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Clinical Cancer Bulletin
ISSN 2791-3937 · Springer Nature · 33 articles in the index
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Journal Article
Chinese expert consensus on the management of adverse events to HER2-targeted antibody–drug conjugates in digestive system cancers (2025 edition)
Abstract Digestive system cancers represent a group of malignancies with high global incidence and a particularly heavy disease burden in China. Among these, gastric cancer, colorectal cancer, and biliary tract cancer represent critical human epidermal growth factor receptor 2 (HER2)-positive…
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Journal Article
Chinese expert consensus on ultrasound-guided percutaneous lung needle biopsy (2025 Edition)
Abstract Ultrasound-guided percutaneous lung needle biopsy (US-PLNB) is a pivotal diagnostic technique for subpleural pulmonary lesions, offering significant advantages including real-time imaging, absence of ionizing radiation, and high procedural flexibility. A multidisciplinary expert panel was…
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Journal Article
Chinese expert consensus on robotic surgery for colorectal cancer (2025 edition)
Abstract Robot surgery is an important trend in contemporary colorectal cancer surgical treatment. The Robotic Surgery Group, Colorectal Cancer Committee of Chinese Medical Doctor Association organized experts in relevant fields across the country to update and revise the application standards of…
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Journal Article
Computational stratification and engineering framework of the PDCD1/CD2 immune axis in triple-negative breast cancer
Abstract Purpose Triple-negative breast cancer (TNBC) is a high-risk molecular subtype defined by absence of estrogen receptors, progesterone receptors, and human epidermal growth factor receptor 2 (HER2) overexpression. Immune checkpoint blockade (ICB) benefits only 20% to 40% of patients, with T…
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Journal Article
Targeting HER-2 pathway in presence of cardiac dysfunction: the walk on a tight rope
Abstract Human epidermal growth factor receptor 2 (HER2) is overexpressed in 25%–30% of breast cancer cases and was previously correlated with inferior outcomes. HER2 amplification in breast cancer was discovered in the 1980’s and the monoclonal antibody has largely been available for clinical use…
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Journal Article
Global research status and trends in the AI-driven anticancer drug design: a bibliometric analysis of 2011–2025
Abstract Purpose To provide a comprehensive overview of research in AI-driven anticancer drug design and to recommend future research directions for both researchers and clinicians. Methods A thorough literature search was conducted across the Web of Science Core Collection databases. Analysis was…
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Journal Article
Exploring mitochondrial central dogma in cancer from a metabolic perspective
Abstract Mitochondria are metabolic hubs that house their own genomes (mitochondrial DNA [mtDNA]), which encode components of the oxidative phosphorylation (OXPHOS) machinery. The mitochondrial central dogma not only governs compartmentalised metabolism but also intensively intertwines with…
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Journal Article
Patient-derived tumor organoid co-culture systems as translational platforms for cancer immunotherapy and precision oncology
Abstract The tumor microenvironment (TME) is a dynamic and immunosuppressive niche that critically governs cancer progression, immune evasion, and therapeutic resistance. Accurately modeling tumor–immune interactions in vitro is therefore essential for advancing our understanding of cancer biology…
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Journal Article
A heterogeneous multimodal ensemble framework for multi-omics breast cancer prognosis
Abstract Purpose Accurate breast cancer prognosis remains a major challenge in precision oncology due to tumor heterogeneity and the complexity of integrating high-dimensional multi-omics data. Although multimodal learning approaches have improved predictive performance by combining clinical and…
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Journal Article
The CCL2/CCR2 axis in irradiated tumors: orchestrating immune recruitment and microenvironment remodeling
Abstract Radiotherapy (RT) is a cornerstone of solid tumor treatment, but its capacity to reshape the tumor microenvironment (TME) also has a less favorable consequences: acquired radioresistance, which can limit durable systemic antitumor immunity. Within this remodeling process, the CCL2/CCR2…
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Journal Article
Radiotherapy-induced immunity is real but incomplete: nano-immunoadjuvants as immune amplifiers in radioimmunotherapy
Abstract Radiotherapy (RT) can initiate antitumor immunity through immunogenic cell death, tumor-associated antigen release, and innate immune engagement, but these responses are often too weak and transient to achieve durable systemic tumor control. This perspective identifies insufficient immune…
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Journal Article
Clinical diagnosis and treatment recommendations for immune checkpoint inhibitor-associated myocarditis (2026 edition)
Abstract Immune checkpoint inhibitors (ICIs) deliver prominent anti-tumor efficacy across multiple malignancies, yet ICI-associated myocarditis represents a life-threatening adverse event requiring standardized management. Updated from the 2022 version, these recommendations integrate up-to-date…
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Journal Article
Comparative efficacy and safety of postoperative adjuvant therapies after curative resection for hepatocellular carcinoma: a network meta-analysis
Abstract Purpose Hepatocellular carcinoma (HCC) has a high risk of recurrence even after curative-intent hepatic resection. Although several postoperative adjuvant therapies have been investigated, the optimal strategy remains uncertain because direct head-to-head comparisons are limited. This…
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Journal Article
Chinese guidelines for the diagnosis and comprehensive treatment of colorectal liver metastasis (2025 Edition)
Abstract The liver is the primary target organ for hematogenous metastasis of colorectal cancer, and colorectal cancer liver metastasis is one of the key and challenging aspects in its treatment. In order to improve the diagnosis and comprehensive treatment of colorectal cancer liver metastasis…
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Journal Article
Causal relationships between cerebral cortical architecture and blood cancers: the disease spectrum is different because the brains look different
Abstract Purpose Little is known about how the brain regulates extracerebral tumors. There is a significant difference in the incidence of hematologic maligancies between Han Chinese and European/American populations, with the most pronounced difference being more than 8–10 fold for multiple…
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Journal Article
Conditional reprogramming in eyelid tumors: bridging the model gap in meibomian gland carcinoma
Abstract Eyelid tumors, particularly sebaceous carcinoma and meibomian gland carcinoma (MGC), are rare but highly aggressive malignancies characterized by diagnostic difficulty, early dissemination, and limited therapeutic options. Progress in understanding their biology and developing effective…
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Journal Article
Dual role of interleukin-2 in tumor-infiltrating lymphocyte therapy
Abstract Tumor-infiltrating lymphocyte (TIL) therapy has become a promising immunotherapy for the treatment of solid tumors and has shown substantial therapeutic potential in recent years, offering new options for patients with cancer. Despite its encouraging clinical outcomes, TIL therapy…
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Journal Article
Lineage infidelity in small-cell lung cancer: driving subtype transitions and acquired therapeutic vulnerabilities
Abstract Small-cell lung cancer (SCLC) has long been characterized by its aggressive clinical course and a deceptive initial sensitivity to chemotherapy that almost invariably yields to recalcitrant disease. Recent genomic and transcriptomic profiling has dismantled the historical view of SCLC as a…