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eJHaem
ISSN 2688-6146 · Wiley · 1.415 artikel di indeks
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Artikel Jurnal
Secondary Chronic Myeloid Leukemia in the Blast Phase With Mixed Phenotype After Radiation Therapy: A Case Report
ABSTRACT A 55‐year‐old woman underwent hysterectomy and pelvic radiation for cervical cancer, which remains in remission. Forty‐three months later, she developed secondary CML‐BP with CD19+ mixed phenotype (B/myeloid), previously unreported. Following induction therapy, sequential therapy with…
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Artikel Jurnal
Transition Readiness Assessment Questionnaire: A Tool Associated With Transfer Success for Adolescents and Young Adults Living With Sickle Cell Disease?
ABSTRACT Transition from pediatric to adult healthcare is a critical period for adolescents and young adults (AYA) with sickle cell disease (SCD), often associated with increased morbidity. In Canada, healthcare transfer is mandated by Age 18, yet objective measures to predict transition outcomes…
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Rosuvastatin in Combination With Bortezomib Promotes Osteogenesis in Myeloma Bone Disease by Inhibiting the Secretion of CCL3
ABSTRACT Background Myeloma bone disease (MBD) is a devastating complication of multiple myeloma (MM) and a primary cause of disability in affected patients. Its pathogenesis is driven by an imbalance in bone remodeling, largely attributed to the overexpression of C‐C motif chemokine ligand 3…
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Artikel Jurnal
Acute Myeloid Leukemia With Plasmacytoid Differentiating Cutaneous Lesions: A Case of Double Identity or Active Transformation
ABSTRACT Introduction Acute myeloid leukemia (AML) with plasmacytoid dendritic cell differentiation (pDC‐AML) is a newly described subtype of leukemia with features resembling blastic plasmacytoid dendritic cell neoplasm (BPDCN). Case Presentation Herein, we present a case of pDC‐AML in which bone…
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Artikel Jurnal
Cytogenomic Abnormalities in Children With Acute Lymphoblastic Leukemia From Western Mexico: A Single‐Center Fluorescence In Situ Hybridization‐Based Study
ABSTRACT Introduction In Mexico, the 5‐year overall survival (OS) rate for pediatric acute lymphoblastic leukemia (ALL) ranges from 45% to 85%, markedly lower than the ∼90% reported in high‐income countries, where cytogenomic testing is essential for accurate risk stratification and therapeutic…
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A Pilot Project to Evaluate the Benefit of Additional Support in Haematopoietic Cell Transplant (HCT) Research Data Management on Behalf of Anthony Nolan and BSBMTCT
ABSTRACT Background The participation of transplant centres in research studies that request detailed follow‐up data on included patients can be challenging due to the amount of time centre Data Managers have to complete additional requests. The Research Data Manager (RDM) Pilot Project was…
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Artikel Jurnal
Effect of Early Administration of Anti‐MRSA Drugs for Febrile Neutropenia in Allogeneic Hematopoietic Cell Transplantation
ABSTRACT Background In febrile neutropenia (FN), the empirical use of anti‐methicillin‐resistant Staphylococcus aureus (MRSA) drugs is recommended, particularly when mucosal damage occurs during fluoroquinolone antibiotic administration. Therefore, the early use of anti‐MRSA drugs may be…
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Artikel Jurnal
Combined Antithrombin and Heparin Supplementation to Blood for Restoring Heparin Responsiveness After Andexanet Alfa Exposure: An In Vitro Model
ABSTRACT Background: Andexanet alfa, a Gla‐domainless mutant factor Xa (GDXa), reverses oral FXa inhibitors but can cause severe heparin resistance during cardiopulmonary bypass (CPB). Antithrombin (AT) supplementation may mitigate this effect, though dosing evidence is limited. Methods We…
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Artikel Jurnal
High miR‐202‐5p Expression at Initial Diagnosis is Associated With Tyrosine Kinase Inhibitor Resistance In Chronic Myeloid Leukemia—A Result From a Nested Case‐Control Study
ABSTRACT Background Tyrosine kinase inhibitor (TKI) resistance remains a critical challenge in chronic myeloid leukemia (CML). While mechanistic studies implicate miR‐202‐5p in resistance, its clinical relevance as a biomarker at diagnosis requires validation. Methods A nested case‐control design…
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Artikel Jurnal
A Unique Case of Concomitant T‐Prolymphocytic Leukemia and B‐Cell Acute Lymphoblastic Leukemia
ABSTRACT T‐prolymphocytic leukemia (T‐PLL) is a rare lymphoid malignancy with a poor prognosis. B‐cell acute lymphoblastic leukemia (B‐ALL) also confers a poor prognosis, especially in patients with high‐risk features without an option for transplant. Here, we present a case of a patient with T‐PLL…
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Artikel Jurnal
Systemic Immune Alterations in Paediatric Classical Hodgkin Lymphoma With CCL17 and MCP‐4 as Diagnostic and Predictive Biomarkers
ABSTRACT Background Paediatric classical Hodgkin lymphoma (cHL) is the most common malignancy in adolescents, and despite excellent survival, a subset of patients experiences treatment failure or severe long‐term toxicity, underscoring the need for improved risk stratification. Early response…
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Artikel Jurnal
Venous Thromboembolism in Aggressive B‐Cell Lymphoma Patients Treated with CD19 CAR‐T Therapy: Single‐Institution Study
ABSTRACT Background Large B‐cell lymphomas (LBCLs) are a common subtype of non‐Hodgkin lymphomas. CD19 chimeric antigen receptor T‐cell (CAR‐T) therapy has revolutionized LBCL treatment, with high remission rates but also significant toxicities, including cytokine release syndrome (CRS) and immune…
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Artikel Jurnal
Clonal Evolution and Lineage Switch from T‐Cell Acute Lymphoblastic Leukemia to Acute Myeloid Leukemia in Therapy‐Resistant PICALM::MLLT10 Leukemia
ABSTRACT Background PICALM::MLLT10‐positive T‐ALL is rare and associated with poor prognosis. Lineage switch to AML is exceptionally uncommon, particularly after long‐term remission. Case Presentation We report an adolescent PICALM::MLLT10‐positive T‐ALL with a cortical thymocyte, non‐ETP…
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Artikel Jurnal
Understanding Treatment Care and Delays in Acquired Hemophilia A: A Population‐Based Study From Nova Scotia, Canada
ABSTRACT Objectives Acquired Hemophilia A (AHA) is a rare, potentially life‐threatening bleeding disorder caused by autoantibodies against factor VIII (FVIII). We aimed to characterize patients with AHA in Nova Scotia, Canada, and assess diagnostic delays. Methods We conducted a retrospective…
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Artikel Jurnal
Hemophagocytic Lymphohistiocytosis as First Manifestation of Dual B‐Cell Neoplasms: A Case Report of Co‐Existing Multiple Myeloma and B‐Cell Lymphoma
ABSTRACT Hemophagocytic lymphohistiocytosis (HLH) is an immune disorder causing excessive inflammation and tissue damage. Lymphoma, especially T‐cell lymphoma, is the most common cause of HLH, while Multiple Myeloma (MM) is rarely associated. We present a 61‐year‐old man with spiking fevers…
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Artikel Jurnal
Successful Treatment of Refractory Sweet's Syndrome With Adalimumab in a Myelodysplastic Syndrome Patient
ABSTRACT We report a 69‐year‐old man diagnosed as myelodysplastic syndrome and administrated with azacitidine and selinexor treatment. Then he was revealed high fever and multiple tender erythematous papules involving his mouth, back, upper and lower extremities, which were diagnosed as Sweet's…
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