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Advocacy Priorities of the American College of Cardiology at the 2025 Legislative Conference

Amrin Kharawala, MD; David Winchester, MD, MS; Anna E. Bortnick, MD, PhD, MSc

JACC: Advances, Vol. 5 No. 3 · 2026 · Inggris · DOAJ Scopus

Prehabilitation in Patients Undergoing Cardiac Procedures

Carolin Steinmetz, PhD; Phuc Thien Tran, PhD; Stephanie Heinemann, PhD dkk.

JACC: Advances, Vol. 5 No. 3 · 2026 · Inggris · DOAJ Scopus

Background: Evidence supporting prehabilitation before cardiac procedures is growing, but the efficacy of different components remains unclear. Objectives: The primary aim was to assess the efficacy of prehabilitation on clinical outcomes based on recent randomized controlled trials (RCTs). The…

Automated Abdominal Aortic Calcification Scores and Atherosclerotic Cardiovascular Disease in the UK Biobank Imaging Study

Marc Sim, PhD; James Webster, PhD; Cassandra Smith, PhD dkk.

JACC: Advances, Vol. 5 No. 3 · 2026 · Inggris · DOAJ Scopus

Background: Abdominal aortic calcification (AAC) is a subclinical measure of atherosclerotic cardiovascular disease (ASCVD). AAC can be captured on lateral spine images obtained from bone density machines during routine osteoporosis screening. Identifying individuals with AAC provides a new…

VExUS Point-of-Care Ultrasound Tool to Detect Changes in Volume Status

Katarina Leyba, MBA, MD; August Longino, MD; Ryen Ormesher, MD dkk.

JACC: Advances, Vol. 5 No. 3 · 2026 · Inggris · DOAJ Scopus

Background: Venous excess ultrasound score (VExUS) is an emerging point-of-care ultrasound tool to evaluate venous congestion using inferior vena cava (IVC) diameter and hepatic vein pulse-wave Doppler. The utility of VExUS to detect changes in intravascular volume is not well established…

Impact of Varying Resuscitation Proportions of Resuscitated Patients on VA-ECMO Outcomes in the ECLS-SHOCK Trial

Tharusan Thevathasan, MD; Uwe Zeymer, MD; Anne Freund, MD dkk.

JACC: Advances, Vol. 5 No. 3 · 2026 · Inggris · DOAJ Scopus

Use of Electrocardiograms to Identify Coronary Artery Disease

Michael Leasure, BA; Indu Poornima, MD; Adam Butchy, PhD dkk.

JACC: Advances, Vol. 5 No. 3 · 2026 · Inggris · DOAJ Scopus

Background: The current gold standard for the diagnosis of coronary artery disease (CAD) is invasive angiography; however, it is an invasive procedure. Therefore, we developed an artificial intelligence model designed to predict significant CAD from a resting digital 12-lead electrocardiogram…

Impact of Device Insertion Technique on Impella CP Position and Orientation Within the Left Ventricle

Luca Baldetti, MD; Alessandro Beneduce, MD; Christoph Vanwersch, BA dkk.

JACC: Advances, Vol. 5 No. 3 · 2026 · Inggris · DOAJ Scopus

Background: Impella CP malrotation diminishes the unloading effect of the device. There is a paucity of data informing on the insertion procedural factors associated with malrotation. Objectives: The aim of the study was to analyze the impact of each device insertion step on the final orientation…

Targeted Therapy for Hypertension in Pregnancy

Michael Ceulemans, PharmD, PhD; Ruben Heremans, MD, PhD; Chahinda Ghossein, MD, PhD dkk.

JACC: Advances, Vol. 5 No. 2 · 2026 · Inggris · DOAJ Scopus

Reply

Victor Dayan, MD, PhD; Deepak L. Bhatt, MD, MPH, MBA

JACC: Advances, Vol. 5 No. 2 · 2026 · Inggris · DOAJ Scopus

Challenging the TAVR-Centric Approach in Asymptomatic Severe AS

David Rose, MD, PhD; Grzegorz Laskawski, MD; Cristiano Spadaccio, MD, PhD

JACC: Advances, Vol. 5 No. 2 · 2026 · Inggris · DOAJ Scopus

Reply

Stephanie A. Leonard, MS, PhD; Elliott K. Main, MD; Mark A. Hlatky, MD dkk.

JACC: Advances, Vol. 5 No. 2 · 2026 · Inggris · DOAJ Scopus

Trends in Mortality Associated With Ischemic Heart Disease and Screenable Cancers in the United States, 1999 to 2024

Jamal S. Rana, MD, PhD; Reed Mszar, MPH, MS; Eugenia Gianos, MD dkk.

