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Frontiers in Bioscience-Landmark
Scopus
ISSN 2768-6701 · IMR Press · 2.024 artikel di indeks
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Artikel Jurnal
Turmeric-Derived Exosome-Like Nanoparticles Inhibit Non-Small Cell Lung Cancer via Epigenetic Regulation
Background: Turmeric-derived exosome-like nanoparticles (TELNs) are nanoscale vesicles of plant origin with therapeutic potential. However, the specific efficacy and mechanisms of TELNs in inhibiting non-small cell lung cancer (NSCLC) remain unclear. This study investigated the effects of TELNs on…
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Artikel Jurnal
TGF-β/RhoA/ROCK Signaling Activation Orchestrates Ciliary Body EMT and Fibrosis in Myopia
Background: Dysregulation of the transforming growth factor (TGF)-β/Ras homolog family member A (RhoA)/Rho-associated protein kinase (ROCK) pathway can lead to fibrotic changes in ocular diseases. The present study investigated its role in epithelial–mesenchymal transition (EMT) and fibrosis in the…
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Artikel Jurnal
Multimodal Enhancement of Colonic Motility by Acupuncture at ST36 is Mediated by TRPV1+ Cutaneous Sensory Fibers
Background: Acupuncture has been shown to promote gastrointestinal motility. This study explores whether cutaneous transient receptor potential vanilloid 1 (TRPV1)+ fibers at Zusanli (ST36) acupoint can mediate the multimodal effects of acupuncture on colorectal motility, as well as examining their…
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Artikel Jurnal
Wnt/β-catenin Pathway in Cardiac Hypertrophy and Arrhythmia: From Molecular Mechanisms to Therapeutic Opportunities
The wingless-int1/β-catenin (Wnt/β-catenin) signaling pathway plays a key role in left ventricular hypertrophy (LVH) and arrhythmias, which significantly contribute to global morbidity and mortality. Activation of Wnt/β-catenin signaling induces oxidative stress in cardiomyocytes by regulating…
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Artikel Jurnal
Hedgehog Signaling in Tongue Muscle Development: A Comparative Perspective With Limb Myogenesis
The mammalian tongue is an intricate skeletal muscle organ. From its initial formation to maturation, tongue muscle development involves precisely coordinated processes during embryonic and fetal phases of myogenesis. Extensive research on the regulatory pathways involved in tongue epithelial taste…
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Artikel Jurnal
Rho GTPase and Rho Kinase Signaling in Tissue Contractility and Intraocular Pressure Regulation
The Rho GTPase and Rho kinase (ROCK) signaling pathway is essential for cellular mechanics, acting as key regulators of the actin cytoskeleton and actomyosin contractility in various cell types and tissues. Rho GTPases, functioning as molecular switches, and ROCKs, their primary downstream…
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Artikel Jurnal
The Fundamental Mechanism of Transcranial Electrical Stimulation in Post-Stroke Rehabilitation
Stroke is a leading cause of long-term disability, and many patients fail to achieve complete recovery following cerebral injury. Therefore, post-stroke rehabilitation is essential to restore impaired function. Transcranial electrical stimulation (tES), transcranial direct current stimulation…
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Artikel Jurnal
Mechanisms of Bellidifolin in Treating Doxorubicin-Induced Cardiotoxicity: Network Pharmacology, Molecular Docking, and Experimental Verification
Background: This study aims to examine the roles and mechanisms of action of bellidifolin (BEL) in alleviating doxorubicin-mediated cardiotoxicity using network pharmacology and experimental validation . Materials and Methods: Mice with doxorubicin-induced cardiotoxicity were randomly assigned to…
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Artikel Jurnal
Epigenetic Mechanisms of Reproductive Dysfunction Induced by Endocrine-Disrupting Chemicals: Evidence From Molecular Studies
Endocrine-disrupting chemicals (EDCs), including bisphenol A (BPA), phthalates, organochlorine pesticides, and heavy metal ions, pose serious threats to reproductive health by interfering with hormonal balance and molecular signaling pathways. Recent research had expanded our understanding of these…
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Artikel Jurnal
Integrin Signaling and ECM Proteins in hPSC Maintenance and Differentiation
Integrin signaling serves as a fundamental regulator in human pluripotent stem cell (hPSC) biology, mediating adhesion, survival, and pluripotency through interactions with extracellular matrix (ECM) components. Specific integrins, including α6β1, αvβ5, and α3β1, engage ECM ligands such as…
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Artikel Jurnal
