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Cardiovascular risk in hormone replacement therapy

Doris Barcellona

Bleeding, Thrombosis and Vascular Biology, Vol. 5 No. 1 · 2026 · Inggris · DOAJ Scopus

Hormone replacement therapy (HRT) effectively alleviates vasomotor symptoms related to menopause, but it can also raise the risk of cardiovascular disease. Several factors influence the likelihood of developing coronary artery disease or ischemic stroke, including a woman's age, the time since…

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Thrombophilia work-up and clinical outcomes in Indian patients with unprovoked venous and arterial thrombosis aged 18-50 years

Monisha Harimadhavan; Bharath Ram; Karthick R G dkk.

Bleeding, Thrombosis and Vascular Biology, Vol. 5 No. 1 · 2026 · Inggris · DOAJ Scopus

Background: The prevalence of thrombophilia in patients with unprovoked thrombotic events varies across populations, justifying the need for region-specific data to guide appropriate testing strategies. Methods: This study included patients aged 18-50 years presenting with unprovoked venous…

Pharmacokinetics of extended half-life albumin-fused factor IX and heterogeneous F9 variants in hemophilia B: a retrospective cohort study

Barbara Lunghi; Massimo Morfini; Silvia Linari dkk.

Bleeding, Thrombosis and Vascular Biology, Vol. 5 No. 1 · 2026 · Inggris · DOAJ Scopus

No information is available about the influence exerted by F9 variants on extended half-life (EHL)-recombinant factor IX (rFIX) pharmacokinetics (PK). Adult patients with severe HB (n=41), infused with EHL albumin-fused-rIX-FP, were investigated for key parameters, obtained by Non-Compartmental…

Hemophilia-free mind: a call to action

Tiziano Martini; Chiara Gorio; Cristina Dainese dkk.

Bleeding, Thrombosis and Vascular Biology, Vol. 5 No. 1 · 2026 · Inggris · DOAJ Scopus

Dear Editor, Over the last few decades, therapeutic goals for people with hemophilia (PwH) -particularly moderate and severe forms- have undergone a remarkable transformation...

Comments on “Low-dose aspirin for preventing intrauterine growth restriction and pre-eclampsia in sickle cell pregnancy in Nigeria (PIPSICKLE): a randomised controlled trial”

Sistiana Aiello; Ariela Benigni; Giuseppe Remuzzi

Bleeding, Thrombosis and Vascular Biology, Vol. 5 No. 1 · 2026 · Inggris · DOAJ Scopus

In the early 1970s, aspirin (acetylsalicylic acid) was shown to inhibit platelet aggregation by irreversibly acetylating platelet cyclooxygenase (COX), thereby suppressing the synthesis of its pro-aggregating product thromboxane A₂ (TxA₂)...

Development of a shared decision-making tool for gene therapy in hemophilia A in Italy

Giovanni Di Minno; Sarah Bigi; Serena Barello dkk.

Bleeding, Thrombosis and Vascular Biology, Vol. 5 No. 2 · 2026 · Inggris · DOAJ Scopus

Background: Gene therapy offers a transformative treatment option for hemophilia A (HA) by restoring endogenous factor VIII production. Shared decision-making (SDM) is a collaborative process that allows patients and clinicians to weigh the risks and benefits of complex treatment options such as…

Gian Franco Gensini: a memory by the Italian Society of Human Nutrition

Pasquale Strazzullo

Bleeding, Thrombosis and Vascular Biology, Vol. 5 No. 2 · 2026 · Inggris · DOAJ Scopus

Dear Editor, Anyone who has known Prof. Gian Franco Gensini and has had the opportunity to interact with him, in the professional field or even in social life, must have been fascinated by his forward-looking vision of the future and by his constructive optimism [...].

To P or not to P. That is the wrong question.

Augusto Di Castelnuovo; Giovanni de Gaetano

Bleeding, Thrombosis and Vascular Biology, Vol. 5 No. 2 · 2026 · Inggris · DOAJ Scopus

A few years ago, an article in the first issue of Bleeding, Thrombosis and Vascular Biology, argued that biomedical research should move beyond the mechanical use of the p-value. That message was not new, but it was timely. It remains timely today. The p-value is still often treated as a…

Beyond the usual workup: severe hypertriglyceridemia as a potential cause of cerebral venous thrombosis

Arnaud Lapostolle; Randa Khani-Bittar; Julie Mazoyer dkk.

Bleeding, Thrombosis and Vascular Biology, Vol. 5 No. 2 · 2026 · Inggris · DOAJ Scopus

Hypertriglyceridemia and cerebral venous thrombosis are well-recognized complications of asparaginase therapy for B-cell acute lymphoblastic leukemia. Hypertriglyceridemia has also been associated with an increased risk of thrombosis in conditions such as Behçet’s disease and has been implicated in…

The expanded universe of thrombin: a comprehensive review of its hemostasis-independent roles and structure-function relationships

Monica Sacco; Stefano Lancellotti; Antonietta Ferretti dkk.

