has remained inconsistent in clinical practice, likely due to additional events modulating BRAF signaling pathways. This inconsistency has driven our investigation into the…
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Journal Article
Bone Metastasis: Molecular Mechanisms, Clinical Management, and Therapeutic Targets
ABSTRACT Bone metastasis (BoMet) is a common complication in various cancers. Approximately 20–30% of patients with cancer develop BoMet, which is most frequently associated with solid tumors, such as breast, prostate, and lung cancers. BoMet can lead to skeletal‐related events such as fractures…
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Journal Article
Hydrogels for Cancer Immunotherapy: Strategies From Construction to Application
ABSTRACT Cancer is a complex disease characterized by systemic dysfunction, necessitating a balance between therapeutic efficacy and safety. Immunotherapy is a core treatment approach for activating the antitumor immune response in the human body. The development of intelligent hydrogels has…
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Journal Article
Neuro‐Immune Crosstalk: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets
ABSTRACT The advent of neuroimmunology has dismantled the traditional doctrine of the brain's immune privilege, uncovering a sophisticated and dynamic bidirectional regulatory interplay between the nervous and immune systems. This review synthesizes pivotal advances in neuroimmunology, integrating…
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Journal Article
Cleavage and Polyadenylation Specificity Factor Subunit 5 Regulates Pulmonary Artery Smooth Muscle Expansion and Hypoxic Response
ABSTRACT Pulmonary hypertension (PH) is a fatal condition that affects individuals with systemic sclerosis (SSc), a multiorgan fibrotic disease with limited treatment options. A central feature of PH is vascular remodeling, defined by the narrowing of the arteriole lumen due to cell proliferation…
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Journal Article
HSD17B7 Counters Bone Loss in Estrogen Deficiency via Estrogen Receptor Stabilization and Mediates the Effect of Raloxifene
ABSTRACT Estrogen receptor (ER) α is a central regulator of osteoclasts in osteoporosis induced by estrogen deficiency. ERα is regulated through interactions with various coactivators; however, the precise mechanisms of these interactions are not yet fully understood. We screened for proteins that…
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Journal Article
Inflammation and Cancer: Molecular Mechanisms and Therapeutic Targets
ABSTRACT Inflammation is a core pathological factor regulating tumor initiation, progression, and therapeutic resistance, and elucidating its molecular crosstalk with tumors is crucial for developing effective clinical therapies. Internal drivers of inflammation–tumor transformation include genomic…
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Journal Article
Traditional Chinese Medicine Modernization in Diagnosis and Treatment: Utilizing Artificial Intelligence and Nanotechnology
ABSTRACT Traditional Chinese medicine (TCM), consisting of a complete TCM diagnosis and treatment system, is a valuable treasure in the long river of Chinese clinical history. However, the subjective diagnosis, ambiguous mechanisms, and complex formulas make it slightly lag behind the development…
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Journal Article
LungSurg: A Generative AI System for Segmentation and Phase Classification in Thoracoscopic Lobectomy
ABSTRACT The integration of artificial intelligence (AI) into surgical practices is advancing towards greater intelligence and precision. This study assesses the potential of AI in video‐assisted thoracoscopic surgery (VATS) lobectomy for lung cancer by developing an AI system named LungSurg…
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Journal Article
Genomic‐Based Epidemiological Analysis of the Post‐Pandemic Mycoplasma pneumoniae Resurgence
ABSTRACT Mycoplasma pneumoniae infections resurged globally in 2023–2024 following a significant decline during the coronavirus disease 2019 (COVID‐19) pandemic. To understand the genomic epidemiology of this resurgence in China, a nationwide 1‐year genomic surveillance identified 9907 patients…
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Journal Article
Nitrate Enhances Gastric Mucosa Defense and Repair Process in Ethanol‐Induced Gastric Ulcer Rats via the Notch–Tff2 Pathway
ABSTRACT Gastric mucosal integrity is essential for maintaining systemic homeostasis, serving as the primary defense against external insults. Ethanol ingestion is a major clinical cause of gastric mucosal injury, yet effective prevention or treatment remains limited. This study investigates the…
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Journal Article
Clinical Benefit of PD‐1/PD‐L1 Inhibitors as Standard First‐Line Treatment in Low PD‐L1‐Expressing Advanced Solid Tumors: A Systematic Review and Meta‐Analysis
ABSTRACT This study aimed to assess the benefits of immune checkpoint inhibitors (ICIs) for patients with low or negative PD‐L1 expression in advanced solid tumors. The study included cancers approved by the FDA for first‐line ICI therapy without PD‐L1 restrictions, incorporating phase III…
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Journal Article
Radiogenomics: Current Understandings and Future Perspectives
ABSTRACT Radiogenomics is a rapidly developing field that links radiological image features (radiomics) to genomic‐level data (genomics, transcriptomics, and epigenomics), addressing the limitations of single‐omic approaches. Radiomics provides a noninvasive and cost‐effective method to capture…
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Journal Article
Changes in Metabolites and Microbial Communities in Follicular Fluid Associated With Ovarian Function in Patients With Polycystic Ovary Syndrome
ABSTRACT Polycystic ovary syndrome (PCOS) is a well‐documented endocrine disorder associated with metabolic abnormalities. Research has indicated potential links between PCOS and the gut microbiome, and the presence of microbial communities in follicular fluid (FF) has been demonstrated; however…
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Journal Article
Natural Products in Cancer Prevention and Therapy: Current Challenges and Future Directions
ABSTRACT Natural products, originating from diverse biological sources, serve as a critical reservoir of bioactive compounds for cancer intervention across prevention, treatment, and supportive care. Their mechanisms extend beyond direct cytotoxicity to include modulation of tumor metabolism—such…
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Journal Article
Metabolic Dysfunction and Coronary Plaque Vulnerability: The Predictive Role of Insulin Resistance Indices in Cardiovascular Outcomes
ABSTRACT Significant residual cardiovascular risk persists in patients diagnosed with coronary artery disease despite intensive lipid‐lowering therapy. Although insulin resistance (IR) is an established epidemiological risk factor, the biological mechanisms by which it promotes plaque…
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Journal Article
The Gut Microbiota as a Mediator in the Relationship Between Dietary Patterns and Depression
ABSTRACT The interplay between diet, gut microbiota, and depressive symptoms is increasingly recognized, but underlying mechanisms remain unclear. We investigated whether adherence to several dietary patterns relates to gut microbial signatures and whether these profiles are associated with…
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