Influence of Oxidative Stress-Mediated Inflammation on the Pathogenesis of Reproductive Disorders: Exploring the Benefits of Carnosine for Prevention and Treatment of Endometriosis
Endometriosis is a chronic pathological condition characterized by the growth of endometrial-like tissue outside the uterine cavity and is frequently associated with severe pain, persistent inflammation, and fibrosis within the pelvic region and other parts of the body. The exact causes of…
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Artikel Jurnal
Neuroprotective Effects of the SIRT3/AMPK Axis in Experimental Glaucoma
Background: Glaucoma is a major cause of irreversible blindness, characterized by the progressive degeneration of retinal ganglion cells (RGCs), with oxidative stress and apoptosis playing central roles in its pathogenesis. Sirtuin 3 (SIRT3) has demonstrated antioxidant and anti-apoptotic effects…
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Artikel Jurnal
Unraveling the Interplay of D-2-HG in Glioblastoma Tumorigenesis via Integrated Machine Learning and Molecular Docking Analysis
Background: Glioblastoma (GBM) is an exceptionally aggressive type of brain tumor with a poor prognosis, underscoring the urgent need to identify new molecular targets for therapeutic development. The objective of this research is to clarify the molecular interactions affected by the oncometabolite…
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Artikel Jurnal
Exploring the Molecular Mechanisms and Shared Genetic Characteristics of Monoclonal Gammopathy of Undetermined Significance and Multiple Myeloma
Background: Monoclonal gammopathy of undetermined significance (MGUS) is a precursor to multiple myeloma (MM), but the mechanisms of progression remain unclear. Methods and Objectives: Transcriptomic datasets procured from the Gene Expression Omnibus (GEO) underwent thorough analysis to ascertain…
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Artikel Jurnal
Autism Pathoetiology and Pathophysiology: Roles of STAT3 and NF-κB Dimer Interactions in Regulating the Mitochondrial Melatonergic Pathway in Placental, CNS, and Systemic Cells
People with autism spectrum disorders (ASD) show a relative suppression of the melatonergic pathway across CNS and systemic cells. The differential regulation of the mitochondrial melatonergic pathway may therefore be an important core aspect of ASD pathophysiology in all its manifestations. Recent…
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Artikel Jurnal
Akkermansia muciniphila Ameliorates Chronic Sleep Deprivation-Induced Glucose Intolerance and Inflammatory Cytokine Activation
Objective: Emerging evidence indicates that Akkermansia muciniphila (A. muciniphila or AKK) regulates host glucose metabolism through multiple pathways. In this study, we examined the therapeutic effects of A. muciniphila on chronic sleep deprivation (CSD)-induced glucose dysregulation and the…
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Artikel Jurnal
Integrated Single-Cell and Bulk RNA Sequencing Identifies SERPING1 as a Biomarker of Immune Infiltration and Prognosis in Triple-Negative Breast Cancer
Background: Triple-negative breast cancer (TNBC) is an aggressive malignancy that lacks effective treatment. Immune infiltration plays an important role in anti-tumor responses. Serpin family G1 (SERPING1), a biomarker associated with immune infiltration, has been implicated in multiple cancers…
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Artikel Jurnal
DT-m6A: A DenseNet–Transformer Hybrid Framework for Accurate Prediction of m6A Modification Sites across Diverse Cell Lines and Tissues
Background: N6-methyladenosine (m6A) RNA methylation is a crucial epigenetic modification that plays an essential role in regulating diverse biological processes. Accurate identification of m6A sites is therefore fundamental to understanding its regulatory mechanisms. In this study, we proposed…
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Artikel Jurnal
Exploring the Potential Role of Interleukin-33 in Inducing Eosinophil-Mediated Fibrosis in Hepatic Alveolar Echinococcosis
Background: Alveolar echinococcosis (AE) is a serious zoonotic parasitic disease. This study aimed to investigate the mechanisms underlying the formation of the dense fibrotic band surrounding hepatic alveolar echinococcosis (HAE) lesions, which impedes chemotherapeutic drug penetration…
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Artikel Jurnal
Berberine Alleviates Lipopolysaccharide-Induced Acute Lung Injury by Modulating the AMPK-HMGB1-NF-κB Signaling Axis
Background: The activation of adenosine-monophosphate-activated protein kinase (AMPK) by berberine (BBR) benefits various inflammatory diseases. Conversely, high mobility group box-1 (HMGB1), a prototypical damage-associated molecular pattern (DAMP), typically exerts opposing effects. This research…
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