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Central Asian Journal of Medical Hypotheses and Ethics
ISSN 2708-9800 · South Kazakhstan Medical Academy · 212 artikel di indeks
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EPIGENETIC REJUVENATION THROUGH PARTIAL REPROGRAMMING: A REGENERATIVE STRATEGY FOR TISSUE REPAIR AND FUNCTIONAL RESTORATION
Over the past two decades, the field of cellular reprogramming and rejuvenation has undergone remarkable advances. Novel reprogramming modalities and technologies have been developed to improve the efficiency and safety of cellular reprogramming while expanding its potential for clinical…
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TARGETING CIRCADIAN MISALIGNMENT IN DIABETIC NEUROPATHY: A CHRONOTHERAPEUTIC FRAMEWORK FOR SCHWANN CELL PROTECTION
Introduction: Diabetic peripheral neuropathy (DPN) is a debilitating complication of type 2 diabetes mellitus (T2DM) that heavily impacts global patient quality of life and healthcare systems. Traditional management primarily centers on strict glycemic control and symptomatic pain relief…
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COLLECTIVE ACTION IS REQUIRED TO REDUCE THE BURDEN OF SPAM EMAILS IN ACADEMIA: THE CASE OF NEUROSCIENCE
Publishing the email address of corresponding authors alongside academic articles is part of an author being publicly accountable for published academic content, but also benefits both authors and potential readers. However, unscrupulous actors exploit the public availability of author email…
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IMPROVED SHORT-TERM OUTCOMES FOLLOWING OPTIMIZED ACUTE MYOCARDIAL INFARCTION CARE: A RETROSPECTIVE OBSERVATIONAL COHORT STUDY
Background: Acute myocardial infarction (AMI) remains a major cause of mortality worldwide, with outcomes strongly influenced by healthcare system organization and timely access to reperfusion therapy. Evidence from Central Asia, including Kazakhstan, remains limited, particularly regarding…
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LIFESTYLE DETERMINANTS OF ACADEMIC ACHIEVEMENT AMONG INTERNATIONAL MEDICAL STUDENTS: A CROSS-SECTIONAL ONLINE SURVEY
Introduction: International medical students are exposed to multiple stressors related to academic workload, cultural adaptation, and lifestyle changes, which may negatively influence sleep quality, psychological well-being, and academic performance. The aim of this study was to test the hypothesis…
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GLYMPHATIC RESERVE AS A DETERMINANT OF RESPONSIVENESS NEURO-METABOLIC REHABILITATION DRIVEN BY GLP-1 RECEPTOR AGONISTS: A NOVEL PARADIGM FOR MANAGING ALZHEIMER’S DISEASE AS TYPE 3 DIABETES IN CENTRAL ASIA
RIntroduction: Alzheimer’s disease (AD) and related neurodegenerative disorders represent a rapidly escalating public health crisis globally and within Central Asia, severely impacting aging populations and health system sustainability. Emerging evidence conceptualizes AD as “Type 3 Diabetes,”…
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TEN-YEAR DYNAMICS OF CHRONIC HEART FAILURE AND CONCOMITANT PATHOLOGIES: A RETROSPECTIVE OBSERVATIONAL STUDY
Introduction. Chronic heart failure (CHF) remains one of the main health problems due to the high disability of the population and frequent repeated hospitalizations. The increase in the prevalence of CHF is due to an aging population and an increase in patient survival after acute cardiovascular…
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THE ROLE OF CARDIOVASCULAR MULTIMORBIDITY IN THE DEVELOPMENT OF RISK OF RECURRENT ISCHEMIC STROKE AND ADVERSE FUNCTIONAL OUTCOMES IN ELDERLY PATIENTS
Background: Cardiovascular multimorbidity is highly prevalent in ageing populations and is a key determinant of stroke risk and long-term disability. However, data on recurrent ischemic stroke and related functional outcomes in Central Asia remain limited. Aim: To evaluate cardiovascular…
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HEALTHCARE PROFESSIONALS' EVALUATION OF HEALTH PROMOTION OFFICES AT THE PRIMARY HEALTHCARE LEVEL: A CROSS-SECTIONAL SURVEY
Introduction. Noncommunicable diseases remain one of the leading causes of morbidity, disability, and premature mortality worldwide. Strengthening health promotion and disease prevention at the primary healthcare level is considered a key strategy for reducing the burden of chronic diseases. Health…
