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Journal of Allergy and Clinical Immunology: Global
Scopus
ISSN 2772-8293 · Elsevier · 596 articles in the index
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Journal Article
Development of a patient-centered asthma action plan for single maintenance and reliever therapy (MART)
Background: Recent guidelines recommend maintenance and reliever therapy (MART) as the preferred inhaler regimen for patients with moderate to severe asthma. However, updated asthma action plans (AAPs), specifically tailored to MART, have not been developed for the US population. Objective: We…
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Journal Article
Real-world outcomes after anti–IL-5/anti–IL-5Rα treatment for hypereosinophilic syndrome: Systematic literature review
Background: Anti–IL-5/anti–IL-5 receptor alpha (anti–IL-5/anti–IL-5Rα) treatments have potential to improve outcomes in hypereosinophilic syndrome (HES), as demonstrated in clinical trials. Objective: We sought to understand the real-world outcomes of anti–IL-5/anti–IL-5Rα treatments in patients…
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Journal Article
Number of food allergies and diet quality
Background: More than 30% of children in the US with food allergy have multiple food allergies. Food restrictions due to food allergies can affect children’s diet and growth. We hypothesized that a higher number of food allergies would be associated with poorer diet quality. Objective: Our aim was…
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Journal Article
Outcomes of the Navajo Community Asthma Program during the COVID-19 pandemic
Background: Despite elevated rates of asthma among Native American children, few interventions have been tested on tribal lands. Objective: Our aim was to test whether the Community Asthma Program reduced the number of asthma exacerbations on the Navajo Nation. Methods: Following 1 year of…
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Journal Article
Impact of prednisolone tapering and extended dupilumab dosing intervals on comorbid asthma in patients with chronic rhinosinusitis with nasal polyps
Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) frequently coexists with asthma and involves type 2 inflammation. Dupilumab enables prednisolone (PSL) tapering and extended dosing intervals in CRSwNP, but the impact on comorbid asthma is unclear. Objectives: We evaluated the impact of…
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Journal Article
Evidence for dysbiosis in the gut microbiome of patients with systemic mastocytosis
Background: Limited research studies have investigated the role of the gut microbiome in systemic mastocytosis (SM), which is characterized by an aberrant expansion of clonal mast cells in specific tissues including the skin, marrow, liver, and the gastrointestinal tract. Objectives: We sought to…
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Journal Article
Cephalosporin allergy: R1 side-chain and penicillin cross-reactivity patterns in an Australian cohort
Background: Cross-reactivity between cephalosporins, and penicillins, is mainly explained by R1 side-chain similarity. However, data on cross-reactivity patterns in cephalosporin-allergic patients, with and without preexisting penicillin allergy labels, are lacking. Objective: We sought to…
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Journal Article
Depression in children with asthma: Testing a cholinergically mediated “endotype”
Background: Asthma is not a single uniform disease; instead, it comprises various disease sub entities, or “endotypes,” with different etiologies and pathophysiologies. As asthma endotypes are discerned, individuals with asthma can be matched with optimal therapies for their specific asthma…
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Journal Article
Biomarker-guided IL-5 blockade achieves steroid-free MPO-ANCA seroconversion in EGPA
This report describes a case of biopsy-confirmed EGPA in which early initiation of mepolizumab, guided by biomarker surveillance, resulted in steroid-free MPO-ANCA seroconversion. These findings suggest a potential steroid-sparing strategy for ANCA-positive EGPA.
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Journal Article
Specialist care improves diagnosis and treatment for patients with chronic spontaneous urticaria: A real-world survey
Background: Although effective treatments and guidelines for chronic spontaneous urticaria (CSU) are available, patients often experience diagnostic delays and undertreatment. Objective: Our aim was to assess diagnostic differences and receipt of biologic treatment in patients with CSU across…
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Journal Article
Asthma biologic effectiveness by age and sex in the US CHRONICLE study
Background: Biologic therapies are effective in reducing asthma exacerbations in patients with severe asthma; however, the impact of age and sex on the real-world effectiveness of these therapies is not well understood. Objective: Our aim was to examine real-world outcomes before and after biologic…
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Journal Article
Prediction model to identify patients with hypereosinophilic syndrome using real-world data
Background: Hypereosinophilic syndrome (HES) is challenging to diagnose and identify in real-world data. Objective: We sought to develop a machine learning model to predict HES diagnosis in secondary data and estimate HES prevalence among individuals with elevated blood eosinophil count (BEC)…
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Journal Article
Birch rust allergy as a novel autumnal trigger of seasonal airway symptoms
Background: Accurate identification of allergenic triggers is essential for diagnosis, prevention, and management of airway allergies. In Tromsø (in northern Norway), birch rust (BR) spores are released in large quantities during autumn, a period with minimal dispersal of other environmental…
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Journal Article
Respiratory infections and asthma exacerbations in children: Regional insights into the overlooked role of atypical pathogens in Mexico
Background: Respiratory infections are the leading cause of asthma exacerbations in children, yet data from Latin America remain limited, especially in the postpandemic context. Understanding the respiratory pathogen landscape in pediatric patients with wheezing episodes may inform regional…
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Journal Article
Lymphedema in patients with X-linked severe combined immunodeficiency
Background: IL2RG and JAK3 mutations cause T-cell–negative, B-cell–positive, natural killer cell–negative severe combined immunodeficiency (SCID). Cell therapies such as hematopoietic stem cell transplantation (or gene therapy for IL2RG deficiency) can effectively restore T-cell immunity but—when…
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Journal Article
Food allergy and anaphylaxis in a university campus dining program
Background: The estimated prevalence of food allergy (FA) among college students is 15%. However, the risk of FA, anaphylaxis, and related outcomes in college dining halls remains unclear. Objective: We aimed to assess the landscape of food allergens and allergic reactions within a university…
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Journal Article
Maternal beliefs and asthma medication adherence during pregnancy
Background: Maintaining optimal control of asthma during pregnancy is critical, as poorly controlled asthma is associated with negative health implications for both mother and baby. However, asthma medications are frequently discontinued by patients during pregnancy. Objective: This study aimed to…
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Journal Article
Drug-induced enterocolitis syndrome with amoxicillin-containing products: A review of cases reported to the FDA adverse event reporting system and published literature
Background: Drug-induced enterocolitis syndrome (DIES) is a rare, non–IgE-mediated allergic reaction occurring 1 to 4 hours after drug ingestion. Objective: The purpose of this evaluation was to describe postmarketing reports of DIES in patients receiving amoxicillin-containing products. Methods…
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Journal Article
Trends over a decade in the prevalence and eliciting dose of peanut and tree nut allergies in Japan
Background: The prevalence of tree nuts allergy is rapidly increasing in Japan, yet the eliciting dose (ED) for tree nuts, particularly in Asian populations, has not been sufficiently investigated. Objective: This study aimed to quantify EDs for peanut, cashew nut, and walnut in Japanese patients…
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Journal Article
Biologic outcomes in patients with severe asthma and clinically relevant allergy in the CHRONICLE study
Background: Several mAb biologic therapies are approved for the treatment of severe asthma. There are limited data examining biologic outcomes in patients with allergy that has been clinically confirmed to exacerbate their asthma symptoms. Objective: Our aim was to assess rates of asthma…