141 hasil
Menampilkan 1–20 · 0,15 detik · RSS
Archives of Advances in Biosciences
ISSN 2783-1264 · SBMU Journals · 141 artikel di indeks
-
Artikel Jurnal
The Study of the Association in between CHRNA 5 gene polymorphism (rs16969968) and chronic obstructive pulmonary disease
Introduction: Chronic obstructive pulmonary disease (COPD) is a complex, chronic inflammatory disorder of the respiratory system that primarily affects the distal airways and lung parenchyma. Genetic factors are known to contribute to COPD susceptibility. The present study aimed to investigate the…
-
Artikel Jurnal
Abnormal hemoglobin variants – a single center hospital-based study: Comparison of sensitivity of three red cell indices for the diagnosis of beta thalassemia trait
Introduction The frequency of beta thalassaemia gene in India is 3.3 %, with regional variations. There is lack of data regarding the prevalence of beta thalassaemia in the state of Kerala. We studied the clinical and haematologic profile of cases with haemoglobinopathy, with special emphasis on…
-
Artikel Jurnal
Development and Experimental Evaluation of a Multi-Epitope Nanolipopeptide Platform Targeting PD-1, PD-L1, and HER2 for Gastric Adenocarcinoma Immunotherapy
Background:To design and experimentally validate a multi-epitope nanolipopeptide vaccine targeting three key molecules—PD-1, PD-L1, and HER2—for immunotherapy of gastric adenocarcinoma. Design: Using immunoinformatics, linear B‑cell epitopes were predicted from each target protein and screened for…
-
Artikel Jurnal
In Vitro Cytotoxicity and Genotoxicity Assessment of a DSPCar-AmB Nanocarrier Using MTT and Ames Assays
Background: Amphotericin B (AmB) is a potent antifungal agent with dose-dependent toxicity. A DSPCar-based nanoliposomal formulation of AmB was previously developed and showed improved antifungal activity. This study aimed to evaluate its in vitro safety profile, including cytotoxicity and…
-
Artikel Jurnal
The Role of Antibodies against the COML to Combat Acinetobacter baumannii Antibiotic Resistance
Introduction: When treating infectious diseases, resistance to antimicrobial medications leads to issues. One of the proteins involved in the transformation of a resistant plasmid is COML, the DNA's absorbent protein. Acinetobacter baumannii's outer membrane contains this protein. The…
-
Artikel Jurnal
Chlorogenic Acid Mitigates Phenyl Hydrazine-Induced Haemolytic Anaemia and Associated Oxidative Stress in Swiss Mice
Background and Aim: Haemolytic anaemia has been the bane of several blood borne diseases like malaria, and it appears intractable especially in endemic areas like the tropics and developing economies. It is characterized by decreased red blood cells, severe haemoglobinuria, jaundice, and fatalities…
-
Artikel Jurnal
Association of rs2910164, rs57095329 polymorphisms in miR146a and rs11614913 polymorphisms in miR196a2 with susceptibility to type 2 diabetes
Background and Aim: Studies have confirmed the significance of microRNAs (miRNAs) in various biological processes. Various miRNAs have been studied in diabetes mellitus, among them miR-146a and miR-196a2 play an important role in the development of this disease. This research aims to examine the…
-
Artikel Jurnal
Non-Invasive ELF Magnetic Fields Suppress Bladder Cancer Cell Viability through Apoptotic Pathways
Background and Aim: This study was undertaken to rigorously investigate the effects of extremely low-frequency magnetic fields (ELF-MF) on bladder cancer cells and apoptosis-related pathways. Methods: T24 and 5637 cell lines were exposed to a 6 mT, 50 Hz magnetic field for 2 hours per day over…
-
Artikel Jurnal
A Novel Parameter Derived from Platelet Histograms: Pre-Peak to Post-Peak Ratio and Its Correlation with Platelet Recovery in Thrombocytopenic Patients
Background and Aim: Automated hematology analyzers generate platelet indices and histograms that can provide insight into platelet dynamics. This study evaluates a novel parameter—the pre-peak to post-peak ratio from platelet histograms—and its associations with the percentage of giant platelet…
-
Artikel Jurnal
Comprehensive Mechanistic Mapping of ROS Driven Oncolysis for Precision Therapeutics
Contex: Reactive oxygen species (ROS) have a contradictory function in cancer biology because they promote both oncogenic signaling and mediate cell death. At the molecular level, ROS are composed of free radicals like superoxide (O2•⁻), hydroxyl radicals (•OH) and peroxynitrite (ONOO-), as well as…