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PREGNANCY IN INFLAMMATORY RHEUMATIC DISEASES: PATIENT AND HEALTH PROFESSIONAL PERSPECTIVES
Inflammatory rheumatic diseases disproportionately affect women of reproductive age and pose challenges from preconception to delivery. Although patient and specialist awareness in the field is growing, the evidence base for pregnancy management in this population is primarily based on…
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GLYMPHATIC RESERVE AS A DETERMINANT OF RESPONSIVENESS TO NEUROLOGICAL REHABILITATION: A HYPOTHESIS
Recovery after acquired neurological injury is highly heterogeneous. Some patients improve rapidly with standard rehabilitation, whereas others recover slowly despite comparable lesion characteristics, comorbidity profiles, and therapy. The glymphatic system supports clearance of metabolic waste…
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A SCHIZOPHRENIA HYPOTHESIS BASED ON MICROBIAL TRANSLOCATION AND ABERRANT MICROGLIAL ACTIVATION
Severe mental illness, including schizophrenia and schizophrenia-like disorders, have been associated with premature cellular senescence and gray matter volume reduction but these findings have not been adequately explored. We hypothesize that dysfunctional aryl hydrocarbon receptor, the master…
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LIFESTYLE BEHAVIORS AND SOCIO-DEMOGRAPHIC CORRELATES: AN ONLINE CROSS-SECTIONAL SURVEY
Introduction: Healthy lifestyle behaviours are essential for preventing noncommunicable diseases and improving population health. Rural populations often face disparities in access to health information and resources. This study examined the socio-demographic determinants of lifestyle behaviors…
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STEM CELL REJUVENATION: MECHANISMS, MODALITIES, AND TRANSLATIONAL CHALLENGES IN REGENERATIVE ANTI-AGING MEDICINE
The inexorable process of aging is characterised by the systemic decline of cellular function, tissue integrity, and regenerative capacity, culminating in increased susceptibility to chronic disease and frailty. While chronological aging is immutable, the biological aging process has become a…
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THYROID DYSFUNCTION AS AN UNDERESTIMATED MODIFIER OF REHABILITATION OUTCOMES IN CHRONIC DISEASES OF THE MUSCULOSKELETAL SYSTEM: A HYPOTHESIS
Introduction: Chronic musculoskeletal diseases are among the leading causes of disability worldwide. However, rehabilitation outcomes can vary significantly among patients, even when standardized therapeutic protocols are applied. Traditional rehabilitation systems often focus mainly on…
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TELERADIOLOGY AND ARTIFICIAL INTELLIGENCE IN THE DIAGNOSIS OF MUSCULOSKELETAL DISEASES: PRACTICAL RECOMMENDATIONS
Musculoskeletal disorders represent one of the most prevalent chronic disease groups worldwide. Inflammatory rheumatic diseases, particularly rheumatoid arthritis and spondyloarthritis, require early detection of structural joint damage and consistent monitoring of treatment response. Teleradiology…
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GLOBAL RESEARCH TRENDS IN DRY EYE SYNDROME PREVALENCE: A 10-YEAR WEB OF SCIENCE – BASED BIBLIOMETRIC ANALYSIS
Background. Dry eye syndrome is one of the most common ocular surface diseases, affecting patients’ quality of life and posing a significant medical and social problem. Along with growing interest in the epidemiology of this condition, global analyses of scientific trends in dry eye syndrome…
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METABOLIC REHABILITATION: INTEGRATION OF PHYSICAL MEDICINE INTO INTERDISCIPLINARY WEIGHT MANAGEMENT PROGRAMS IN CENTRAL ASIA
Introduction: Obesity and metabolic disorders represent rapidly growing public health issues worldwide and in Central Asia, with significant implications for long-term morbidity and health system sustainability. Traditional weight management strategies primarily focus on calorie restriction and…
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INTERICTAL NON-PSYCHOTIC AFFECTIVE DISORDERS IN PATIENTS WITH EPILEPSY: CLINICAL AND NEUROPHYSIOLOGICAL CORRELATES
Background: Epilepsy is commonly accompanied by psychiatric comorbidities that adversely affect clinical outcomes and quality of life. Interictal non-psychotic affective disorders remain underrecognized despite their clinical relevance and are associated with mood instability and anxiety-depressive…