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Journal of Holistic Integrative Pharmacy
Scopus
ISSN 2707-3688 · KeAi Communications Co., Ltd. · 221 artikel di indeks
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Artikel Jurnal
Cannabidiol as a modulator of NLRP3 inflammasome: Mechanistic insights and therapeutic potential
Dysregulated activation of the NLRP3 inflammasome is a central driver of chronic inflammatory, neurodegenerative, metabolic, and autoimmune diseases, contributing significantly to the global burden of disease and reduced quality of life. Cannabidiol (CBD), a non-psychoactive phytocannabinoid…
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Artikel Jurnal
Gut–brain–immune crosstalk in drug-resistant epilepsy: mechanisms and therapeutic perspectives
Epilepsy is one of the most prevalent neurological disorders worldwide, affecting approximately 50–52 million individuals. Approximately 30% of patients develop drug-resistant epilepsy (DRE) despite appropriate antiseizure medications (ASMs). Conventional ASMs control neuronal hyperexcitability by…
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Artikel Jurnal
Synthesis of a novel C46 ceramide and its skin barrier repair effect verified by molecular dynamics and cellular assays
Objective: Ceramides play a critical role in skin barrier function. Here, we synthesized a novel long-chain ceramide, C46 EOP, via a sustainable catalyst-free route and elucidated its molecular mechanisms and barrier repair efficacy using an integrated computational-experimental strategy. Methods…
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Artikel Jurnal
Bibliometric analysis of research on plant exosomes/extracellular vesicles: current status, hotspots, and trends
This study performed a comprehensive bibliometric analysis on 1373 valid publications of plant exosomes/extracellular vesicles from 2010 to 2026, retrieved from CNKI, WoSCC and PubMed and screened manually. Microsoft Excel 2019 and CiteSpace 6.3. R1 were used for data analysis, including literature…
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Artikel Jurnal
Recent advances in artificial intelligence for melanoma: A review of history, models, datasets, applications, and ethical and legal considerations
Purpose: Melanoma is one of the most lethal and aggressive forms of skin cancer, often presenting as evolving pigmented lesions. This review aims to examine melanoma from a holistic perspective by evaluating integrative strategies that combine Artificial Intelligence (AI) with traditional…
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Artikel Jurnal
Antimicrobial mechanism of Artemisia argyi essential oil against Carbapenem-resistant Escherichia coli by metabolomics analysis
Objective: To investigate the antibacterial activity, mechanism of action, and wound healing-promoting effect of Artemisia argyi essential oil (AAEO) against carbapenem-resistant Escherichia coli CREO-76. Methods: The minimum inhibitory concentration (MIC) of AAEO was determined by the…
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Artikel Jurnal
Antidiabetic activity of bioactive fractions from Momordica cymbalaria Fenzl ex Naudin leaves: In vitro, in silico and in vivo evaluation
Objective: This study evaluated the antidiabetic activity of Momordica cymbalaria Fenzl ex Naudin (MC) leaf fractions, a traditionally used remedy in southern India, through comprehensive in vitro, in silico, and in vivo investigations to run scientific validation for its therapeutic potential…
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Artikel Jurnal
Influence of extraction techniques and solvent polarity on phytochemical yield: A comprehensive analytical study of Malvastrum coromandelianum (L.) Garcke
Objective: Malvastrum coromandelianum (L.) Garcke, (Family: Malvaceae) is traditionally valued for its therapeutic properties. This study aimed to evaluate the phytochemical composition and bioactivities of different plant parts and to assess the influence of extraction methods and solvent polarity…
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Artikel Jurnal
Exploring synergistic effects of bioactive compounds and pharmaceuticals in therapeutic applications
Synergy arises when the combined effect of multiple agents exceeds the sum of their individual activities. Pharmacological and bioactive chemical synergy offers a promising approach to enhance therapeutic efficacy, reduce toxicity, and overcome drug resistance. This review explores the mechanisms…
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Artikel Jurnal
Autophagy in neuropathic pain: Cell specificity, molecular mechanisms, and therapeutic prospects
