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MedComm – Biomaterials and Applications
Scopus
ISSN 2769-643X · Wiley · 148 artikel di indeks
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Artikel Jurnal
Nanomaterial‐Mediated Radiotherapy–Immunotherapy Combinations: Breaking Immunosuppression and Revolutionizing Cancer Treatment
ABSTRACT Malignant tumors remain a leading cause of global mortality. Radiotherapy (RT) and immunotherapy are established cornerstone therapies for most solid cancers. Their combination, radio‐immunotherapy (IRT), has demonstrated robust synergistic antitumor activity in preclinical models and…
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3D‐Printed Biomedical Materials for Personalized Medicine: Materials, Manufacturing Strategies, Translational Applications, and Future Perspectives
ABSTRACT Personalized medical treatment aims to tailor diagnosis and treatment plans to individual patients, accounting for differences in anatomical structure, gene expression, and lesion microenvironment. Traditional mold‐based manufacturing methods can hardly produce implants that perfectly…
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Rational Synthesis of MOF‐Derived Selenium Vacancy‐Rich Hollow CoNiSe2‐x Triangular Nanosheet Arrays on Carbon Cloth for Non‐Enzymatic Glucose Sensing
ABSTRACT Rational structural and defect engineering of self‐supporting electrodes is highly desirable for developing high‐performance non‐enzymatic glucose sensors. Herein, selenium vacancy‐rich hollow CoNiSe2‐x triangular nanosheet arrays were directly constructed on carbon cloth through a…
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Stromal Cell‐Derived Factor‐1α (SDF‐1α)‐Gene Activated Scaffold and Angiogenesis Process in Tissue Engineering: A Systematic Review and Meta‐Analysis of in Vitro Studies
ABSTRACT Stromal cell‐derived factor‐1α (SDF‐1α) is a potent stem cell recruitment chemokine that can promote angiogenesis, particularly when delivered via gene‐activated scaffolds (GAS). This systematic review and meta‐analysis synthesized in vitro evidence on the angiogenic potential of SDF‐1α…
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Artikel Jurnal
Advances in Organic Aggregates for Biomedical Phototheranostics
ABSTRACT Organic aggregates are emerging as versatile platforms for biomedical phototheranostics, as aggregation provides a direct means to regulate excited‐state behavior beyond the limits of isolated chromophores. Whereas conventional organic dyes often undergo aggregation‐caused quenching…
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Improving Proteolysis‐Targeting Chimera Delivery by Targeting Key Biomarkers in Tumor Endocytosis Pathways
ABSTRACT Proteolysis‐targeting chimeras (PROTACs) are promising therapeutic agents for targeted protein degradation via the ubiquitin‐proteasome system; however, their clinical application is severely constrained by poor membrane permeability due to high molecular weight and polar surface area…
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Dual‐Drug‐Loaded Liposomes: Design Strategies, Mechanistic Insights, and Therapeutic Applications in Cancer
ABSTRACT Liposomal nanocarriers are clinically established platforms for targeted drug delivery due to their biocompatibility and ability to encapsulate both hydrophilic and hydrophobic agents. However, conventional single‐drug liposomes are limited by suboptimal efficacy, systemic toxicity, and…
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Artikel Jurnal
Smart Design: Integrating Artificial Intelligence and Gene Editing for Advanced mRNA Therapeutics
ABSTRACT Artificial intelligence (AI) and gene editing are increasingly being applied to the design and evaluation of mRNA therapeutics. Although mRNA‐based medicines have achieved clear clinical impact in vaccination, broader applications remain limited by mRNA instability, delivery barriers…
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Sustained Release and Therapeutic Evaluation of Simvastatin‐Loaded Bioglass–Chitosan Gel Formulation for Skin Regeneration and Wound Healing Potential
ABSTRACT Chronic wounds pose a major clinical challenge due to a complex pathophysiological condition. It is characterized by persistent inflammation, excessive oxidative stress, and a high risk of bacterial infection, which hinders tissue repair. To address this, a multifunctional hydrogel…
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Artikel Jurnal
Barnacle‐Inspired Water‐Displacing Injectable Adhesive for Rapid Hemostasis and Antibacterial Sealing in Wet Environments
ABSTRACT Uncontrolled bleeding in wet or actively hemorrhaging environments remains a major clinical challenge in trauma management and surgical procedures. Conventional hemostatic agents and tissue adhesives often exhibit insufficient adhesion strength and delayed coagulation upon contact with…
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Translational Pathways for Smart and Bioactive Dental Biomaterials: Biocompatibility Standards, Sterilisation, Sustainability and Regulation
ABSTRACT Smart and bioactive dental biomaterials aim to deliver functional and therapeutic effects in the oral cavity; clinical uptake requires translation from laboratory performance to safe, durable and regulated use. This review synthesises translational requirements for advanced dental and…
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Myogenic Differentiation on 3D‐Printed Interpenetrating Bioactive Hydrogel of Decellularised Human Placenta With Fish Scale Gelatin
ABSTRACT Tissue‐specific templates are essential for muscle differentiation as they enhance cell alignment and regeneration. Advancements in extrusion 3D printing with biomaterial inks enable customizable designs and tailored spatial arrangements. Key growth factors and extracellular matrix (ECM)…
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Chlorine‐Functionalized Nano‐Hydroxyapatite Coatings Enhance Osseointegration in Immediate Implantation by Modulating Host–Bacteria Competition
ABSTRACT Immediate implantation integrates three surgical procedures into one and shortens the treatment cycle, showing great clinical value. However, in patients with periodontitis, the high risk of infection remains a major challenge. A critical failure factor lies in the first 24 h after…
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Exploring the Key Role of Nanotechnology on Intratumoral Microbiome Modulation for Cancer Immunotherapy
ABSTRACT The intratumoral microbiome has emerged as a critical component of the tumor microenvironment (TME), playing a significant role in tumorigenesis, pathological classification, metastasis, and prognosis. The nutrient‐rich, hypoxic, acidic, and immunosuppressive nature of the TME facilitates…
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Targeting Delivery of Cyanidin‐Loaded With Ti3C2 Nanosheets for Alleviating Vascular Calcification in Chronic Kidney Disease
ABSTRACT Vascular calcification is highly associated with cardiovascular morbidity and mortality among patients with chronic kidney disease (CKD). Despite its clinical severity, no effective therapies exist to halt its progression. Sirtuin 6 (SIRT6) has recently emerged as a promising therapeutic…
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Artikel Jurnal
Extracellular Vesicles‐Functionalized Biomaterials for Oral Disease Theragnostics
ABSTRACT Oral diseases impair oral function and are closely linked to various systemic conditions. Current clinical diagnosis and treatment modalities remain constrained by inherent limitations, necessitating innovative therapeutic strategies. Extracellular vesicles (EVs) have emerged as promising…
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Artikel Jurnal
Preparation and Biological Properties of Estradiol‐Cyclodextrin‐Polydopamine Functional Coating on Polypropylene Mesh Surface
ABSTRACT Polypropylene (PP) biological meshes are the most widely used implantable materials for the clinical treatment of pelvic organ prolapse (POP). To address the inflammation and impaired tissue repair associated with mesh implantation, as well as to compensate for estrogen deficiency in…