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Communications Medicine
Scopus
ISSN 2730-664X · Nature Portfolio · 1.716 artikel di indeks
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Artikel Jurnal
Brain sensory network activity underlies reduced nociceptive initiated and nociplastic pain via acupuncture in fibromyalgia
Abstract Background Chronic pain may involve both nociceptive pain driven by peripheral tissue damage and nociplastic pain reflecting central nervous system dysregulation, as in fibromyalgia. Electroacupuncture has been shown to modulate these pathways, but the underlying brain mechanisms remain…
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Artikel Jurnal
Digital twins support cross-modal and cross-centric classification of mild cognitive impairment
Abstract Background Neural recordings capture crucial pathophysiological processes along the dementia continuum. However, cross-center variability in recording techniques and paradigms limit their generalizability and diagnostic power, preventing clinical use. We here propose a computational…
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Artikel Jurnal
Whole genome sequencing approach to assess homologous recombination deficiency in a pan-cancer cohort
Abstract Background Homologous recombination deficiency (HRD) impacts cancer treatment strategies, particularly effective utilization of PARP inhibitors. However, the variability of different HRD assays has hampered the selection of oncology patients who may benefit from these therapies. Our study…
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Artikel Jurnal
Early prediction of Alzheimer’s disease using longitudinal electronic health records of US military veterans
Abstract Background Early prediction of Alzheimer’s disease is important for timely intervention and treatment. We examine whether machine learning on longitudinal electronic health record notes can improve early prediction of Alzheimer’s disease. Methods From Veterans Health Administration records…
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Artikel Jurnal
Metabolism fluctuation coupling can track the progression of dementia and describe MST1 gene-related pathology
Abstract Background Cognitive resilience refers to an individual’s capacity to cope with brain aging and pathology and to delay cognitive decline, whereas existing techniques such as functional magnetic resonance imaging capture only macroscopic features without linking them to neurophysiological…
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Support for the wellbeing of frontline healthcare workers should be incorporated in health emergency preparedness planning
Abstract Health system resilience requires a resilient and well workforce. During health crises, including pandemics and outbreaks of pathogens, frontline healthcare workers can face significant challenges, resulting in personal psychosocial costs for staff members, and organisational consequences…
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Artikel Jurnal
Trans-ancestry GWAS of hot flashes reveals potent treatment target and overlap with psychiatric disorders
Abstract Background Most women experience hot flashes (hot flushes) during the menopause transition. Menopausal hot flashes typically persist for years, and for a sizeable minority of women, are substantially impairing. Genetic investigations can improve understanding of hot flash etiology. Methods…
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Artikel Jurnal
Hybrid deep learning framework MedFusionNet assists multilabel biomedical risk stratification from imaging and tabular data
Abstract Background Multi-label medical image classification is challenging due to complex inter-label dependencies, data imbalance, and the need to integrate multiple data modalities. These challenges hinder the development of robust and interpretable diagnostic systems capable of leveraging…
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Artikel Jurnal
5-methylcytosine and 5-hydroxymethylcytosine are synergistic biomarkers for early detection of colorectal cancer
Abstract Background Early cancer detection has the potential to significantly improve treatment outcomes and survival rates. This study investigates the roles of 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) as biomarkers for early-stage colorectal cancer (CRC) detection in cell-free…
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Artikel Jurnal
Transcriptomic profiling and machine learning uncover gene signatures of psoriasis endotypes and disease severity
Abstract Background Despite increased understanding of psoriasis pathogenesis, molecular classification of clinical phenotypes and disease severity is poorly defined. Knowledge gaps include whether molecular endotypes of psoriasis underlie distinct clinical phenotypes and the positive and negative…
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Artikel Jurnal
The association between childhood body size, adulthood lifestyle, and risk of 50 health conditions
Abstract Background The long-term health consequences of childhood body size and whether it can be mitigated by a healthy adult lifestyle remains unclear. This study aims to explore the associations between childhood body size and the risk of mortality and major non-communicable diseases (NCDs)…
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Natural history of simple and complex cysts in autosomal dominant polycystic kidney disease on MRI
Abstract Background Kidney volume, reflecting cumulative effects of many cysts, is an important prognostic biomarker for autosomal dominant polycystic kidney disease (ADPKD) but fails in many patients. Tracking individual cysts may more directly assess disease progression. Methods Individual cysts…
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Artikel Jurnal
Genomic epidemiology of SARS-CoV-2 in Peru from 2020 to 2024
Abstract Background: Peru recorded one of the world’s highest COVID-19 mortality rates, with nearly 4.5 million reported cases and 220,000 deaths by March 2024. Understanding the emergence and spread of SARS-CoV-2 variants in this context is key to informing effective public health responses. This…
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Non-contact lung disease classification via orthogonal frequency division multiplexing-based passive 6G integrated sensing and communication
Abstract Background The screening tools for respiratory diseases typically involve spirometry (for asthma and COPD), CT scans (for interstitial lung disease), chest X-rays (for pneumonia and tuberculosis), and sputum analysis (for tuberculosis). Methods This work examines a diagnostic approach…
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Artikel Jurnal
Wearable devices for anxiety assessment: a systematic review
Abstract Background There is growing interest in using biosignals from wearable devices to assess anxiety disorders. Among these, electrocardiography is the most widely used due to its ability to monitor cardiovascular activity. Other signals, such as respiratory, electrodermal activity, and…
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Artikel Jurnal
Global Burden of Pediatric Cardiovascular Diseases of Congenital and Non-Congenital Trends from 1992 to 2021
Abstract Background Heart diseases in children and teenagers, including congenital and non-congenital cardiovascular diseases remain major causes of illness and death worldwide. Yet, long-term patterns and recent changes are poorly understood. This study explores global trends and inequalities in…
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Artikel Jurnal
Ambient temperature and the variability between neighbouring days impacts in-patient hospitalizations in the United Kingdom
Abstract Background Acute health effects of temperature extremes and variability in temperate zones has been rarely quantified. We examine the associations of ambient temperature and temperature change between neighbouring days with all-cause and cause-specific hospitalizations. Methods Daily…
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Dose-related association between radiation exposure from computed tomography (CT) scans during trauma hospitalizations and subsequent risk of developing new-onset cancers
Abstract Background The association between radiation dose from Computed Tomography (CT) and subsequent cancer risk in adults remains poorly defined. Methods We conducted a statewide cohort study to examine the relationship between CT-related radiation exposure — measured by dose-length-product…
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