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Infectious Medicine
Scopus
ISSN 2772-431X · Elsevier · 209 artikel di indeks
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Artikel Jurnal
Novel use of oral delafloxacin monotherapy in staphylococcal prosthetic valve endocarditis: A case report
Delafloxacin (DLFX), a new anionic fluoroquinolone, has been approved by the United States Food and Drug Administration (FDA) and the European Medicines Agency (EMA) for the treatment of bacterial skin and skin structure infections and by the FDA for community-acquired pneumonia. This report…
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Quantitative association of blood culture volume with contaminant and pathogen recovery
Background: Blood culture contamination is common and associated with adverse outcomes. The relation between blood culture volume and contamination remains under-evaluated. We assess the relation between blood culture volume and commensal-positive culture rate and characterize the relative…
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The impact of gut microbiota on leukemia and prospects for novel therapies
The Human Microbiome Project has underscored the pivotal role of the gut microbiome in human health, revealing its potential influence on leukemia development, progression, and treatment response. This review summarizes evidence on microbiome-targeted therapies such as probiotics, fecal microbiota…
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SpecFlu-Net: A frequency-aware neural architecture with temporal-dependency optimization for long-term seasonal influenza transmission forecasting
Background: Seasonal influenza poses severe global health and economic burdens, demanding reliable long-term (3–6 months) forecasts for proactive public-health interventions. However, influenza surveillance data exhibits four key idiosyncrasies—quasi-periodicity with drifting phase, sharp…
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Emerging hypervirulent
The global emergence of hypervirulent Klebsiella pneumoniae (hvKp) has raised concern because of its association with invasive infections and reports of increased mortality. However, recent systematic reviews and meta-analyses reveal a critical paradox: genotypically defined convergent clones and…
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A generalized multi-population model for Ebola virus transmission incorporating environmental reservoir dynamics
Background: Ebola virus disease (EVD) remains a serious public health hazard due to high mortality, multiple modes of transmission, and persistence in the environment. The existing Ebola transmission models have been constrained to a single or two-population framework, which are insufficient to…
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Performance of Xpert MTB/RIF Ultra assay for diagnosis of tuberculosis: A retrospective study in a city with intermediate tuberculosis burden
Background: Xpert MTB/RIF Ultra assay (Ultra) was shown to be useful for diagnosis of tuberculosis (TB) in areas of high and low TB burden. However, data from intermediate TB burden settings remains limited. This study aims to evaluate the performance of Ultra in Hong Kong, China, a city with…
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The 2026 Bundibugyo virus disease outbreak in the Democratic Republic of the Congo: Virology, epidemiology, continental response, and research priorities
Bundibugyo ebolavirus (BDBV), a member of the genus Orthoebolavirus , family Filoviridae , is hereafter referred to as Bundibugyo virus, with the associated illness termed Bundibugyo virus disease (BVD). First identified in Uganda in 2007, the virus has received far less scientific attention than…
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Global distribution and genomic characteristics of
Background: Shigella spp. remains a major cause of diarrheal disease globally, with escalating antimicrobial resistance and high transmissibility posing persistent public health threats. However, large-scale spatiotemporal genomic analyses are scarce, particularly for the neglected species S…
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Assessing the pandemic potential of Nipah virus: From molecular pathogenesis to ecological spillover risks
Nipah virus, a highly lethal zoonotic paramyxovirus with a case‑fatality rate of 40–75%, poses a formidable threat to global health security. This review synthesizes its evolving epidemiology, contrasting the Malaysian and Bangladesh‑India strains, and dissects molecular pathogenesis focusing on…
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Discovery of human antibody specific to the spike glycoprotein subunit 2 of SARS-CoV-2 and characterization of its broad-spectrum neutralizing activity
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to evolve and mutate during transmission, making the development of effective broad-spectrum antibodies for the prevention and treatment of SARS-CoV-2 infections of great significance. In this study, peripheral blood…
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Fatal coinfection with Oropouche virus and influenza A(H1N1)pdm09: Case report and post-mortem findings
Oropouche virus (OROV) is an emerging orthobunyavirus that causes increasingly severe and deadly disease in Brazil. However, coinfection with influenza A(H1N1)pdm09 has not been previously described in the published literature, to our knowledge. We report the first documented fatal case of OROV and…
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Genomic characteristics and tracing analysis of an acute gastroenteritis outbreak associated with rotavirus C in a boarding high school
Background: Rotaviruses are major pathogens of childhood acute gastroenteritis, dominated by rotavirus A (RVA). Outbreaks caused by human rotavirus C (RVC) are rarely reported, and relevant genomic data remain scarce. This genomic investigation of an RVC outbreak improves our understanding of viral…
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Japanese encephalitis virus reprograms host pyrimidine metabolism to facilitate viral replication
Background: Pyrimidine metabolism is crucial for the replication of viruses and the functionality of host cells. However, the cell-type-specific organization of this metabolism in the central nervous system and its dysregulation during Japanese encephalitis virus (JEV) infection remain poorly…
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Preparation and characterization of the affinity and neutralization abilities of human monoclonal antibodies against bunyavirus SFTSV glycoprotein C
Background: Severe fever with thrombocytopenia syndrome (SFTS) caused by severe fever with thrombocytopenia syndrome virus (SFTSV) has become a persistent threat to public health. Since neutralizing monoclonal antibody therapy can invoke an immediate and effective passive immunity, endeavours made…
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Nipah virus and the lessons of COVID-19: are we prepared for the next pandemic threat?
The coronavirus disease 2019 (COVID-19) pandemic has exposed profound and persistent weaknesses in global preparedness, including fragmented surveillance systems, governance failures, inequitable access to countermeasures, and erosion of public trust. Although SARS-CoV-2 has dominated global…
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Convalescent plasma for persistent symptomatic COVID-19 infection in immune-suppressed patients – a case series
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection progresses from an initial direct viral cell injury to an immune-mediated response. In most cases, the immune response results in viral clearance and recovery after a mild disease. Severe infections seem to result mainly from…
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Oxidative stress index as a potent predictor of disease severity and inflammatory burden in hospitalized COVID-19 patients
Background: While the acute phase of the COVID-19 pandemic has passed, understanding its pathophysiology remains critical for managing long-term sequelae and future viral threats. Oxidative stress is a proposed key driver of COVID-19 severity, but its relationship with the dynamic inflammatory…
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Changes in the burden of lower respiratory infections in China before and after the implementation of the national centralized drug procurement policy
Background: The implementation of the National Centralized Drug Procurement (NCDP) policy has had far-reaching effects. This study aims to assess the impact of the NCDP policy on the disease burden of lower respiratory infections (LRIs) in China. Methods: The age-standardized incidence rates…
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Artikel Jurnal
Hepatitis E virus and renal injury: A review of pathogenesis, pathology, and clinical management
Hepatitis E virus (HEV), particularly Orthohepevirus A genotypes 1–4, is a major cause of acute viral hepatitis, with genotypes 3 and 4 also recognized as important zoonotic pathogens and increasingly associated with extrahepatic renal manifestations, which have emerged as a critical clinical…