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Cancer Innovation
Scopus
ISSN 2770-9183 · Wiley · 181 artikel di indeks
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Artikel Jurnal
Binary and Ternary Classification Prediction for Breast Cancer and Breast Sclerosing Adenosis With Interpretable Artificial Intelligence From Clinical and Imaging Features: A Retrospective, Diagnostic Accuracy Cohort Study
ABSTRACT Background Sclerosing adenosis (SA) and breast cancer (BC) often exhibit overlapping clinical, imaging, and pathological characteristics, making them difficult to differentiate. SA may also coexist with BC (SA + BC), including ductal carcinoma in situ (SA‐DCIS) and invasive breast cancer…
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Artikel Jurnal
Statins in Breast Cancer Therapy: Mechanistic Insights and Emerging Evidence
ABSTRACT Breast cancer (BC) remains the most frequently diagnosed malignancy worldwide, with an estimated 2.3 million new cases and approximately 685,000 deaths reported in 2020. Forecasts suggest a substantial rise in global incidence, with new annual cases projected to reach 3.2 million by 2050…
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Global, Population and Genetic Evidence on the Relationships Between Immune‐Mediated Inflammatory Disease and Cancer Risk
ABSTRACT Background Immune‐mediated inflammatory disease (IMID) and cancer share underlying mechanisms. We aimed to comprehensively evaluate the associations between IMIDs and cancers from global, population and genetic perspectives. Methods A triangulation framework was employed to assess the…
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Potential Targets and Biomarkers of Radionuclide Therapy in Breast Cancer
ABSTRACT In recent years, multidisciplinary treatment strategies have profoundly improved drug responses and survival outcomes of breast cancer (BC) patients. However, there is an urgent need for novel therapies for BC patients who are heavily treated or develop resistance to conventional treatment…
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Artikel Jurnal
An Anoikis Resistance Phenotype Converged to Immune Dysfunction and Resistance to Immune Checkpoint Blockades in Gastric Cancer
ABSTRACT Background Gastric cancer (GC) continues to pose a significant global health challenge due to its high rates of incidence and mortality, with the majority of cases identified at advanced stages. Immunotherapy, particularly immune checkpoint blockades (ICBs), has demonstrated considerable…
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AI and Big Data in Oncology: A Physician‐Centered Perspective on Emerging Clinical and Research Applications
ABSTRACT The convergence of artificial intelligence (AI) and big data is reshaping contemporary oncology by enabling the integration of multimodal information across imaging, pathology, genomics, and clinical records. From a physician‐centered perspective, these technologies can potentially be used…
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Global Burden and Temporal Trends of Brain and Central Nervous System Tumors in Children and Adolescents: A Systematic Analysis for the Global Burden of Disease Study 2021
ABSTRACT Background Central nervous system (CNS) tumors pose major global health challenges. Previous studies often assessed all‐age populations without focusing on children and adolescents. We analyzed the burden and temporal trends of CNS tumors among individuals aged
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Artikel Jurnal
Advances in the Research of Nasopharyngeal Carcinoma: A Perspective
ABSTRACT The year 2025 marked significant advances in precision medicine for nasopharyngeal carcinoma (NPC). This review summarizes recent advances in treatment strategies aimed at addressing longstanding challenges in NPC management, including treatment‐related toxicity, therapeutic resistance…
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Radioiodine‐Refractory Differentiated Thyroid Cancer: Definition, Molecular Mechanisms, and Advances in Precision Therapy
ABSTRACT Radioiodine‐refractory differentiated thyroid cancer, defined by loss of responsiveness to ¹³¹I therapy or by heterogeneous iodine uptake, accounts for the majority of thyroid cancer‐related deaths; 10‐year survival is approximately 10% with distant metastases. Its definition is not…
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Molecular and Genetic Landscape of Intravenous Leiomyomatosis: A Narrative Review
ABSTRACT Intravenous leiomyomatosis (IVL) is a rare benign smooth muscle tumor originating from the uterus and characterized by intravascular growth along the venous system, with potential extension to the inferior vena cava, right heart, or pulmonary arteries, leading to life‐threatening…
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Low‐Dose Antiangiogenic Therapy With Different Chemotherapy Backbones Among Patients With Heavily Pretreated Metastatic Breast Cancer
ABSTRACT Background The prognosis for metastatic breast cancer (MBC) remains poor, and treatment options are limited for patients with heavily pretreated disease. Although antiangiogenic agents may provide clinical benefit in this setting, real‐world evidence regarding their efficacy, safety, and…
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Clinical Advances in Breast Cancer: A Comprehensive Overview of Full‐Course Disease Management
ABSTRACT The landscape of breast cancer (BC) treatment has reached a pivotal turning point in recent years, marked by a succession of breakthrough findings from landmark international clinical trials. These advances have fundamentally reshaped treatment paradigms across distinct molecular subtypes…
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Innate Immune Cells in Non‐Small Cell Lung Cancer: Roles in Tumor Progression and Therapeutic Responses
ABSTRACT As a leading cause of cancer‐related morbidity and mortality worldwide, non‐small cell lung cancer (NSCLC) is profoundly influenced by innate immune cells (IICs). In addition to serving as key mediators of antimicrobial defense and adaptive immune activation, IICs exert pivotal and…
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BACE2 Promotes Bladder Cancer Chemoresistance Through Proteolytic Activation of JAG1‐Notch Signaling
ABSTRACT Background Chemoresistance to platinum‐based regimens, primarily gemcitabine plus cisplatin, remains a major obstacle in the treatment of advanced bladder cancer. Identifying the underlying molecular mechanisms is critical for developing effective therapeutic strategies to improve clinical…
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Multiple Primary Malignancies in Patients With Gastric Cancer: A Retrospective Study in National Cancer Center of China
ABSTRACT Background Gastric cancer (GC) is a prevalent malignancy in China, posing significant health challenges. The persistently high tumor incidence and the rising number of tumor survivors may elevate the risk of multiple primary malignancies (MPMs) in GC patients. Methods We conducted a…
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Artikel Jurnal
Treatment Advances in Gynecologic Cancers: Insights From Recent Clinical Trials
ABSTRACT Gynecologic cancers remain a major global health burden for women. Their management has evolved toward a gynecologic oncologist‐led multimodal paradigm. While these approaches have improved outcomes, critical limitations persist, including challenges in decision‐making during surgical…
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Expert Consensus on the Clinical Application of Poly ADP Ribose Polymerase Inhibitors in Breast Cancer (2025 Edition)
ABSTRACT Breast cancer represents a major threat to women's health in China. Its continuously rising incidence contributes to a growing disease burden, thereby creating a critical demand for novel and effective therapeutic strategies. In recent years, poly ADP‐ribose polymerase (PARP) inhibitors…
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Rationale and Trial Design of DAWNA‐FES Trial: Single‐Arm Phase II Study of Endocrine Therapy With Dalpiciclib After Progression on CDK4/6 Inhibition Based on [18F]FES PET/CT in Patients With HR+/HER2− Advanced Breast Cancer
ABSTRACT Background Cyclin‐dependent kinase 4/6 (CDK4/6) inhibitors have become a cornerstone in the first‐line management of hormone receptor‐positive, human epidermal growth factor receptor 2‐negative (HR+/HER2−) advanced breast cancer. Despite their clinical efficacy, most patients eventually…