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Gastro Hep Advances
Scopus
ISSN 2772-5723 · Elsevier · 948 artikel di indeks
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Artikel Jurnal
Risk Factors for Pouch Neoplasia in Patients With Inflammatory Bowel Disease: A Case-Control Study
Background and Aims: Patients with inflammatory bowel disease (IBD) undergoing total proctocolectomy with ileal pouch-anal anastomosis remain at risk of pouch neoplasia. Prior studies, based on cohorts ending in the 2010s, identified prior colorectal dysplasia and carcinoma as independent risk…
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Artikel Jurnal
Multimodal Single-Cell Network Analysis Identifies Basigin/Cluster of Differentiation 147 as a Tumor-Associated Signaling Hub in Hepatocellular Carcinoma
Background and Aims: Hepatocellular carcinoma (HCC) ranks among the leading causes of cancer mortality globally, driven by late diagnosis and inadequate sensitivity of biomarkers like α-fetoprotein for early or indeterminate lesions. Single-cell RNA sequencing (scRNA-seq) enables precise mapping of…
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Artikel Jurnal
Food Insecurity and Chronic Liver and Gastrointestinal Conditions: A Systematic Review of Prevalence and Clinical Outcomes
Background and Aims: Food insecurity (FI), limited or uncertain access to enough food, has been linked to poor clinical outcomes. Given that dietary management is central to many gastrointestinal (GI) and hepatologic diseases, these populations may be uniquely vulnerable to the effects of FI. Our…
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Artikel Jurnal
Integrated Genetic Risk Stratification Identifies High Adenoma Detection Rates at Colonoscopy in a Real-World US Health System
Background and Aims: Colonoscopy prevents colorectal cancer through detection and removal of precursor adenomas but remains a resource-intensive for population screening. Inherited genetic risk may improve yield of adenoma detection and prioritization of colonoscopy in higher risk individuals…
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Artikel Jurnal
Unique Human Intestinal Tuft Cell Features Revealed by Pluripotent Stem Cell-Derived Mini-Guts
Background and Aims: Intestinal tuft cells are rare chemosensory epithelial cells critical for mucosal immunity. However, the molecular features of human intestinal tuft cells remain incompletely defined due to limited access to human tissue and known species-specific differences from murine…
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Artikel Jurnal
Once-Daily Oral Ozanimod for Japanese Patients With Ulcerative Colitis: Results From the Phase 2/3 J-True North Study
Background and Aims: Ozanimod is a once-daily, oral, selective sphingosine 1-phosphate receptor 1 and 5 modulator. The objective of the randomized, phase 2/3 J-True North study (NCT03915769) was to assess the efficacy and safety of ozanimod in Japanese patients with moderately to severely active…
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Artikel Jurnal
Ten Years in a Pediatric Center: Detecting Esophageal Pathology and Symptoms in Aerodigestive Patients
Background and Aims: Eosinophilic esophagitis (EoE) and gastroesophageal reflux disease (GERD) share overlapping gastrointestinal and pulmonary manifestations, often complicating timely diagnosis. Aerodigestive evaluation integrates endoscopic and bronchoscopic approaches to better characterize…
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Artikel Jurnal
ScRNA-seq Identifies High CXCL8 Linked to Liver Fibrosis in HBeAg-negative Chronic Hepatitis B Patients With Low HBsAg
Background and Aims: Chemokine ligand 8 (CXCL8) is suggested as a potential biomarker in assessing the progression and severity of hepatitis B e antigen–negative treatment-naive patients with “chronic hepatitis”. Analysis of CXCL8 expression in the liver and blood of such patients with low and high…
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Artikel Jurnal
Single-Cell Lineage Trajectory Defines Cyclin-Dependent Kinase Inhibitor–Sensitive Cells-of-Origin in Esophageal Squamous Cell Carcinoma
Background and Aims: Understanding the cells of origin is essential for overcoming therapy resistance and improving early intervention strategies in esophageal squamous cell carcinoma (ESCC). Despite recent advances in genomic profiling, the precise cellular hierarchies and molecular programs…
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Artikel Jurnal
Carbonic Anhydrase-IX Is a Specific and Sensitive Theragnostic Target for Imaging and Radioimmunotherapy in Metastatic Colorectal Cancer
Background and Aims: Over 40% of colorectal cancer (CRC) patients develop metastatic disease. Their survival outlook is very low, highlighting the urgent need to improve the detection and therapeutic management of metastatic colorectal cancer (mCRC), particularly when metastases are not surgically…
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Artikel Jurnal
Lower Health Literacy Is Associated With Greater Severity of Metabolic Dysfunction and Steatotic Liver Disease
Background and Aims: The spectrum of health literacy in metabolic dysfunction–associated steatotic liver disease (MASLD) patients and its relationship to disease severity are largely unknown. We performed an exploratory cross-sectional study regarding health literacy in this population. Methods…
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Artikel Jurnal
Recurrent Esophageal Stricture Following Caustic Injury From a Concentrated Herbal Preparation in a Resource-Limited Setting
Caustic esophageal injury is a frequently overlooked health problem, despite its serious impact on patients’ quality of life. We report the case of a 24-year-old male from an island region of Indonesia who developed esophageal stricture after consuming a traditional herbal preparation with low…