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Redox Experimental Medicine
Scopus
ISSN 2755-158X · Bioscientifica · 51 artikel di indeks
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Artikel Jurnal
Modulating redox homeostasis to counteract frailty and sarcopenia: role of exercise
Aging of skeletal muscle is characterized by a progressive loss of mass and strength, driven by structural alterations, including a reduction in fiber cross-sectional area, motoneuron degeneration, and a shift toward slower fiber phenotypes. These changes underlie sarcopenia, a major contributor to…
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Artikel Jurnal
FOXO3 involvement in neurological OxInflammation
The interplay between oxidative stress and inflammation, often referred to as OxInflammation, represents a central pathological mechanism in many neurological disorders. Within the central nervous system, this interplay involves a feedforward loop between redox imbalance and innate immune…
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Artikel Jurnal
How L-lactate mediates energetics and exercise-enhanced neuroplasticity in Parkinson’s disease
In the past decade, there have been several major paradigm shifts impacting our understanding and treatment of neurological disorders, such as Parkinson’s disease (PD). The concept of neuroplasticity in the context of a neurological disorder and aging is well accepted. As Walter Cannon stated in…
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Artikel Jurnal
Metalloflavonoid strategy: enhancing quercetin efficacy through conjugation
Quercetin, one of nature’s most potent antioxidants, exhibits a broad spectrum of biological benefits, including anti-inflammatory, anti-cancer, anti-viral, and cardioprotective properties. However, the full therapeutic potential of this natural compound is partially restricted by fundamental…
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Artikel Jurnal
NRF2 signalling in cancer-associated adipose tissue supports Warburg effect and early metabolic integration in breast cancer
Objective: Metabolic crosstalk between breast cancer cells and cancer-associated adipose tissue (CAAT), the major component of their tumour microenvironment (TME), is prerequisite for malignant phenotype. Nuclear factor erythroid 2-related factor 2 (NRF2) is a key factor in redox–metabolic…
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Artikel Jurnal
Nitrate sustains oral microbiome function and gastric NO synthesis during antiseptic use
Objective: The nitrate–nitrite–•NO pathway is a fundamental source of gastric nitric oxide (•NO), yet it is highly susceptible to disruption by antiseptic mouthwashes. This study investigated whether dietary nitrate supplementation could mitigate the functional impact of chlorhexidine (CHX)-induced…
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Artikel Jurnal
NRF2/HO-1 axis regulates fructose-induced lipid accumulation in hepatocytes
Objective: Nuclear factor erythroid 2-related factor 2 (NRF2), a key transcription factor involved in redox homeostasis, plays a critical role in preventing lipid peroxidation against various hepatic disorders, including metabolic dysfunction-associated fatty liver disease (MAFLD). Growing body of…
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Artikel Jurnal
Heme iron amplifies azoxymethane initiating effect on rat colon preneoplastic lesions
Objective: Colorectal cancer is a major public health issue for which dietary factors such as red and processed meat consumption seem to play a prominent role. Heme iron, which is present in important concentration in those food products, was reported to play a role in colorectal cancer promotion…
Juga tersedia di: DOAJ
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Artikel Jurnal
NRF2 regulation in the developing brain cortex from rat offspring exposed to intrauterine and early postnatal zinc deficits
Objective: Transcription factor NRF2, master regulator of the antioxidant response, is also involved in brain development. This paper investigated the role of NRF2 in developmental zinc deficiency-associated alterations in rat brain cortex: i) neurogenesis and ii) redox homeostasis. Methods: Rat…
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Artikel Jurnal
EFFECTS OF AGING MODULATING REDOX MEDICINE ON HEALTH AND LIFESPAN: Therapies targeting redox balance improve wound healing: a systematic review and meta-analysis
Background: Oxidative stress plays a crucial role in the pathophysiology of impaired wound healing. Indeed, it has been the focus of different therapeutic interventions, which have been explored primarily for their potential to enhance tissue repair. This systematic review and meta-analysis aimed…
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Artikel Jurnal
OXYSTEROLS AND PHYTOSTEROLS IN HUMAN PATHOPHYSIOLOGY: Adipocytes in tumour microenvironment promote chemoresistance in triple-negative breast cancer through oxysterols
Objective: Triple-negative breast cancer (TNBC) patients with excess adipose tissue experience poorer disease-free survival than those with a healthy body mass index. Adipocytes store and release cholesterol, which can be hydroxylated to form oxysterols. These cholesterol derivatives activate the…
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Artikel Jurnal
Fluorescent sensing of reactive oxygen species on the sub-cellular level
While reactive oxygen species are known to play many critical roles in health and disease, it is their sub-cellular localisation that ultimately determines their cellular impact. Small molecule fluorescent sensors have proved to be invaluable tools to study real-time changes in living cells…
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Malarial pigment-induced lipoperoxidation, inhibited motility and decreased CCR2 and TNFR1/2 expression on human monocytes
Objective: Malaria remains an important life-threatening disease that provokes a complex immune response, marked by an initial immune boost followed by long-term suppression, warranting further study. One of the manifestations of compromised immune response is co-infections, which are frequently…
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Artikel Jurnal
Targeting the bioenergetics of a resistant tumor: clinical insights into OXPHOS inhibition for cancer therapy
Although a century has passed since Otto Warburg’s discovery of the glycolytic pathway of energy production by many malignant tumors compared to normal tissues, current data cast doubt on the universality of this hypothesis. In particular, numerous recent papers suggest that in response to…
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Artikel Jurnal
Mitochondrial uncoupling proteins: redox-metabolic homeostasis and disease pathogenesis
Energy, as the main driving force of biological processes, is inextricably linked to life, which represents a continuous flow and utilization of energy. At the center of this process are mitochondria, serving as the primary source of cellular energy. An important point of mitochondrial function is…
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Artikel Jurnal
7-Ketocholesterol: occurrence, biological activities, and plausible remediation
Oxysterols, or cholesterol oxidation products, are potentially harmful derivatives of cholesterol arising from heat treatment in food systems and enzymatic as well as non-enzymatic processes in the body. Of these, 7-ketocholesterol (7KC) is a major oxysterol implicated in age-related diseases such…
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Artikel Jurnal
Anthocyanins and the browning of white adipose tissue: role of mitochondria and mechanisms of action
Obesity is defined as a chronic disease characterized by fat accumulation excess. Obesity and consumption of high-fat diets are associated with alteration in mitochondrial function and biogenesis. Changes in lifestyle and dietary habits have been shown to improve mitochondrial function. In…