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mLife
Scopus
ISSN 2770-100X · Wiley · 237 artikel di indeks
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Artikel Jurnal
Distinct actomyosin–septin coordination governs conidiation and septation in Verticillium dahliae
Abstract Conidiation is the primary mode of reproduction in filamentous fungi and is essential for the dispersal of pathogenic species. However, the fundamental cellular mechanisms regulating conidiation in plant pathogenic fungi remain largely unexplored. Here, using Verticillium dahliae as a…
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Artikel Jurnal
Antibiotic resistance mediated by site‐specific mutations in the multidrug efflux transporter CmeB of zoonotic pathogen Campylobacter
Abstract The resistance‒nodulation‒division (RND) family of multidrug efflux transporters is widely distributed in Gram‐negative bacteria. Although their roles in mediating antibiotic resistance have been well known, our understanding of how they are altered to augment bacterial adaptation to…
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Artikel Jurnal
Prokaryotic defense systems: Diversity and evolutionary adaptation
Abstract Bacteriophages and archaeal viruses are the most abundant biological entities on Earth. Through a long‐standing co‐evolutionary arms race, they have driven the emergence of a diverse repertoire of prokaryotic defense systems. This review summarizes these systems, highlighting their diverse…
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Artikel Jurnal
Structures and mechanism of E2‐CBASS anti‐phage system
Abstract Bacteria deploy diverse innate immune systems to combat bacteriophage infections. The cyclic‐oligonucleotide‐based anti‐phage signaling system (CBASS) is a type of innate prokaryotic immune system. CBASS synthesizes cyclic‐oligonucleotide through cGAS/DncV‐like nucleotidyltransferases…
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Artikel Jurnal
CRISPR‐based genome editing reveals the roles of efflux pumps in Mycobacterium abscessus
Abstract Mycobacterium abscessus, one of the most antimicrobial‐resistant bacteria, is increasingly recognized as the cause of infections that are difficult to treat. Novel genetic manipulation tools are required to elucidate the biology, pathogenesis, and antibiotic resistance mechanisms of M…
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Artikel Jurnal
Profiling the host defense responses against Candida auris in a reliable Drosophila melanogaster infection model
Abstract The “superbug” Candida auris has been ranked as a priority fungal pathogen and is becoming a serious threat to public health. However, the underlying mechanisms of real‐world pathogen–host interactions remain elusive, in part due to the lack of powerful immunocompetent animal models. Here…
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Artikel Jurnal
Exploring microorganism–host interactions: Emerging organoid models and analytical approaches
Abstract Microorganisms play a vital role in human health through their interactions with the body. Studies of host–microbe mechanisms and interactions are crucial for advancing health management. Recently, the organoid‐based models have provided new platforms in this field. Derived from human…
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Artikel Jurnal
A hot origin of dissimilatory sulfite reduction catalyzed by DsrAB in the Paleoarchean Era
Abstract Dissimilatory sulfite reduction (DSR) has been essential to microbial energy metabolism in the biogeochemical sulfur cycle since the Paleoarchean Era. However, due to the lack of an integrated assessment of geological record and genomic data, the evolutionary origin of DSR remains elusive…
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Artikel Jurnal
Coxiella burnetii inhibits host cell death by ubiquitination‐induced inactivation of an apoptosis nuclease
Abstract Coxiella burnetii modulates a variety of host cell processes to create a niche permissive for its intracellular replication using effectors injected by its Dot/Icm type IV secretion system. More than 130 such effectors have been identified, but the function of most of them remains unknown…
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Artikel Jurnal
Elucidating the physiological significance of iodate reduction in Shewanella species
Abstract The reduction of iodate by Shewanella species plays a crucial role in iodine biogeochemical cycling. However, the physiological significance of this reduction process remains poorly understood, because Shewanella species are capable of reducing only low concentrations of iodate. This study…
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Artikel Jurnal
Tandem receiver domain response regulator DrdR modulates swarming by controlling PilB/PilT activity in Xanthomonas campestris
Abstract Like many other bacterial organisms, Xanthomonas campestris pv. campestris (Xcc) employs two motility appendages, a single polar flagellum and type IV pili, for sensing environmental cues and traversing liquids and solid surfaces. However, compared to the flagellum, the molecular…
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Artikel Jurnal
Functionally cured chronic hepatitis B: A cure‐related occult HBV infection state
Abstract Occult HBV infection (OBI) is characterized by the presence of replication‐competent hepatitis B virus (HBV) DNA (covalently closed circular DNA [cccDNA] and/or relaxed circular DNA [rcDNA]) in the liver and/or HBV DNA in the blood, despite negative hepatitis B surface antigen (HBsAg)…
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Artikel Jurnal
Functional characterization of a pore‐forming effector TseMt from the H4 type VI secretion system of Pseudomonas aeruginosa
Abstract Pseudomonas aeruginosa is a major nosocomial pathogen in which the type VI secretion system (T6SS) contributes to interbacterial competition and virulence. While most strains encode three T6SSs, additional T6SS clusters have been identified in clinical isolates through comparative…
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Artikel Jurnal
Pasteurella lipoprotein E interacts with host ABCF2 to facilitate adhesion and cell apoptosis
Abstract Pasteurella multocida can cause serious diseases in many animal species and humans, yet the mechanisms of its pathogenesis remain to be elucidated. In this study, we found that the lipoprotein E (PlpE) of P. multocida contributed to bacterial adhesion to host cells. Through turboID‐based…
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Artikel Jurnal
Ecosystem retrogression enhances cross‐domain microbial stability and increases the genetic potential for nutrient cycling
Abstract Ecosystem retrogression drives nutrient depletion, reduced productivity, and profound reorganization of soil microbial communities. Using amplicon sequencing and genome‐resolved metagenomics, we examined how cross‐domain microbial networks and functional gene potential respond to long‐term…
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Artikel Jurnal
Advances and challenges in experimental models for Epstein–Barr virus research
Abstract Epstein–Barr virus (EBV), the first identified human oncovirus, is a ubiquitous γ‐herpesvirus etiologically linked to diverse malignancies, lymphoproliferative disorders, and autoimmune diseases. Experimental models are pivotal for unraveling the infection and pathogenesis mechanisms, life…