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eGastroenterology
Scopus
ISSN 2766-0125 · BMJ Publishing Group · 121 articles in the index
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Journal Article
Amyloidogenic phenotypical variation affects post-transplant outcome of hereditary transthyretin amyloidosis: a retrospective study
Background Liver transplantation (LTx) was once the standard of care for hereditary transthyretin amyloidosis (ATTRv), but transthyretin (TTR) stabilising and silencing therapies have supplanted it globally, partly because these therapies work in both hereditary and wild-type ATTR, avoids surgical…
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Journal Article
High-dose taurine supplementation exacerbates alcohol-associated liver disease by inducing gut microbiota dysbiosis and bile acid dysregulation in mice
Background β-aminoethanesulfonic acid (taurine) is a conditionally essential amino acid that plays critical roles in bile acid (BA) conjugation, antioxidative defence and metabolic regulation. Previous studies showed that faecal taurine level was reduced in patients with alcohol-associated liver…
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Journal Article
Exercise and dietary interventions ameliorate MASLD via the hepatic PPARγ-miR-802-Psmd2 axis
Background MicroRNAs critically regulate metabolic dysfunction-associated steatotic liver disease (MASLD) progression and intervention. Lifestyle modifications, particularly exercise and time-restricted feeding (TRF), emerge as effective non-pharmacological strategies.Methods MiR-802 expression was…
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Journal Article
Dysosmobacter: from a serendipitous discovery to a next-generation beneficial gut commensal linked to health
Dysosmobacter is a genus of strictly anaerobic, butyrate-producing bacteria of the family Oscillospiraceae that was first described in 2020 with the human faecal type species Dysosmobacter welbionis J115T. The organism was recovered by chance during a targeted attempt to isolate new Subdoligranulum…
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Journal Article
Mechanosensitive ion channels in intestinal homeostasis and disease
Mechanical deformation is integral to intestinal physiology, linking luminal transit to epithelial adaptation and motor control. These physical cues engage multiple mechanotransduction pathways that coordinate cellular adaptation and help preserve intestinal homeostasis. Inflammation, obstruction…
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Journal Article
Plasma cell-CD8+ T cell co-enrichment distinguishes immunotherapy-responsive hepatocellular carcinoma subtypes
Background Hepatocellular carcinoma (HCC) is characterised by significant racial disparities in incidence and outcomes, yet whether these reflect distinct tumour biology or differential distribution of molecular subtypes among immunotherapy patients remains unclear.Methods We characterised…
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Journal Article
Global and regional burden of colorectal cancer potentially related to Helicobacter pylori exposure: a risk attribution modelling study
Background Emerging epidemiological and mechanistic studies suggest that Helicobacter pylori (H. pylori) exposure may be associated with colorectal cancer (CRC); however, the findings remain controversial. We aim to quantify the CRC burden potentially related to H. pylori exposure, with the…
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Journal Article
Immune cell remodelling and the peribiliary immune niche in primary biliary cholangitis: from initiation to chronicity
Primary biliary cholangitis (PBC) is a chronic autoimmune cholestatic liver disease characterised by immune-mediated destruction of small intrahepatic bile ducts. Although ursodeoxycholic acid remains the standard first-line therapy and peroxisome proliferator-activated receptor agonists have…
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Journal Article
Ultra-low-pass whole-genome sequencing of bile cfDNA in patients with biliary strictures
Background Accurate discrimination of malignant versus benign biliary strictures remains clinically challenging. We previously showed that targeted bile cell-free DNA (cfDNA) mutation analysis (Bilemut assay) enables sensitive detection of malignancy, but it does not distinguish cholangiocarcinoma…
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Journal Article
TERT rs10069690 variant is linked to reduced cholangiocarcinoma incidence but adverse prognosis in patients undergoing resection
Background Cholangiocarcinoma (CCA) is a rare cancer, with limited understanding of genetic and prognostic determinants. We aimed to explore genetic risk factors, assess their prognostic implications and evaluate associated systemic and intratumoral features.Methods We screened the UK Biobank to…
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Journal Article
Intestinal neutral ceramidase exacerbates MASH pathogenesis
Background Metabolic dysfunction-associated steatotic liver disease and its more severe manifestation, metabolic dysfunction-associated steatohepatitis (MASH), are intimately linked to genetic factors, gut microbiota and barrier alteration. Ceramidases and ceramides are associated with MASH, yet…
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Journal Article
Unified platform for multiplex immunofluorescence across liver tissues and engineered models
Background Multiplex immunostaining combined with digital image analysis has become a central tool in hepatology research because it allows for the simultaneous visualisation and spatial mapping of multiple cellular markers within a single tissue section, providing critical insights into the…
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Journal Article
Burden of metabolic dysfunction-associated steatotic liver disease in the Asia-Pacific region from 1990 to 2023
Background Metabolic dysfunction-associated steatotic liver disease (MASLD) is an increasing health problem in the Asia-Pacific region, contributing significantly to morbidity and healthcare burden. This study provides a comprehensive analysis of the burden of MASLD across countries and territories…
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Journal Article
Phosphoinositide kinase PIKfyve inhibitor apilimod blocks hepatitis E virus infection
Background Hepatitis E virus (HEV) is a leading cause of viral hepatitis, yet treatment remains limited to the off-label use of ribavirin, which can have significant side effects and is not suitable for all patients, highlighting the need for new antiviral strategies. HEV infection depends on…