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Stroke: Vascular and Interventional Neurology
ISSN 2694-5746 · Wolters Kluwer Health · 1,217 articles in the index
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Journal Article
Large Core Thrombectomy: Feasibility of Simplified Protocol in Resource‐Limited Settings
BACKGROUND Several trials have demonstrated the benefits of endovascular thrombectomy (EVT) for large‐core strokes (Alberta Stroke Program Early CT [Computed Tomography] Score
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Journal Article
Administering a Second Dose of Intravenous Tenecteplase in Acute Ischemic Stroke: Rationale and Design of a Pilot Clinical Trial
BACKGROUND A single dose of intravenous thrombolysis (IVT) is the only effective acute treatment for patients with ischemic stroke who do not qualify for endovascular thrombectomy. However, at least 50% of patients treated with only IVT remain disabled. Studies suggest that incomplete…
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Journal Article
Cross‐Sectional Imaging Modalities in Correlation to the Thrombolysis in Cerebral Infarction Score: The Next Frontier in Adjunctive Endovascular Stroke Therapy
The expanded Thrombolysis in Cerebral Infarction (eTICI) scale is the default method to measure reperfusion success of endovascular treatment for acute ischemic stroke. It is an estimate of the percentage of the vascular territory affected by the initial occlusion, or target downstream territory…
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Journal Article
Understanding the Relationship Between Cerebrovascular Disease and the Gut Microbiome
While traditional vascular risk factors (eg, hypertension, dyslipidemia, tobacco use) account for 20% of the explained variance in carotid atherosclerosis, they remain a prominent focus for primary and secondary ischemic stroke prevention strategies. Among other potential contributors to atheroma…
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Journal Article
Improving Measurement Accuracy of the Degree of Carotid In‐Stent Stenosis Using CT Angiography: A Comparison With DSA
Background Computed tomography angiography (CTA) tends to overestimate restenosis after cervical carotid stenting because of the substantial blooming artifacts from metallic stent materials. Hence, we propose a new measurement method to address this issue and assess the accuracy and reliability of…
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Journal Article
Redefining Ischemic Core, Penumbra, and Target Mismatch on Perfusion Imaging in Acute Anterior Distal Medium Vessel Occlusion
BACKGROUND Recent trials of endovascular thrombectomy (EVT) for acute distal medium vessel occlusions (DMVOs) were negative but also used inconsistent imaging‐based inclusion criteria, whereas many successful large vessel occlusion (LVO) EVT trials used empirically validated perfusion imaging‐based…
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Journal Article
Characterization of Barriers to Mechanical Thrombectomy Access in Georgia
BACKGROUND Similar to many low‐ and middle‐income countries, the barriers limiting wider mechanical thrombectomy (MT) access in Georgia are largely unknown. Recently, the MT access score (MTAS) was introduced as a new tool for identifying and characterizing barriers to MT access. This study aimed…
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Journal Article
POST‐UK (Adjunctive Intra‐Arterial Urokinase After Successful Endovascular Thrombectomy in Patients With Large‐Vessel Occlusion Stroke): Study Protocol of a Multicenter, Prospective, Randomized, Open‐Label, Blinded‐End Point Trial
Background Intra‐arterial infusion of an adjunctive thrombolytic agent after macrovascular recanalization by endovascular thrombectomy was regarded as a promising strategy to promote outcomes of patients with stroke. Given the characteristics of urokinase as an affordable, available, and widely…
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Journal Article
Blood Biomarkers for Large Vessel Occlusions: A Systematic Review
BACKGROUND Large vessel occlusions (LVOs), which account for approximately 25% of ischemic strokes, pose a significant challenge due to their severe impact and need for rapid diagnosis and treatment. Current diagnostic approaches—primarily based on clinical scales and imaging—often lack specificity…
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Journal Article
Natural Language Processing to Automate Cerebrovascular Event Identification in Stroke Alerts
BACKGROUND Frequent false‐positive stroke alerts can strain health resources. Machine learning models can predict stroke alert accuracy and potentially reduce this strain, but these models require time‐consuming labeling of large data sets. Weak labeling can accelerate machine learning model…
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Journal Article
Predictors and Outcomes of Hematoma Expansion and Neurological Decline in Intracerebral Hemorrhage: A Multisite Mobile Stroke Unit Study
Background Hemorrhagic stroke, particularly intracerebral hemorrhage, is one of the leading causes of permanent disability worldwide. Early hematoma expansion (HE) is a key factor in neurological deterioration (ND) and functional outcomes post intracerebral hemorrhage. This observational cohort…
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Journal Article
Optimal Coil Packing Density for Aneurysmal Complete Obliteration in Flow Diversion Stenting: A Retrospective Study
Background Flow diverter stent (FDS) deployment with coil embolization (CE) achieves high aneurysmal occlusion rates. However, no established guidelines exist for the optimal packing density (PD) when treating large or giant aneurysms. This study aimed to investigate the optimal PD in FDS…
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Journal Article
Endovascular Therapy in Patients With Acute Ischemic Stroke With Large Infarct: A Guideline From the Society of Vascular and Interventional Neurology
Background Recent randomized clinical trials of endovascular therapy in patients with large infarct provided new evidence in support of endovascular interventions in patients with acute ischemic stroke. The Society of Vascular and Interventional Neurology Guidelines and Practice Standards committee…
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Journal Article
Periprocedural Hypotension and Functional Outcomes in Ischemic Stroke Patients Undergoing Mechanical Thrombectomy
BACKGROUND There is limited information on systemic blood pressure goals and variability before and during mechanical thrombectomy and how it affects outcomes in large vessel ischemic stroke. METHODS A longitudinal cohort study of patients with acute ischemic stroke and large vessel occlusion who…
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