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Oral Oncology Reports
Scopus
ISSN 2772-9060 · Elsevier · 755 artikel di indeks
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Artikel Jurnal
Artificial intelligence in oral cancer: a feasibility study informed by Freud's case
Objective: To test whether a locally hosted, retrieval-augmented clinical decision framework (CDF) improves recognition of cocaine-induced midline destructive lesions (CIMDL)—a malignancy mimicker—during dental teleconsultation, compared with a cloud large language model (LLM) without retrieval…
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Artikel Jurnal
HER3 and HPV in head and neck squamous cell carcinoma: Potential implications of induction chemotherapy on tumor immune microenvironment
Background: Receptor tyrosine-protein kinase erbB-3 (HER3) is frequently overexpressed in head and neck squamous cell carcinoma (HNSCC) and is typically associated with chemotherapy resistance and poor prognosis. However, the dynamics of HER3 expression following induction chemotherapy (ICT) remain…
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Targeting the angiotensin II/AT1R pathway and reactive oxygen species to mitigate oral mucositis: Mechanistic insights and therapeutic evidence
Oral mucositis (OM) is a common, severe, and dose-limiting toxicity of radiotherapy and chemotherapy, particularly in patients with head and neck malignancies or those undergoing hematopoietic stem cell transplantation. Affecting up to 80–100% of irradiated patients and approximately 40% of those…
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Exploratory analysis of neutrophil-to-lymphocyte ratio dynamics and pathologic response to neoadjuvant nivolumab in head and neck squamous cell carcinoma
Neutrophil to lymphocyte ratio (NLR) is an inflammatory index with prognostic value in a variety of solid tumors. It is easily derived from routine blood tests, and elevated ratios have shown association with poor outcomes in several settings. However, the association of NLR with response to…
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Diagnostic accuracy of sentinel lymph node biopsy in clinically early-stage (cT1-2N0) oral tongue squamous cell carcinoma: A prospective study
Background: Accurate staging of the clinically node-negative neck remains a major challenge in clinically early-stage (cT1–T2N0) oral tongue squamous cell carcinoma (OTSCC). Sentinel lymph node biopsy (SLNB) has emerged as a less invasive alternative to elective neck dissection (END), the…
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Artikel Jurnal
Programmed cell death ligand 2 (PD-L2) expression is inversely correlated with human papillomavirus status in oropharyngeal squamous cell carcinoma (OPSCC) tumors
The incidence of oropharyngeal squamous cell carcinoma (OPSCC) associated with infection by the human papillomavirus (HPV) continues to increase and 71% of OPSCC cases in the United States are HPV+. We have previously performed microRNA profiling of HPV+ vs HPV- OPSCC and identified miR-106b as…
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Artikel Jurnal
Compromised cervical lymphatic drainage following lymphadenectomy and radiation: an overview of head and neck lymphedema and its emerging pathophysiological implications
The critical function of the lymphatic system is to support tissue homeostasis through clearance of interstitial fluid. Lymphatic drainage from the head and neck tissues converges at the cervical lymphatic system, the central gateway through which lymph enters the peripheral blood. Surgical…
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Artikel Jurnal
Radiologic mandibular re-ossification after intra-arterial chemoradiotherapy with a proton beam boost for oral cancer with mandibular invasion: a case series
Background: Cases of oral squamous cell carcinoma (OSCC) with mandibular invasion have traditionally been considered indications for surgical resection because definitive radiotherapy has been associated with suboptimal tumor control and a substantial risk of osteoradionecrosis (ORN). Structural…
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Patterns of facial (Level IX) node metastasis in head and neck cancer: Multicenter data supporting sublevel IXa/IXb delineation
Purpose: Bucco-facial nodes are at risk of harboring metastases from mucosal cancers of the skin, nose, maxillary sinus, and buccal mucosa. The incidence of level IX involvement is not well established but likely below 10%. This multicenter study aims to evaluate the incidence of metastases to…
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Artikel Jurnal
Complete metabolic response to combined
Background: Parotid gland adenocarcinomas are rare malignant tumors within the broader group of salivary gland carcinomas, accounting for 3% to 6% of head and neck cancers. BRAF mutations are exceptionally rare in this histology, and evidence supporting BRAF -targeted therapy remains limited to…
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Sarcopenia is associated with poor swallowing outcomes after resection and free flap reconstruction for oral cancer
Objectives: To assess the relationship between radiographically identified sarcopenia and posttreatment swallowing function in patients undergoing primary resection and free flap reconstruction for squamous cell carcinoma of the oral cavity. Materials and methods: Skeletal muscle area was measured…
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IRF1 reduces new genes expression and diminishes cell proliferation and invasiveness in OSCC
IRF1 is a transcription factor, initially identified as part of the interferon response (IFN) pathway. It regulates genes involved in immune responses, cell growth, apoptosis, and DNA damage responses. However, the molecular basis of deregulated metabolism in OSCC progression is unknown. Although…
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The relationship of worst pattern of invasion (WPOI) with clinicopathological parameters: A retrospective cohort study
Rationale and objective: The worst pattern of invasion (WPOI) has been in the last few years a highly studied pathological parameter. There is a clear trend of non-cohesive WPOI (4-5) to be highly aggressive and to affect outcomes negatively. The aim of this study was to investigate the link…
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A 66-year-old female patient with folliculoma metastasis to cervical lymph nodes. Case report
Correct diagnosis of cervical cystic lesion might prove difficult - while in most cases those are benign, malignant diseases must be taken into consideration. We would like to present a case of a 66-year-old female patient with folliculoma metastasis to cervical lymph nodes - primarily recognised…
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Artikel Jurnal
LeChat in oral pathology: Assessment of its immunohistochemical marker selection accuracy in salivary gland tumors
Background: Artificial intelligence (AI) is increasingly integrated into pathology, but its accuracy in immunohistochemical (IHC) marker selection remains underexplored. This study evaluated LeChat's ability to recommend IHC markers for benign and malignant salivary gland tumors, focusing on…
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Artikel Jurnal
Adenomatoid odontogenic tumor mimicking nasal pathology: A case report on endoscopic endonasal management
Background: Adenomatoid odontogenic tumor (AOT) is a rare benign epithelial odontogenic tumor that typically occurs in young females and is most often associated with an impacted maxillary canine. Although usually managed via transoral enucleation, endoscopic endonasal surgery has emerged as a…
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Artikel Jurnal
Durable partial response of pulmonary metastases from primary sublingual gland squamous cell carcinoma after pembrolizumab failure: Salvage therapy with paclitaxel plus cetuximab
Background: Primary squamous cell carcinoma (SCC) of the sublingual gland is an extremely rare salivary gland malignancy with limited treatment options, particularly once distant metastases develop. Immune checkpoint inhibitors (ICIs) such as pembrolizumab have demonstrated efficacy in…
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Artikel Jurnal
The role of artificial intelligence in predicting cancer immunotherapy response
Cancer immunotherapy has emerged as a groundbreaking approach in oncology, leveraging the immune system's ability to target and eliminate tumor cells. Despite its success, the variability in patient responses to immunotherapy poses a significant challenge, necessitating the development of robust…