JACC: Advances, Vol. 5 No. 2 · 2026 · Inggris · DOAJ Scopus

FDA Cardiovascular Indication Expansion and Dispensing of Semaglutide/Tirzepatide in CVD Patients With Overweight/Obesity

Dzuy Do, PhD; Karthik Murugiah, MBBS, MHS; Mitsuaki Sawano, MD, PhD dkk.

JACC: Advances, Vol. 5 No. 2 · 2026 · Inggris · DOAJ Scopus

Prognostic Impact of Recreational Drug Use on 1-Year Outcomes in NSTEMI and STEMI Patients

Michael Aboujaoude, MD; Nefissa Hamache, MD, PhD; Jean Guillaume Dillinger, MD, PhD dkk.

JACC: Advances, Vol. 5 No. 2 · 2026 · Inggris · DOAJ Scopus

Background: Recreational drug use is increasingly associated with adverse outcomes in acute coronary syndrome (ACS) patients, but differences in long-term outcomes between ST-segment elevation myocardial infarction (STEMI) and non-ST-segment elevation myocardial infarction are not well defined…

Impact of Left Atrial Strain on Severe Mitral Regurgitation Due to Mitral Annular Calcification

Mohammad Al Zein, MD; Yuichiro Okushi, MD; Shinya Unai, MD dkk.

JACC: Advances, Vol. 5 No. 2 · 2026 · Inggris · DOAJ Scopus

Background: Mitral annular calcification (MAC) is a progressive degenerative condition characterized by calcium deposition on the mitral apparatus, and is associated with adverse outcomes. Data on mitral regurgitation (MR) caused by MAC are limited. Objectives: This study evaluates the prognostic…

Aortic Stenosis in Homozygous Familial Hypercholesterolemia

Armen Erzingatzian, BSc; Zobaida Al-Baldawi, MD, MSc; Isabelle Ruel, PhD dkk.

JACC: Advances, Vol. 5 No. 2 · 2026 · Inggris · DOAJ Scopus

Background: Homozygous familial hypercholesterolemia (HoFH) is a rare genetic disorder characterized by extreme elevations in low-density lipoprotein cholesterol levels and premature cardiovascular disease. Objectives: The objective of this study was to assess the prevalence, clinical presentation…

Cardiac Diffusion Tensor Imaging May Detect Early Cardiac Amyloidosis in Carpal Tunnel Syndrome

Fayez Kanj, BS; Danielle Kara, PhD; Emma Wexler, MA dkk.

JACC: Advances, Vol. 5 No. 2 · 2026 · Inggris · DOAJ Scopus

Background: Cardiac amyloidosis (CA) occurs when amyloid fibrils deposit in the myocardium, leading to diastolic dysfunction and subsequent heart failure. An early symptom of systemic amyloidosis is carpal tunnel syndrome (CTS). The prevalence of CTS in patients with transthyretin amyloidosis has…

U-Shaped Lipid-CVD Links in Older Adults

Xiaoxin Ye, MPH; Shengyan Du, MPH; Shimin Chen, PhD dkk.

JACC: Advances, Vol. 5 No. 2 · 2026 · Inggris · DOAJ Scopus

Background: Guidelines and consensus statements lack consistent management targets and ranges for low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) in older adults. Objectives: The objectives of the study were to investigate the relationships of LDL-C and…

Wireless Movement Activity and Cardiometabolic Disease Risk in Historical Redlined Areas

Tong Zhang, MS; Sai Rahul Ponnana, MS; Santosh Kumar Sirasapalli, MS dkk.

JACC: Advances, Vol. 5 No. 2 · 2026 · Inggris · DOAJ Scopus

Background: Composite mobility patterns may better model built environment exposures, yet are rarely implemented to understand the prevalence of cardiometabolic disease (CMD). Objectives: The purpose of this study was to investigate the association between a novel Wireless Movement Index (WMI) and…

Association Between Inflammation and Risk of Cardiovascular Mortality in Cancer Survivors

Quan Yang, MD; Jiazhen Zheng, PhD; Chunting Zhao, MD dkk.

JACC: Advances, Vol. 5 No. 2 · 2026 · Inggris · DOAJ Scopus

Background: Cancer and cardiovascular disease are closely linked, contributing to high mortality rates and significant disease burden. Inflammation serves as a common risk factor for both conditions, yet there is a lack of data on systemic inflammation and its impact on cardiovascular mortality in…