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Journal of Current Oncology and Medical Sciences
ISSN 2783-3127 · Zabansaraye Parsian Novin Mehr Institute · 154 artikel di indeks
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Artikel Jurnal
Examining the frequency of brain tumors in Porsina Hospital in Rasht based on pathological and surgical characteristics
Introduction: Understanding the frequency of malignant and non-malignant brain tumors is crucial for understanding disease causes. Factors such as histological type, age of diagnosis, sex, and race are considered. Identifying risk factors such as allergy, ionizing radiation, and hereditary factors…
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Artikel Jurnal
Clinicopathological features of oral squamous cell carcinoma in patients referred to Amir al-Momenin and Velayat Hospitals in Rasht, Iran, from 2020 to 2023
Introduction: Oral squamous cell carcinoma (OSCC) is the most prevalent malignancy of the oral cavity, representing approximately 90% of all oral cancers. This study was conducted to evaluate the frequency and clinicopathological characteristics of OSCC among patients referred to Amir al-Momenin…
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Artikel Jurnal
Immune checkpoint inhibitor-associated myocarditis in cancer patients: a systematic review of clinical presentation, management, and outcomes
Introduction: Immune checkpoint inhibitor-associated myocarditis (ICI-M) is a rare but life-threatening toxicity. This systematic review synthesizes the current evidence on the epidemiology, clinical presentation, diagnostic approaches, management strategies, and outcomes of ICI-M to guide clinical…
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Hepatitis B and hepatitis C viruses in the development of hepatocellular carcinoma and molecular mechanisms of carcinogenesis
Death from liver cancer spreads wide, mainly fueled by persistent hepatitis B or C infections. Not alike in origin, yet both viruses twist liver cell routines - genetically, operationally - to spark malignancy. One truth stands: differences matter, even if outcomes feel similar. HBV stores data in…
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Artikel Jurnal
Steroid induced exacerbation in kaposi sarcoma, a clinical paradox: a case report
Introduction: Kaposi sarcoma is uncommonly encountered in clinical practice. It is described as vascular malignancy associated with HHV-8 infection. It most commonly affects skin, but can also affect mucosal surfaces, lymphatics and visceral organs. In recent times, with availability of HAART and…
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Artikel Jurnal
Giant benign phyllodes tumor equal to size of patient’s abdomen: a case report
Introduction: Phyllodes tumor is a rare form of breast malignancy. Although the Phyllodes tumor rarely metastasizes, they can grow faster than any other breast tumor. Diagnosis and treatment are crucial, and surgery is the first line of action. Large tumors represent a surgical challenge because…
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The investigation of the impact of Bipolar Manic Depression (BMD) on the progression of diseases in patients with glioblastoma
Bipolar manic depression (BMD) affects 0.8–1.2% of the global population and is associated with a lifelong burden of mood instability, pro‑inflammatory immune profiles, and dysregulated stress‑hormone axes. Glioblastoma (GBM) remains the most lethal primary brain tumour, with a median survival of…
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Artikel Jurnal
Pola-R-CHP versus R-CHOP in newly diagnosed diffuse large B-cell lymphoma: a systematic review of efficacy, safety, and patient selection
Introduction: The combination of polatuzumab vedotin with rituximab, cyclophosphamide, doxorubicin, and prednisone (Pola-R-CHP) has emerged as a potential frontline therapy for diffuse large B-cell lymphoma (DLBCL). This systematic review synthesizes the current evidence comparing the efficacy and…
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Stem cells and cancer: recent updates in tumor biology, cancer stem cells, and targeted therapies
Cancer remains a significant health concern all over the world. Regardless of advancements in surgery, chemotherapy, radiotherapy, and targeted therapies, tumor recurrence and resistance against therapies remain significant challenges. There is increasing evidence suggesting a central role of…
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Efficacy and safety of immune checkpoint inhibitors versus chemotherapy in advanced non-small cell lung cancer: a systematic review of randomized controlled trials
