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Cell Insight
Scopus
ISSN 2772-8927 · Elsevier · 172 artikel di indeks
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Artikel Jurnal
Phage tail protein methylation enabling the virus to bind to the surface of bacterial cells is vital for progeny infectivity
The importance of methylation-based protein modifications in viral infection remains largely unknown. Here, we show that phage tail protein methylation depending on a host-encoded enzyme, MepM, is vital for maintaining the viral infectivity. Inactivation of the mepM gene of Mycolicibacterium…
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Artikel Jurnal
Isolation of Rhizoma Paridis saponins as novel entry inhibitors of Crimean-Congo hemorrhagic fever virus
Crimean-Congo hemorrhagic fever virus (CCHFV) is a highly pathogenic bunyavirus, causing Crimean-Congo hemorrhagic fever (CCHF) in humans with high morbidity and mortality. Currently, there are no licensed antiviral drugs or vaccines against CCHFV, emphasizing the critical need to develop novel…
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Targeting the ICAM-1/LFA-1 adhesion axis attenuates lethal Crimean-Congo hemorrhagic fever virus infection
Crimean-Congo hemorrhagic fever virus (CCHFV) is a highly pathogenic tick-borne bunyavirus. Infection and dysfunction of the vascular endothelium are likely key factors in CCHFV pathogenesis, yet the underlying mechanisms remain poorly understood. Using a mouse model, we demonstrated that CCHFV…
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Artikel Jurnal
Identification of Foxm1 as a critical regulator for metabolic dysfunction-associated steatotic liver disease by epigenomic and transcriptional profiling
Epigenetic regulation has emerged as a key mechanism in metabolic dysfunction-associated steatotic liver disease (MASLD). However, the systematic epigenomic profiling for MASLD progression is still lacking. To investigate the epigenetic mechanisms regulating MASLD, this study performed chromatin…
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Artikel Jurnal
Challenges and opportunities: CAR-T cell therapy in autoimmune diseases
Chimeric antigen receptor T (CAR-T) cell therapy is rapidly moving from hematologic malignancies into severe autoimmune disease, particularly B cell-mediated disorders such as systemic lupus erythematosus (SLE), systemic sclerosis (SSc) and inflammatory myopathies. Recent autologous and allogeneic…
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FINE-EM-seq: a rapid isothermal amplification method enabling comprehensive methylome profiling of zebrafish early embryos
DNA methylation plays a crucial role in development and disease. Bisulfite-free methods such as enzymatic methyl sequencing (EM-seq) offer gentle approaches for whole-genome analysis, but they typically depend on PCR-based library amplification, which distorts coverage and methylation…
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Podophyllotoxin sensitizes triple-negative breast cancer cells to CD47-targeted immunotherapy
Triple-negative breast cancer (TNBC) remains a highly aggressive malignancy with limited therapeutic options. Immunotherapeutic strategies are emerging as promising avenues to improve clinical outcomes in TNBC. Among these, CD47, a critical self-protective “don't eat me” immune checkpoint against…
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Artikel Jurnal
Viperin weakens IFN-I-induced immune activity by facilitating STAT1 degradation through E3 ligase UBE4A
Viperin is considered as an antiviral protein known to directly target a variety of viruses. However, whether and how Viperin affects virus infection by targeting intracellular immune signaling remain unexplored. Here, we reveal that Viperin inhibits type-I interferon (IFN-I) antiviral immune…
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Capicua mediates interleukin-2 withdrawal–induced death of activated CD8+ T cells
During the course of an immune response, antigen-reactive T cells undergo clonal expansion and are subsequently eliminated by cytokine withdrawal-induced cell death (CWID), an intrinsic apoptotic program essential for immune homeostasis. However, the mechanisms orchestrating CWID remain poorly…
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Artikel Jurnal
Ketone body metabolism activates the immune response against Staphylococcus aureus infection by fueling the tricarboxylic acid cycle and affecting histone β-hydroxybutyrylation
Staphylococcus aureus (S. aureus) is a prominent human pathogen that causes persistent inflammation and is notoriously difficult to treat. Fasting is one of host adaptations to infection, and the induction of ketogenesis and ketolysis is a well-described host metabolic adaptation in response to…
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Artikel Jurnal
Lipid-associated macrophages and metabolic inflammatory diseases
Lipid metabolism disorders have been identified in various chronic diseases that are also closely linked with immune cells and inflammatory microenvironment. As pivotal innate immune cells, macrophages exhibit remarkable heterogeneity. Lipid-associated macrophages (LAMs) have emerged as a distinct…
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Artikel Jurnal
Molecular basis of fox ACE2 recognition by receptor binding domains of SARS-CoV-2 and PCoV-GD
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positive RNA detected in red fox swab samples provide evidence of a natural SARS-CoV-2 infection in this species. Many studies have also demonstrated that the red fox angiotensin converting enzyme 2 (fACE2) could serve as the receptor…
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Viral-host interactions mediated by the mTOR signaling pathway
The mechanistic target of rapamycin (mTOR) is an evolutionarily conserved serine/threonine kinase that regulates multiple key cellular processes. It assembles into two major multi-protein complexes, called mTOR complex (mTORC)1 and mTORC2, to integrate cues from cellular nutrient status, energy…
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Artikel Jurnal
TNF inhibits SARS-CoV-2 induced cell-cell fusion through activating the SDC4-RhoA signaling to promote actin bundles formation
SARS-CoV-2 infection-induced syncytia formation accelerates cell-to-cell transmission of the virus and enhances viral evasion by neutralizing antibodies. Host innate immune response plays a key role in controlling viral infection. Our present work identifies tumor necrosis factor (TNF) as a key…
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Tuning the state: Matching condensate material properties with physiological demands and pathological dysfunction
Biomolecular condensates have emerged as fundamental organizers of cellular biochemistry. Increasing evidence indicates that cellular condensates exhibit a broad spectrum of material properties—including viscoelastic, soft glass-like, gel-like, and quasi-solid regimes—that are intimately coupled to…
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Structural and mechanistic basis of ADAR1-mediated RNA editing and immune regulation
Adenosine deaminase acting on RNA 1 (ADAR1) is a central regulator of innate immunity. By binding to and catalyzing adenosine-to-inosine deamination within double-stranded RNAs, ADAR1 mitigates the immunogenicity of self-derived RNAs and preserves cellular homeostasis. In this review, we summarize…
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Artikel Jurnal
Phosphorylation of FBXL3 mediates GLDC polyubiquitination to suppress MHC-I expression and promote cancer immune evasion
Glycine decarboxylase (GLDC) is overexpressed in multiple tumor types and contributes to tumorigenesis or immune evasion by unclarified mechanisms. Here we report that GLDC is polyubiquitinated at K636 following EGFR activation, which drives GLDC-dependent transcriptional inhibition of MHC-I genes…