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EJC Paediatric Oncology
Scopus
ISSN 2772-610X · Elsevier · 436 artikel di indeks
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Artikel Jurnal
Experiences of receiving explanations about medical conditions among adolescent children with cancer: A qualitative study
Background: Although international consensus has been reached on the implementation of open communication for children with cancer, few studies have captured the reality of their experiences of receiving explanations of their medical conditions. This study aimed to investigate the experiences of…
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Artikel Jurnal
Large B-cell lymphoma with IRF4-rearrangement (LBCL-IRF4+) among children, adolescents and young adults (CAYA), a narrative review
Outcomes for pediatric non-Hodgkin lymphoma (NHL) have improved markedly over the past decade; however, reducing therapy-related toxicity while maintaining excellent survival remains a major challenge. This narrative review, conducted using a PCC (Population–Concept–Context) framework, summarizes…
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Artikel Jurnal
The interplay of inborn errors of immunity with hematology – Report of the joint focus meeting of ESID, EHA, and SIOPE, Vienna, Austria
The three scientific societies ESID, EHA, and SIOPe jointly organized their first focus meeting entitled “The Interplay of Inborn Errors of Immunity with Hematology,” which took place in Vienna, Austria, in November 2025 and was met with great success. The sessions addressed a wide range of topics…
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Artikel Jurnal
Five years of centralized pediatric oncology care in the Netherlands: Evaluation of diagnosis and treatment of children and adolescents with a malignant extracranial germ cell tumor
Background: Since 2018, cancer care for patients up to 18 years is concentrated in the Princess Máxima Center for Pediatric Oncology (Máxima). In this retrospective population-based study, we evaluated the diagnosis and treatment of malignant extracranial germ cell tumors (GCTs) presenting at our…
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Artikel Jurnal
Responses can be achieved with a combination of the MEK inhibitor selumetinib and dexamethasone in patients with relapsed/refractory RAS-pathway mutated acute lymphoblastic leukemia: Results of a parallel cohort, dose-finding and expansion phase I/II trial
Background: Relapsed/refractory acute lymphoblastic leukemia (ALL) remains a major clinical challenge. We have previously shown that relapsed leukemias frequently carry RAS-pathway activatingmutations that could be targeted by MEK-inhibitors in combination with glucocorticosteroids. Methods: Based…
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Artikel Jurnal
Primary central nervous system lymphomas in children and adolescents
Primary central nervous system lymphoma (PCNSL) is a rare and aggressive neoplasm usually of B-cell origin. Its occurrence is associated with age, with PCNSL affecting more often elderly patients. In adults, PCNSL is a non-germinal center B-cell lymphoma characterized by C5/MCD/MYD88 gene…
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Artikel Jurnal
Paediatric nodal marginal zone lymphoma
Paediatric nodal marginal zone lymphoma (PNMZL) is a rare low-grade mature B-cell non-Hodgkin lymphoma (NHL) that primarily affects male adolescents. It has been considered a distinct entity from the nodal marginal zone lymphoma (NMZL), given distinct epidemiology and outcomes. There is strong…
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Artikel Jurnal
Pharmacokinetic variability of mitotane in pediatric adrenocortical carcinoma and the role of CYP2B6 genotypes: a pediatric case series
Despite therapeutic drug monitoring of mitotane, achieving target plasma concentrations remains challenging. Commonly reported enzymes involved in mitotane metabolism are cytochrome P450 (CYP)3A4 and 2B6, with CYP2B6 being highly polymorphic. We evaluated the impact of CYP2B6 genotypes on achieving…
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Artikel Jurnal
Impact of disease burden and educational attainment on health-related unemployment among childhood cancer survivors: A mediation analysis within the Nordic SALiCCS research programme
Background: The interplay between underlying mechanisms of long-term social consequences after childhood cancer is largely unknown. Using a mediation analysis framework, we assessed the pathways through somatic diseases, psychiatric disorders, and educational attainment on the risk of being…
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Artikel Jurnal
Associations between motor performance, gait characteristics, and gait variability in pediatric oncology: a cross-sectional correlation study
Introduction: Advances in childhood cancer treatment have improved survival rates, shifting attention towards treatment-related physical limitations. However, evidence on gait alterations and motor correlates in pediatric oncology remains scarce. This cross-sectional correlation study explores…
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Integrating non-clinical and clinical evidence for prioritisation in paediatric oncology drug development: Regulatory experience with three PARP inhibitors
Paediatric oncology drug development increasingly relies on mechanism-based approaches. Stakeholder interactions and evolving non-clinical and clinical evidence together informed prioritisation across three PARP inhibitors from the same developer. The initial paediatric development of PARP1/2…
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Artikel Jurnal
Early and long-term patency of inferior vena cava patch reconstruction in children with renal tumour thrombus
Aim: Intravascular extension of renal tumours to the inferior vena cava (IVC)/right atrium (RA) represent a major surgical challenge. We report outcomes of IVC patch reconstruction (IVC-PR) following tumour-thrombus resection (TTR) in children. Methods: Retrospective review of all patients after…
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Artikel Jurnal
Availability, use and challenges of imaging modalities in neuroblastoma: A SIOPEN survey
Background: In children with neuroblastoma, imaging plays a central role in staging, treatment planning and response assessment. Standardized imaging procedures, including cross-sectional imaging and MIBG scintigraphy, are essential for consistency across international trials. However, the…
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Artikel Jurnal
Methodological resources to guide the collection of health-related quality of life data in paediatric cancer clinical trials: Scoping review
In paediatric oncology clinical trials, health-related quality of life data through patient-reported outcomes (PROs) provide valuable data on symptoms, functioning and quality of life during treatment. PROs can provide evidence on treatment tolerability and efficacy, facilitate regulatory review…
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Artikel Jurnal
Body image issues among adolescents and young adult cancer patients and survivors – A literature review from the STRONG AYA Project
Background: Adolescents and young adults (AYAs, aged 15–39 years) face cancer during a life phase marked by physical, psychological, and social development, in which body image plays a significant role. We aimed to: (1) describe body image issues among AYA cancer patients and survivors by…
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Artikel Jurnal
Moesin contributes to the unfavourable prognosis of glioblastoma multiforme possibly by modulating the immune checkpoint molecule B7-H3
Background and aims: Glioblastoma multiforme (GBM) is a highly malignant brain tumour and a leading cause of cancer-related deaths in children, adolescents, and young adults. Due to the limited efficacy of current therapies, novel strategies are needed to improve GBM outcomes. B7-H3 is an immune…
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Artikel Jurnal
Making shared care work: A national qualitative case study on collaborative practice in pediatric oncology
Background: In 2018, the Netherlands centralized all pediatric oncology care at the Prinses Máxima Center (Máxima), supported by a national network of 14 Shared Care centers. These centers deliver non-intensive treatment and supportive care closer to home, enabling a hybrid model of centralized…
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Artikel Jurnal
Multi-tyrosine kinase inhibitors in paediatric soft tissue sarcoma – A review
Neoadjuvant systemic treatment for paediatric patients with soft tissue sarcomas (STS) consists of conventional chemotherapy, predominantly ifosfamide and doxorubicin, with a limited role for innovative therapies. Many multi-tyrosine kinase inhibitors (mTKIs) have been developed in the past decades…
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Artikel Jurnal
Evaluation of the impact of adherence to infection prevention measures on the quality of life in children with hematologic malignancies
Purpose: The survival rate for paediatric hematological malignancies has improved significantly, shifting focus to Health Related Quality of Life (HRQOL). The objectives of this study was to investigate the impact of infection prevention lifestyle adjustments on HRQOL and to determine whether these…