Introduction: Immune checkpoint inhibitors (ICIs) have revolutionized the treatment landscape for advanced non-small cell lung cancer (NSCLC). This systematic review synthesizes the evidence from randomized controlled trials (RCTs) to evaluate the efficacy and safety of ICI-based therapies compared…
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Artikel Jurnal
Quercetin enhances radiosensitivity in T47D breast cancer cells: impact on DNA damage, clonogenic survival, and antioxidant defenses
Introduction: Radiotherapy resistance remains a significant challenge in breast cancer treatment. Quercetin, a natural flavonoid, has emerged as a potential radiosensitizer. This study examined its effects on hormone receptor-positive T47D breast cancer cells. Materials and methods: T47D cells were…
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The link between malignancy and arterial thrombotic events: a systematic review across cancer types
Introduction: A diagnosis of cancer is associated with an elevated risk of arterial thrombotic events (ATEs), including myocardial infarction (MI) and ischemic stroke. This systematic review synthesizes the current evidence on the epidemiology, risk factors, time-dependent risks, and outcomes of…
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Artikel Jurnal
Fibroadenoma and phyllodes tumor diagnosed in contralateral breasts: a rare case report
Introduction: Fibroadenomas and phyllodes tumors are fibroepithelial lesions of the breast that differ significantly in their clinical behavior, prognosis, and management. While fibroadenomas are common benign tumors in young women, phyllodes tumors are rare and can range from benign to malignant…
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The co-administration of quercetin and gallic acid nanocapsules exhibits a protective effect against aluminium chloride in the brain of animal model
Introduction: Aluminum (Al) is associated with the development of various neurological disorders, including Alzheimer's disease (AD), highlighting the need for materials with protective effects. This study investigated the protective effect of quercetin and gallic acid nanocapsules on brain damage…
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Artikel Jurnal
Practical application of stem cell therapy in retinoblastoma
Retinoblastoma (RB), recognized as the most prevalent intraocular malignancy in pediatric populations, continues to pose considerable therapeutic challenges due to its genetic etiology, tumor heterogeneity, and resistance to standard treatment modalities. Recent progress in stem cell biology has…
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Artikel Jurnal
Alzheimer’s disease and glioblastoma: a comprehensive review of epidemiological and translational medicine
Alzheimer's disease (AD), neuropsychiatric disorders, and glioblastoma represent distinct yet interconnected conditions characterized by overlapping molecular, cellular, and genetic mechanisms. Epidemiological studies reveal an inverse comorbidity between AD and glioblastoma, while psychiatric…
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Artikel Jurnal
Antihypertensive medications and hepatocellular carcinoma risk: a systematic review
Introduction: Emerging evidence suggests that antihypertensive medications may influence the risk, progression, and survival outcomes of hepatocellular carcinoma (HCC). However, findings across studies remain inconsistent. This systematic review aims to evaluate and synthesize current data on the…
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Artikel Jurnal
The Association between oral antihypertensive drug use and lung cancer risk in adults: a systematic review
Introduction: Hypertension is a widespread cardiovascular condition often managed with antihypertensive medications, including ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), calcium channel blockers (CCBs), and others. Emerging evidence suggests these medications may influence cancer…
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Artikel Jurnal
Metastatic carcinoma-ex pleomorphic adenoma of the pharynx with carotid space invasion: a rare case report
Introduction: Carcinoma ex pleomorphic adenoma (CXPA) is a rare, aggressive malignancy of the salivary glands that arises from a pre-existing pleomorphic adenoma. Although pleomorphic adenomas are benign, their potential for malignant transformation necessitates timely diagnosis and management…
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Artikel Jurnal
A case of ectopic decidual reaction of omentum masquerading as peritoneal carcinomatosis: a rare case report
Introduction: Omental deciduosis is a rare form of ectopic decidua characterized by the presence of decidual tissue outside the uterus. Although benign and self-limiting, its gross appearance may closely mimic intra-abdominal malignancy or infectious pathology, posing a diagnostic challenge. Case…