-
Artikel Jurnal
Nanoliposome-Based Multi-Epitope Vaccine Targeting AFP, GPC3, and TERT Modulates Inflammatory Gene Expression in the Spleen: A Preclinical Study in a Murine Model of Hepatocellular Carcinoma
Background: Hepatocellular carcinoma (HCC) is an aggressive malignancy with limited response to conventional immunotherapies. Multi-epitope vaccines targeting multiple tumor-associated antigens (TAAs) such as alpha-fetoprotein (AFP), glypican-3 (GPC3), and telomerase reverse transcriptase (TERT)…
-
Artikel Jurnal
Effect of Vitamin C antioxidant, Ag and TiO2 Nano-Particles on hsa-circ-0001518 Expression in Brain Tumor-bearing BALB/c Mice
Background and Aim: Brain cancer is a leading cause of mortality, posing significant treatment challenges. CircRNAs are emerging as innovative biomarkers and therapeutic targets for various diseases, including cancers. This study evaluates the half maximal inhibitory concentration (IC50) of Vitamin…
-
Artikel Jurnal
BCc1 Nanomedicine Modulates Splenic Cytokine Networks to Enhance Antitumor Innate Immunity in a Murine Breast Cancer Model
Breast cancer remains a leading cause of mortality among women worldwide. Emerging nanomedicine strategies, including BCc1, offer the potential to enhance antitumor immunity while minimizing treatment-associated toxicity. Here, we investigated the immunomodulatory effects of BCc1 nanomedicine on…
-
Artikel Jurnal
Immunological Characterization of a Nanoliposome-Formulated Peptide Vaccine Designed to Target CEA and TAG-72 Epitopes in HT29 Colorectal Cancer Cells
Background: Colorectal carcinoma constitutes a predominant global health challenge, ranking fourth in incidence and fifth in cancer-attributed fatalities worldwide. Epidemiological evidence from Iran demonstrates a concerning upward trajectory, with incidence rates in northern provinces surpassing…
-
Artikel Jurnal
Time-Dependent Expression Alterations of CDK1, MCM6, FBXO5, and EXO1 Cell Cycle Genes in a Colon Cancer Cell Line Under Simulated Microgravity
Introduction: Microgravity can affect gene expression in cancerous cells. The objective of this study is to evaluate the changes in the expression of CDK1, MCM6, FBXO5, and EXO1 genes in the LS180 colon cancer cell line under simulated microgravity. Materials and Methods: The cells were incubated…
-
Artikel Jurnal
Metabolic Dysfunction-Associated Steatotic Liver Disease in General Medicine: From Incidental Fatty Liver to Cardiometabolic Risk Stratification
Context: Metabolic dysfunction-associated steatotic liver disease (MASLD) has replaced non-alcoholic fatty liver disease in contemporary nomenclature and reframes hepatic steatosis as a multisystem cardiometabolic condition. In general medicine, the usual presentation is incidental steatosis on…
-
Artikel Jurnal
Adulterations in Medicinal Plants and Herbal Medicines: Role of Universities in Quality control Assessment
The use of medicinal plants is increasing worldwide; however, absence of effective quality assurance has resulted in presence and presentation of adulterations. Adulteration appear intentionally or unintentionally, both of which come to serious consequences for public health. The present policy…
-
Artikel Jurnal
Social Innovation: A Critical Mechanism for Translating Genetic Research into Public Health Practice
Context: Advances in genetics, genomics, and precision medicine have created unprecedented opportunities to improve population health. However, translating these scientific breakthroughs into equitable public health practice remains a major challenge, particularly in low- and middle-income…
-
Artikel Jurnal
Iron-doped boron nitride nanocage for targeted delivery of 5 fluorouracil: A DFT guided experimental study with in vitro validation
Background and Aim: 5-Fluorouracil (5-FU) is a widely used anticancer drug but suffers from severe systemic toxicity, short half-life, and low tumor selectivity. Boron nitride nanocages have emerged as promising drug delivery vehicles due to their high biocompatibility and low cytotoxicity…
-
Artikel Jurnal
Assessment of MUC17 and MUC13 Gene Expression Levels in Tissue Samples of Patients with Colorectal Cancer
Background and Objective: Cancer is a genetically heterogeneous disease and remains one of the leading causes of mortality worldwide. Colorectal cancer (CRC) is the third most common cancer globally and accounts for approximately 38% of gastrointestinal malignancies. It is the most prevalent cancer…