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ISSN 2688-268X · Wiley · 367 artikel di indeks
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Artikel Jurnal
Noninvasive imaging of amyloid‐beta and tau in rodent and nonhuman primate models
Abstract Neurodegenerative diseases are characterized by the aberrant accumulation of protein aggregates. The development of noninvasive imaging techniques for detecting pathological hallmarks, amyloid‐beta plaques and tau tangles in Alzheimer's disease patients has advanced significantly and has…
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Artikel Jurnal
Alterations of the oral microbiome in patients reinfected with SARS‐CoV‐2 omicron variants
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection induces perturbations in the human oral microbiome. However, alterations of the oral microbiome in patients reinfected with SARS‐CoV‐2 omicron variant (ORs) remain uncharacterized. We enrolled 2046 participants…
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Artikel Jurnal
Resveratrol attenuates areca nut extract‐induced chronic colitis by suppressing pyroptosis of intestinal epithelial cells via modulating cGAS/STING signaling
Abstract Areca nut extract (ANE) worsens chronic colitis by disrupting gut barrier integrity; however, the underlying mechanisms remain unclear. In this study, we investigate whether resveratrol (RSV) can protect against ANE‐induced colonic injury by specifically targeting intestinal epithelial…
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Artikel Jurnal
Multifunctional tumor vaccines carrying thalidomide regulate T cell exhaustion and ferroptosis for immunotherapy strategies
Abstract Significant advancements have been made in the development of therapeutic tumor vaccines for hepatocellular carcinoma (HCC) in the past decade. However, the application of this technique is restricted by the paucity of suitable vaccine adjuvant and vaccine formula that could enhance the…
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Artikel Jurnal
A new strategy of construction of porcine myocardial infarction model for preclinical research
Abstract The porcine model of myocardial infarction (MI) has been widely used to assess the feasibility, safety, and efficacy of prototype products in preclinical research. The heterogeneity of the left coronary artery (LCA) among pigs led to relatively low stability and repeatability, likely…
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Artikel Jurnal
Microfluidic single‐cell technologies for immunotherapeutic target discovery: From design concepts to preclinical applications
Abstract Immunotherapy, which modulates the patient's immune system to treat diseases, has revolutionized cancer therapy and is now being explored for autoimmune diseases. However, cellular heterogeneity in the immune system, tumor microenvironment, and inflamed tissues poses a major challenge to…
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Artikel Jurnal
Transforming acute exacerbations of chronic obstructive pulmonary disease (AECOPD) risk assessment: A multi‐algorithm machine learning approach for precise clinical phenotyping
Abstract Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) significantly impact patient outcomes and quality of life. Accurately predicting AECOPD occurrence remains essential for optimizing disease management, yet existing predictive models have notable limitations. A…
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Artikel Jurnal
Multifunctional antimicrobial peptide‐containing electrospun nanofibrous dressings for accelerating wound healing with exposed bone
Abstract The management of bone‐exposed wounds has posed a challenging dilemma in orthopedic clinical practice due to inadequate local tissue perfusion and impaired formation of granulation tissue for wound coverage after bone exposure. To address the treatment requirements of exposed bone wounds…
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Artikel Jurnal
Piezo‐type mechanosensitive cation channel 1 in bone biomechanics and its multidimensional distribution characteristics in skeletal tissue
Abstract Mechanical stress coordinates bone growth, resorption, and formation through a complex and multidimensional biological mechanism. During mechanical loading, the piezo‐type mechanosensitive cation channel 1 (PIEZO1)—the primary mechanotransducer in bone—mediates the mechanochemical…
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Application of 23Na MRI at 7 Tesla in distinguishing IDH genotype, P53 phenotype, and Ki‐67 LI in adult‐type diffuse gliomas
Abstract Background: The diagnostic performance of ultra‐high‐field 23Na magnetic resonance imaging (MRI) in predicting the P53 phenotype and Ki‐67 labeling index (LI) in adult‐type diffuse gliomas is still unknown. No studies have compared its diagnostic efficacy with diffusion weighted imaging…