Neuropathic pain (NP) is a chronic pain caused by damage or disease of the somatosensory system, with a global prevalence of 6.9%–10%. Due to the limited efficacy of current clinical treatments, there is an urgent need to explore new therapeutic targets. Autophagy, a highly conserved catabolic…
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Artikel Jurnal
Harnessing the bioactive phytocompounds and drug discovery potential of hydrophytes: A review
Water-based ecosystems have provided an ideal condition for unique and diverse group of aquatic plants to evolve with a wide range of adaptations known as hydrophytes. Such ecological niches have made them develop specialized root structures, water-dispelling surfaces, and aerenchyma, enabling them…
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Artikel Jurnal
Nimbolide as a multi-targeted phytochemical against prostate cancer therapy: Current evidence and future directions
Prostate cancer remains one of the leading causes of cancer-related morbidity and mortality among men worldwide. Despite considerable progress in early detection and androgen receptor-targeted therapies, the management of advanced and castration-resistant prostate cancer continues to present major…
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Artikel Jurnal
Machine learning models for predicting pharmacokinetics and pharmacodynamics: A step toward personalized dosing
Machine learning (ML) has become increasingly integrated within pharmacokinetics (PK) and pharmacodynamics (PD) modeling in recent years, and represents a new paradigm in precision medicine, enabling medically-relevant prediction of drug profile and drug response from data. Many conventional PK/PD…
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Artikel Jurnal
Design and optimization of polyherbal tablets for anti-inflammatory therapy: A design of experiment approach with in vitro and in vivo evaluation
Objective: To develop and optimize polyherbal tablets containing Terminalia chebula, Moringa oleifera, and Ocimum sanctum as a multi-targeted therapeutic approach for the management of chronic inflammatory disorders. Methods: Polyherbal tablets were formulated and optimized using a 32 central…
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Artikel Jurnal
Gut–brain axis in neurological disorders: mechanistic links and regulatory role of Chinese herbal medicines
The gut–brain axis (GBA) is a bidirectional communication network integrating neural, immune, endocrine, and metabolic pathways that link the gastrointestinal tract and the central nervous system. Increasing evidence implicates gut microbiota dysbiosis in the pathogenesis of neurological disorders…
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Artikel Jurnal
Mechanistic insights into the preventive efficacy of 21-day prefeeding with β-galactosidase hydrolyzed milk in DSS-induced ulcerative colitis mice
Objective: Ulcerative colitis (UC) is a chronic inflammatory bowel disease with limited preventive strategies. Here, we investigated the 21-day preventive effects of β-galactosidase hydrolyzed milk (Milk β-gal) against Dextran Sulfate Sodium (DSS)-induced UC in mice. Methods: C57BL/6 mice were…
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Artikel Jurnal
Study on the potential medical beauty efficacy screening of acetyl hexapeptide-8 and the mechanism of regulating collagen regeneration
Objective: Acetyl hexapeptide-8 (AH-8) is a synthetic polypeptide that can promote collagen regeneration; however, the underlying mechanism of this promoting effect and other potential medical beauty efficacy of AH-8 remain unknown. This study aims to explore the effect of AH-8 in promoting…
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Artikel Jurnal
From traditional herb to modern therapeutics: phytochemistry, pharmacology, toxicology, and clinical translation challenges of Cyperus rotundus L
Cyperus rotundus L. (C. rotundus.), widely distributed in tropical and temperate regions, is a perennial herb with a long history of application in traditional medical systems for treating emotional disturbances, digestive disorders, and gynecological diseases. Despite its extensive traditional…
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Artikel Jurnal
Traditional uses, chemical composition and pharmacological properties of genus Crotalaria
The plants of genus Crotalaria are widely employed in traditional folk medicine to address various ailments. Extracts from these plants have been reported to exhibit diverse pharmacological properties, including cytotoxic, antioxidant, antimicrobial, anti-trypanosomal, anti-inflammatory…