Bleeding, Thrombosis and Vascular Biology, Vol. 5 No. 3 · 2026 · Inggris · DOAJ Scopus

Thrombin, the central protease of the coagulation cascade, has long been recognized for its essential role in hemostasis, converting fibrinogen to fibrin and activating platelets. However, a growing body of evidence over the past two decades has firmly established thrombin as a pluripotent mediator…

Lupus anticoagulant: a never-ending story. New insights from anti-prothrombin antibodies

Vittorio Pengo

Bleeding, Thrombosis and Vascular Biology, Vol. 5 No. 3 · 2026 · Inggris · DOAJ Scopus

Until recently, the lupus anticoagulant (LA) phenomenon was largely attributed to antibodies directed against β2-glycoprotein I (β2GPI). However, this explanation does not account for LA activity in patients with isolated LA, in whom anti-β2GPI antibodies are absent. Increasing evidence indicates…

Inflammation and hemostatic system: a selection of involved clinical disorders

Francesco Marongiu; Antonella Mameli; Silvia Marongiu dkk.

Bleeding, Thrombosis and Vascular Biology, Vol. 5 No. 3 · 2026 · Inggris · DOAJ Scopus

The role of the hemostatic system in host defense underscores the significant connection among coagulation, platelets, and inflammation. Both the hemostatic and the immune systems share a common ancestral origin. During infections, blood coagulation and platelet activation work in tandem with the…

Perioperative management of patients taking direct oral anticoagulants: challenges in high-bleed-risk surgery and neuraxial anesthesia

Maria P. Ntalouka; Eleni M. Arnaoutoglou; James D. Douketis

Bleeding, Thrombosis and Vascular Biology, Vol. 5 No. 3 · 2026 · Inggris · DOAJ Scopus

Perioperative direct oral anticoagulants (DOACs) management has been supported by guidelines, however there is still limited high quality data to inform best practices regarding the perioperative management of DOAC-treated patients who need a high-bleed-risk surgery, including those receiving any…

In memoriam of Prof. Armando D’Angelo (1952-2024)

Franco Piovella; Björn Dahlbäck; Raimondo De Cristofaro dkk.

Bleeding, Thrombosis and Vascular Biology, Vol. 5 No. 3 · 2026 · Inggris · DOAJ Scopus

This paper collected memories of Armando D’Angelo written by: Franco Piovella, Valerio De Stefano, Charles “Chuck” T. Esmon, Charles “Kurt” Mahan, Alex Spyropoulos, Hugo ten Cate, Stefanie Mahan, Bruce L. Davidson, Jim Morrissey, Raimondo De Cristofaro, Björn Dahlbäck, Francesco Bernardi.

A case of inadvertent overdose with argatroban in a 13-month-old toddler in the cardiac catheterization lab setting

Charles E. Mahan

Bleeding, Thrombosis and Vascular Biology, Vol. 5 No. 3 · 2026 · Inggris · DOAJ Scopus

A case-report is presented of a toddler who received an overdose of argatroban in the cardiac catheterization lab setting due to suspected heparin induced thrombocytopenia. This is the highest known overdose of argatroban in terms of dose-to-weight ratio. The overdose was treated and the patient…

Trypsin is as procoagulant as factor XIIa

Stephanie A. Smith; James H. Morrissey

Bleeding, Thrombosis and Vascular Biology, Vol. 5 No. 3 · 2026 · Inggris · DOAJ Scopus

To help shed light on the roles of the contact pathway of blood clotting, we quantified the relative procoagulant activities of each of the serine proteases of the clotting cascade. We added varying concentrations of the activated forms of different clotting proteases to normal human plasma and…

In this issue

Giovanni de Gaetano; Chiara Cerletti

Bleeding, Thrombosis and Vascular Biology, Vol. 5 No. 3 · 2026 · Inggris · DOAJ Scopus

During the XXVIII National Congress of the Italian Society for the Study of Thrombosis and Haemostasis (SISET) held in Rome, November 2024, in the context of a Session organized in memoriam of Armando D’Angelo, the Editor-in-Chief of BTVB proposed to prepare a dedicated issue in memory of Armando…

Development and implementation of a mathematical model for inpatient warfarin dosing: rationale and methods

Nikolaos Tsaftaridis; Mark Goldin; Kanta Ochani dkk.

Bleeding, Thrombosis and Vascular Biology, Vol. 5 No. 3 · 2026 · Inggris · DOAJ Scopus

Despite a narrow therapeutic range, need for frequent monitoring, and continuous dosing adjustment, vitamin K antagonists like warfarin remain widely prescribed worldwide owing to superiority over newer anticoagulants in key patient populations and low cost. Several models exist to guide warfarin…

Whole exome sequencing in a family with thromboangiitis obliterans

Barbara Lunghi; Dario Balestra; Nicole Ziliotto dkk.

Bleeding, Thrombosis and Vascular Biology, Vol. 5 No. 3 · 2026 · Inggris · DOAJ Scopus

Low-frequency candidates for susceptibility to thromboangiitis obliterans (TAO) were investigated by whole exome sequencing in a family with a young member with migrating thrombophlebitis, artery thrombosis, and ulcerations followed by below-knee amputation. Filtering among 193 candidates for…