209 results

From Ambiguity to Precision: Carbon Dots Bridge Traditional Charcoal Medicine and Modern Nanomedicine

Ao Zhang; Yichen Sun; Shijie Zhang et al.

BIO Integration, Vol. 7 No. 1 · 2026 · English · DOAJ Scopus

Traditional Chinese Medicine (TCM) provides rich pharmacological resources, among which charcoal medicine is a distinctive product of carbonization techniques. Renowned for its anti-inflammatory, hemostatic, and antidiarrheal properties, charcoal medicine has faced developmental limitations because…

Low-intensity Pulsed Ultrasound: A Promising Strategy for the Treatment of POI

Zenan Zhang; Chenke Kuang; Zhili Guo et al.

BIO Integration, Vol. 7 No. 1 · 2026 · English · DOAJ Scopus

Premature ovarian insufficiency (POI) is a complex endocrine disorder characterized by premature depletion of ovarian follicles, and resulting in ovarian failure and decreased fertility. Conventional hormone replacement therapy (HRT) alleviates menopausal symptoms but carries potential risks, such…

Engineering Extracellular Vesicles for Osteoarthritis Treatment: From Therapeutic Strategies-to-Clinical Translation

Jiashuo Liu; Lei Luo; Kai Feng et al.

BIO Integration, Vol. 7 No. 1 · 2026 · English · DOAJ Scopus

Extracellular vesicles (EVs) are membrane-bound nanoparticles secreted by cells and have emerged as promising therapeutic agents for osteoarthritis (OA). These vesicles exhibit high biocompatibility and the intrinsic ability to traverse physiologic barriers, delivering bioactive molecular cargo to…

Single-Cell Omics Analysis Reveals Critical Cell Subtypes and their Functional Attributes in Myocardial Ischemia-Reperfusion Injury

Wenyang Nie; Junhao Yan; Zibo Xie et al.

BIO Integration, Vol. 7 No. 1 · 2026 · English · DOAJ Scopus

Cardiac cell death and myocardial fibrosis after ischemia-reperfusion (I/R) injury are the primary causes of impaired cardiac function. Despite advances in therapies targeting ischemia, fibrosis, and angiogenesis, the early molecular and cellular mechanisms driving I/R injury remain poorly defined…

Wearable Bioelectronics: Toward Future Personal Health Monitoring

Bingyi Li; Yao Wang; Jie Mei et al.

BIO Integration, Vol. 7 No. 1 · 2026 · English · DOAJ Scopus

Soft and sustainable wearable bioelectronics are emerging as key platforms for personal health monitoring and digital healthcare. These systems can continuously acquire electrical, mechanical, and biochemical signals during daily life by integrating skin-like soft materials, hydrogel-based…

Combined Analysis of Single Cell and Spatial Transcriptome Reveals Regulation of Anti-human TREM2 Agonist Monoclonal Antibody on the Functional Status of Microglia and Identification of Key Subsets and Biomarkers

Lei Sun; Jingheng Lin; Chengcheng Song et al.

BIO Integration, Vol. 7 No. 1 · 2026 · English · DOAJ Scopus

Background: Alzheimer’s disease (AD) is a neurodegenerative disorder and the leading cause of dementia worldwide. Microglia, as central nervous system (CNS) resident macrophages, are key to AD pathology. Indeed, microglia aggregation around amyloid-β (Aβ) deposits is an AD hallmark. Triggering…

From Bench-to-Bedside: A Review of Clinical Trials in Drug Discovery and Development

Tianyang Wang; Ming Liu; Benji Peng et al.

BIO Integration, Vol. 7 No. 1 · 2026 · English · DOAJ Scopus

Clinical trials bridge basic research and clinical application, serving as essential steps in drug development. This review examines clinical trial phases (Phase I [safety assessment], Phase II [efficacy evaluation], Phase III [large-scale validation], and Phase IV [post-marketing surveillance])…

Graphene Oxide–based Biomaterials in Sports Medicine

Mengran Xi; Renwen Wan; Wei Luo et al.

BIO Integration, Vol. 7 No. 1 · 2026 · English · DOAJ Scopus

This review summarizes recent advances in the application of graphene oxide (GO) in sports medicine with an emphasis on cartilage repair, skeletal muscle regeneration, ligament and tendon repair, and tendon–bone (enthesis) healing. Owing to the distinctive physicochemical properties and favorable…

Albinism-Associated Genes and Non-Skin Cancer: Bioinformatics Analysis of Relevant miRNAs

Anita Cekani; Zoi Gkertsou; Maria Gkogko et al.

BIO Integration, Vol. 7 No. 1 · 2026 · English · DOAJ Scopus

Phytochemicals as a Promising Approach to Rheumatoid Arthritis: Current Perspectives

Vidhan Chand Bala; Asheesh Kumar Gupta

BIO Integration, Vol. 7 No. 1 · 2026 · English · DOAJ Scopus

In recent years, phytochemicals and medicinal plants have increasingly been used to treat autoimmune diseases, such as rheumatoid arthritis (RA). RA, a systemic inflammatory disease, is a chronic condition that affects primarily the joints, which are lined by synovial membranes, and leads to pain…

Combining Insulin Resistance and Renal Function to Predict Cardiovascular Events: A Multicenter Cohort Study

Ge Zhang; Tianshu Gu; Kaisaierjiang Kadier et al.

