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Iranian Journal of Colorectal Research
ISSN 2783-2430 · Shiraz University of Medical Sciences · 327 articles in the index
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Encapsulating Peritoneal Sclerosis: A Rare Cause of Acute and Recurrent Abdominal Pain; A Case Report of Abdominal Cocoon Syndrome
Encapsulating peritoneal sclerosis (EPS), also known as abdominal cocoon syndrome, is a rare condition thatmay present with abdominal pain or intestinal obstruction due to the encasement of bowel loops within afibrocollagenous membrane. We report the case of a 27-year-old woman who presented with…
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Endoscopic Retrograde Appendicitis Therapy – A Review of an Innovative Appendix Preserving Treatment Modality
Acute appendicitis (AA) is one of the most frequent surgical emergencies and typically results from obstructionof the appendiceal orifice. Currently, laparoscopic appendectomy is the gold standard treatment for appendicitis.However, recent research has demonstrated the importance of the vermiform…
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Finding New Biomarkers and Therapeutic Targets for Gastric Cancer Using a System Biology Approach
Background: Gastric cancer is one of the leading causes of cancer-related mortality worldwide, withapproximately one million new cases diagnosed annually. Identifying key genes involved in this cancer iscrucial for proposing suitable therapeutic targets and facilitating early diagnosis. This study…
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The FODMAP diet for Gut Microbiome Restoration in Patients with Irritable Bowel Syndrome: A Narrative Review
Irritable Bowel Syndrome (IBS) is a multifactorial, debilitating, complex, and chronic disorder of gut-braininteraction. The Gut microbiota and its metabolites play an important role in the etiology, pathogenesis, andpathophysiology of IBS. Dietary modulation of the gut microbiome to correct gut…
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Identifying Effective Pathways and Genes in Colorectal Cancer according to Stage by Analyzing RNA Sequencing Data
Introduction: Colorectal cancer (CRC) is the second leading cause of cancer-related mortality worldwide.Numerous studies have demonstrated dysregulated gene expression in CRC. However, comprehensiveinvestigations are still needed to clarify the underlying biological pathways disrupted by these…
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Life-Threatening Mallory-Weiss Tears: From Upper Gastrointestinal Bleed to Multisystem Crisis - A Case Report
Introduction: Hypoxic respiratory failure, defined as arterial oxygen tension (PaO₂)
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The Role of Gut Microbiome Dysbiosis in Colorectal Cancer: Correlation, Molecular Mechanisms, and Probiotic Potential
The gut microbiome is an extensive and vital community of microbes in the gastrointestinal tract which iscrucial for human health as it creates beneficial compounds, aiding fiber digestion, and enhancing the immunesystem. Colorectal cancer (CRC) is the third most common cancer and second leading…
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Patient Perceptions of Minimally Invasive Robotic Surgery: A Systematic Review
Advances in digital and mechanical technologies have profoundly transformed modern surgery. Since itsapproval by the Food and Drug Administration in 2000, the widespread integration of robotic-assisted surgery(RAS) has created a complex ethical and political dynamic involving patients, healthcare…
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In Which form of Inflammatory bowel Disease Is Reduction in Quality of Life more Common: Ulcerative Colitis or Crohn’s Disease?
Background: Despite differences in histopathological features and prognostic characteristics betweenulcerative colitis and Crohn’s disease, the difference in the patients’ quality of life with these two conditionsremains unclear. Our goal was to evaluate the differences in various aspects of the…
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The Effect of Asacol (Mesalazine) Suppository on the Healing of Acute Fissures Caused by Diarrhea: A Randomized Controlled Trial
Background: An anal fissure is a linear, superficial tear in the squamous epithelium of the anus, specifically inthe anoderm distal to the dentate line. Given the well-established anti-inflammatory properties of mesalazine inacute conditions, it helps prevent secondary stricture and reduces the…
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Could L-Arginine Be a Feasible Treatment for Chronic Anal Fissure?
Anal fissure is a common benign anorectal condition characterized by a small, painful ulcer in the skin of the anal canal below the dentate line, which gradually leads to spasm of the internal sphincter muscle.
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Effects of ABO Blood Groups and Helicobacter pylori on COVID-19 Susceptibility and Disease Severity: Findings from a Cross-Sectional Analysis
Background: The investigation of the correlation between ABO blood groups and susceptibility to infectiousdiseases, particularly COVID-19 and Helicobacter pylori (H. pylori), has garnered significant scholarlyattention in recent studies. This study aimed to evaluate the association between ABO…
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Irritable Bowel Syndrome Ameliorated Dramatically with a Plant- based Diet: A Case Report
Irritable bowel syndrome (IBS) is a common disease. The first-line therapy is dietary modification. However,the current recommended diets for IBS are not effective in roughly half of patients. We encountered a 28-year-old woman with IBS with diarrhea. She was referred to us by a pediatric…
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Incidentally Diagnosed Breast Cancer in a Patient with Rectal Cancer: A Case Report
The development of screening and therapeutic approaches has improved the prognosis of colorectal cancer(CRC) patients, leading to an expected increase in the incidence of second primary cancers (SPCs). CRC hasbeen correlated with several extracolonic SPCs, including malignancies of the small…
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Exploring the Use of Skin Staples for Bowel Anastomosis: A Scoping Review
Background: Intestinal staplers have revolutionized gastrointestinal surgery by facilitating faster bowel anastomoses, achieving outcomes comparable to hand-sewn techniques. However, their high cost restricts routine use in resource-limited settings, leading to increased interest in using skin…
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Presentation and Outcomes of Patients with Colorectal Malignancies Undergoing Emergency Surgery – Experience from a Tertiary Care Centre in India
Background: Patients with colorectal cancer (CRC) presenting acutely to the emergency department vary in their physiological statuses and disease stages, necessitating a tailored surgical approach. This study assessed the presentation, surgical management, and perioperative outcomes of emergency…
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Is L-Arginine Ready for Clinical Use in Chronic Anal Fissure?A Critical Appraisal of the Current Evidence
Chronic anal fissure (CAF) is a common benign anorectal condition driven by internal anal sphincter hypertonicity and impaired anodermal perfusion, often resulting in persistent symptoms and high recurrence rates after medical therapy. L-arginine has recently been proposed as a conservative…
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Evaluation of the Synergistic Effects of Photobiomodulation and Natural Killer Cell Therapy in a Colorectal Cancer Xenograft Mouse Model
Background: Colorectal cancer (CRC) is a major cause of cancer-related mortality worldwide, highlightingthe need for more effective therapeutic approaches. This study aimed to evaluate the synergistic antitumoreffects of combining natural killer (NK) cell-based immunotherapy with photobiomodulation…
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Dolichocolon: A Narrative Review of an under-Recognized Disorder
Dolichocolon is an anatomical variant that is often under-recognized but has significant clinical implications.It is characterized by an abnormally elongated and redundant colon, distinguishing it from megacolon,which involves an increase in the colon’s diameter. This condition can cause a wide…
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Advances in Perineal Reconstruction After Abdominoperineal Resection: A Narrative Review of Techniques, Algorithms, and Future Directions
Advances in rectal cancer treatment in the modern medical era have brought increased attention to wound complications, quality of life, and the recovery process. Consequently, perineal wound complications have become a significant concern following abdominoperineal resection (APR) for rectal and…