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Artikel Jurnal
Integrated multi‐omics analysis reveals metabolic reprogramming as a key driver of angiotensin II‐induced vascular remodeling
Abstract Vascular remodeling is a prominent pathological characteristic of cardiovascular diseases (CVDs), with angiotensin II (Ang II) known to induce vascular injury and remodeling by modulating the functions of vascular smooth muscle cells (SMCs). However, the precise mechanisms underlying this…
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Artikel Jurnal
A multimodal deep learning framework for predicting sunitinib response in advanced clear cell renal cell carcinoma
Abstract Despite sunitinib remaining the cornerstone of systemic therapy for advanced renal cell carcinoma (RCC), reliable predictive biomarkers for therapeutic response remain elusive. We retrospectively analyzed multi‐modal data (complete across four modalities) from 157 clear cell RCC (ccRCC)…
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Artikel Jurnal
Chemical dehydration‐induced ultrafast clearing method for human tissues
Abstract Three‐dimensional (3D) visualization and analysis of histological features in human tissue can enhance our comprehension of organ function and elevate the precision of clinical diagnosis. Tissue optical clearing technique has emerged as a potent approach for achieving 3D imaging of large…
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Artikel Jurnal
Bionic nanobombs target nasopharyngeal carcinoma to enhance the efficacy of chemoradiotherapy by destroying DNA damage repair systems
Abstract Due to the concealed location of the nasopharynx, early diagnosis and treatment of nasopharyngeal carcinoma are relatively difficult. Although nasopharyngeal carcinoma is sensitive to radiation, normal tissues and organs are inevitably damaged by radiation. Patients who cannot tolerate…
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Artikel Jurnal
Protein binding assessment of immobilized nanobody using interferometric nanoporous platform
Abstract Protein sensors are key tools for infectious disease diagnosis and monitoring. The medical diagnostics field is now rapidly identifying key protein markers for the detection of a range of conditions, from early cancer development through to assessment of dementia risk a decade prior to…
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Artikel Jurnal
Potential clinical utility of small extracellular vesicles derived from head and neck tumours
Abstract The selective protein cargoes carried within small EVs create a distinctive proteome that mirrors the condition of tumour cells, making them an invaluable source of biomarkers for head and neck cancer (HNC). Liquid biopsies utilising EVs from biofluids offer a non‐invasive alternative to…
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Artikel Jurnal
PSMA PET‐directed radiotherapy for prostate cancer: From precision planning to future innovations
Abstract Positron emission tomography (PET), particularly with prostate‐specific membrane antigen (PSMA) tracers, has revolutionized the clinical management of prostate cancer (PCa). This review highlights the pivotal role of PET molecular imaging in guiding radiotherapy (RT) across diverse…
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Artikel Jurnal
Single‐cell RNA sequencing revealed the T‐cell heterogeneity and exhaustion subsets of Helicobacter pylori‐induced gastritis‐to‐cancer transformation
Abstract Gastric cancer (GC) is the third leading cause of cancer‐related deaths worldwide. Helicobacter pylori (H. pylori) infection is a crucial initiative factor for the Correa cascade occurrence of GC. However, the immunological mechanisms of H. pylori‐induced GC remain incompletely understood…
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Artikel Jurnal
Attenuation of arsenic trioxide‐induced endothelial injury: unveiling the protective role of ginkgolic acid through inhibition of TRPM4 SUMOylation: Evidence from Raman cellular imaging
Abstract Arsenic trioxide (ATO) therapy is limited by its severe vascular toxicity, which manifests as endothelial injury through mechanisms that remain poorly defined. This study identifies the SUMOylation of the Transient Receptor Potential Melastatin 4 (TRPM4) channel as a pivotal pathological…
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Artikel Jurnal
Advances in high‐resolution photoacoustic imaging techniques for cellular visualization
Abstract Photoacoustic imaging is an advanced biomedical imaging technique that combines optical excitation and ultrasound detection to provide molecular functional information of biological tissues in vivo. From the underlying principles, the spatial resolution and imaging depth of the…