BIO Integration, Vol. 7 No. 1 · 2026 · English · DOAJ Scopus

Background: Insulin resistance (IR) and chronic kidney disease (CKD) are independent risk factors for cardiovascular disease (CVD). The triglyceride-glucose (TyG) index is recognized as a convenient marker for IR, while the estimated glomerular filtration rate based on both creatinine and cystatin…

Lactic acid and Lactylation in the Progression of Pulmonary Fibrosis

Fengxu Wang; Mengna Jiang; Li Zhu et al.

BIO Integration, Vol. 7 No. 1 · 2026 · English · DOAJ Scopus

Pulmonary fibrosis (PF) is a progressive and irreversible interstitial lung disease that is characterized by destruction of alveolar architecture, excessive proliferation of fibroblasts, and aberrant deposition of extracellular matrix (ECM) but the precise pathogenesis has yet to be fully…

From Nociception to Regeneration: Temporal Reprogramming of Sensory Neurons in Skeletal Healing

Yulong Zhang; Hao Wang; Hengguo Zhang

BIO Integration, Vol. 7 No. 1 · 2026 · English · DOAJ Scopus

Skeletal healing is constrained by a long-standing paradox. Specifically, analgesia is clinically essential, yet neural signaling is biologically required for effective repair. Recent evidence showed that bone-innervating sensory neurons are temporally plastic rather than functionally fixed. After…

Metabolic Profiles and Candidate Metabolic Features in Sanda Athletes: An Exploratory Pilot Study Comparing a Single Elite Athlete with a Non-elite Cohort

Siyan Xu; Jiahui Cheng; Zhen Chen et al.

BIO Integration, Vol. 7 No. 1 · 2026 · English · DOAJ Scopus

Objective: This study was aimed at evaluating the feasibility of using non-invasive urinary metabolomics to track individual training responses in Sanda athletes, as well as exploring characteristic metabolic signatures in a top-tier performer. Methods: Ten longitudinal biological urine samples…

A Deep Learning System for Automatic Localization of Anatomical Landmarks in X-rays to Assist in Diagnosis and Surgical Planning

Hui Zhang; Tengfei Li; Ahmad Alenezi et al.

BIO Integration, Vol. 7 No. 1 · 2026 · English · DOAJ Scopus

Background: Accurate localization of anatomical landmarks is crucial for clinical diagnosis and treatment assessment. However, existing Convolutional Neural Network (CNN)-based methods may result in global spatial information loss and consequent localization failures in the presence of complex…

Prevalence, Incidence, and Demographic Patterns of Mental Health Conditions in Prediabetes: A Real-World Cohort Study in 578,972 Adults

Faizul Hasan; Mustafa al’Absi; Muhammad Solihuddin Muhtar et al.

BIO Integration, Vol. 7 No. 1 · 2026 · English · DOAJ Scopus

Background: Prediabetes has a high prevalence worldwide; however, the prevalence of mental health conditions within the population with prediabetes is not well understood. This study was aimed at determining the prevalence and incidence of insomnia, fatigue, anxiety, and depression among a large…

Single-Cell Immune Microenvironment Atlas of Human Myocardial Infarction Focusing on Myeloid Cells and Functional Differentiation of Macrophage Subtypes

Zhenzhen Zhao; Xuheng Dou; Fu Zhao et al.

BIO Integration, Vol. 7 No. 1 · 2026 · English · DOAJ Scopus

Background: Myocardial infarction (MI) is characterized by extensive immune activation and dynamic remodeling of the cardiac microenvironment, in which myeloid cells play critical roles in regulating inflammation and tissue repair. However, the cellular heterogeneity, developmental trajectories…

Refining the Scope of BIO Integration for Focused Translational Biomedical Integration

Zhiwen Luo; Chaozong Liu; Pintong Huang et al.

BIO Integration, Vol. 7 No. 1 · 2026 · English · DOAJ Scopus

Functional Hydrogels Based on Bioactive Polysaccharides from Traditional Chinese Medicine: Advanced Biomaterial Strategies for Skin Wound Healing

Huan Wang; Jinyan Li; Wanwen Chen et al.

BIO Integration, Vol. 7 No. 1 · 2026 · English · DOAJ Scopus

Skin wound healing, especially in chronic non-healing conditions, such as diabetic foot ulcers and infected wounds, remains a formidable clinical challenge due to the complex pathophysiologic mechanisms and prolonged repair processes. Hydrogels have emerged as ideal wound dressing platforms because…

Large-Scale Chemical Space Exploration Identifies DE19725241 as a Candidate Fat Mass and Obesity-Associated Protein-Targeting Compound with Selective Activity in Pancreatic Cancer Cells

Chengjie Xu; Zhikang Cai; Donglin Wang et al.

BIO Integration, Vol. 7 No. 1 · 2026 · English · DOAJ Scopus

Background: Fat mass and obesity-associated protein (FTO), an epitranscriptomic regulator, has been implicated in cancer progression and immune regulation but the therapeutic relevance in pancreatic cancer is unclear. Methods: TCGA and GTEx transcriptomic datasets were analyzed to evaluate FTO…