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Clinical and Translational Discovery
Scopus
ISSN 2768-0622 · Wiley · 474 artikel di indeks
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Artikel Jurnal
Tumour hepcidin levels as a biomarker for predicting response to immune checkpoint inhibition in advanced non‐small cell lung cancer
Abstract Background Hepcidin, a key regulator of iron homeostasis, is often overexpressed in non‐small cell lung cancer (NSCLC). While hepcidin renders cells susceptible to ferroptosis, which is linked to the activity of programmed cell death 1 (PD‐1)/programmed death ligand 1 (PD‐L1) inhibitors…
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Artikel Jurnal
Single‐cell sequencing for cancer precision medicine: From mechanism discovery to diagnosis and therapeutics
Abstract Tumour heterogeneity, encompassing genetic, epigenetic, and microenvironmental diversity, remains a fundamental obstacle in precision oncology. Traditional bulk sequencing captures only averaged molecular profiles, thereby masking rare yet functionally critical subpopulations that drive…
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Artikel Jurnal
The emerging role of CAMK1D in diabetes, metabolism and feeding behaviours: A mechanistic systematic review
Abstract Background Diabetes, metabolic disorders and feeding behaviours continue to pose significant public health challenges. Calcium/calmodulin‐dependent protein kinase ID (CAMK1D) has recently emerged as a pivotal molecule potentially bridging peripheral metabolic control with central appetite…
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Artikel Jurnal
GPR183‐mediated activation of PI3K is a potential biomarker for immunotherapy in lung cancer
Abstract Background As one of commonly used immune checkpoint inhibition therapies, PD1 monoclonal antibodies exhibit a promising cancer immunotherapy approach. However, their efficacy on tumour immunity needs to be augment, as large numbers of patients poorly respond to the treatment or suffer…
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Artikel Jurnal
High expression of miR5700 in atypical type A thymoma and its role in promoting tumour progression
Abstract Objective Relapse and lung metastasis of atypical type A thymoma are knotty problems in clinical treatment. The identification of specific biomarkers and novel therapeutic targets is critical for advancing the precision and efficacy of interventions against this disease. MicroRNAs…
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Artikel Jurnal
CEACAM6 silencing suppresses tumour growth and sensitises cholangiocarcinoma to cisplatin
Abstract Background The CEACAM family, a major subgroup of the carcinoembryonic antigen (CEA) family, is widely expressed in normal and neoplastic tissues. Although CEACAM6 overexpression has been reported in cholangiocarcinoma (CCA), the molecular mechanisms by which it modulates chemosensitivity…
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Artikel Jurnal
Overcoming challenges in CAR‐T therapy for malignancies: Mechanisms and strategies
Abstract Background Chimeric Antigen Receptor T‐cell (CAR‐T) therapy has evolved from its initial application in hematological cancers to treating solid tumors and autoimmune diseases. Despite iterative advancements in CAR design improving efficacy and safety, challenges including limited…
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Artikel Jurnal
Toward precision oncology: An integrative multi‐omics approach for prognosis prediction and inferred immunotherapy responsiveness in breast cancer
Abstract Breast cancer heterogeneity is still a primary concern, with a large variation in the prognosis necessitating the development of personalised treatment plans. Single biomarkers can't fully encompass the breast cancer complexity and variations, and therefore, multi‐omics approaches offer a…
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Artikel Jurnal
Gut microbiota and central nervous system's direct bidirectional regulation: The mechanisms of the gut–brain axis in irritable bowel syndrome
Abstract Background Irritable bowel syndrome (IBS) is a prevalent condition in which disrupted communication between the gut and the brain plays a central role in disease manifestation. A dynamic, bidirectional regulatory network links the gut microbiota with the central nervous system (CNS)…
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Artikel Jurnal
Surufatinib plus anti‐PD‐1/PD‐L1 antibody as second‐line therapy for advanced biliary tract cancer: A single‐centre investigator‐initiated trial
Abstract Objective To explore the efficacy and safety of surufatinib in combination with anti‐PD‐1/PD‐L1 antibodies (with or without chemotherapy) in patients with advanced BTC after failure of first‐line treatment. Methods 24 patients with advanced BTC who failed first‐line treatment were admitted…
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Artikel Jurnal
Towards a digital cancer cell twin: External pharmacological validation of a mechanistic A549 electrophysiology model
Abstract Computational electrophysiology models are beginning to emerge as digital‐twin–oriented representations of cancer cells, offering mechanistic insights that complement traditional patch‐clamp experiments. In this study, we evaluate the ability of the earliest in‐silico cancer…
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Artikel Jurnal
Effect of osteopathic manipulative treatment on circulating cytokines: A pilot study in healthy adults
Abstract Background This pilot study sought to characterise changes in inflammatory cytokine levels over time within healthy subjects following one session of osteopathic manipulative treatment (OMT) focused on lymphatic drainage. Methods Healthy adult participants were recruited from the campus…
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Artikel Jurnal
Causal association and mechanistic validation of the USP8‐DLK1 axis in osteoarthritis: A genetic meta‐analysis integrated with in vitro and in vivo investigations
Abstract Background/Objective Osteoarthritis (OA) affects more than 500 million people globally and remains without effective disease‐modifying therapy, owing in part to an incomplete understanding of the molecular mechanisms driving chondrocyte degeneration. Although genetic studies have…
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Artikel Jurnal
Advancing gambogic acid for translational oncology: Redox–proteostasis collapse, multidrug resistance reversal, nanodelivery and biomarker‐guided development
Abstract Background Gambogic acid (GA), a caged xanthone derived primarily from Garcinia hanburyi, has shown broad anticancer activity across multiple preclinical tumour models. This narrative review critically evaluates the molecular mechanisms, pharmacokinetics, multidrug resistance‐modulating…
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Artikel Jurnal
The metabolic‐immune hub: Dual roles of indoleamine 2,3‐dioxygenase in the acute kidney injury‐to‐chronic kidney disease transition and therapeutic perspectives
Abstract The transition from acute kidney injury (AKI) to chronic kidney disease (CKD) represents a critical determinant of long‐term prognosis, yet the underlying immunometabolic mechanisms remain incompletely defined. Indoleamine 2,3‐dioxygenase (IDO), the rate‐limiting enzyme of the kynurenine…
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Artikel Jurnal
Utility of blood‐based Mycobacterium tuberculosis antigen‐specific host biomarkers in differentiating between spinal tuberculosis and mechanical back pain: A proof‐of‐concept study
Abstract Background Spinal tuberculosis (TB) is a potentially severe form of musculoskeletal TB. Early diagnosis of the disease is challenging due to variable and non‐specific initial symptoms. We aimed to evaluate Mycobacterium tuberculosis antigen‐specific host blood protein biomarkers that are…