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Pharmacoepidemiology
Scopus
ISSN 2813-0618 · MDPI AG · 123 artikel di indeks
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Artikel Jurnal Teks lengkap
The Burden of Disease of Medication Errors: Analysis in ADR Caused Emergency Visits
Background: Medication errors (MEs) are an important cause of preventable harm but remain insufficiently quantified in emergency care. This study assessed the frequency, characteristics, and clinical impact of MEs among adverse drug reaction (ADR)–related emergency department (ED) admissions in…
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Perceived Credibility and Information-Verification Behavior in Relation to Self-Medication Influenced by Health Information on Social Media: A Cross-Sectional Study
Background/Objectives: Social media has become a major source of health information worldwide; however, how users appraise the credibility of online health information and verify its reliability may be associated with medication-related decision-making. This study examined the associations of…
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Clinical and Medication-Related Factors Associated with Adverse Renal Outcomes in Advanced Chronic Kidney Disease Patients Treated with Empagliflozin: A Real-World Study in Thailand
Background: Sodium-glucose cotransporter-2 (SGLT2) inhibitors have been shown to reduce the rate of chronic kidney disease (CKD) progression and provide cardioprotective benefits beyond glycemic control. However, evidence regarding their effects on kidney disease progression in advanced CKD…
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Exploring the Medical Prescription of Cannabis sp.-Derived Products in Brazil: A National Cross-Sectional Survey
Background/Objectives: Patient access to cannabinoid-based therapies in Brazil has expanded with the availability of regulated Cannabis-derived products (CDPs). This study explored CDP prescribing practices among Brazilian physicians. Methods: Between September 2024 and March 2025, a national…
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Shifts Toward Direct Oral Anticoagulants in Ambulatory Care: Utilization Trends and SARIMA Forecasts
Background: Anticoagulant treatment is central to the prevention and management of thromboembolic cardiovascular disease, and contemporary practice has increasingly shifted toward direct oral anticoagulants. Objectives: To quantify ambulatory anticoagulant utilization trends in Greece during 2018…
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Primary Non-Adherence to Electronic Prescriptions in Lithuania, 2018–2024: Nationwide Prevalence, Factors, and Regional Variation
Background/Objectives: Primary non-adherence occurs when a prescribed medicine is never collected, preventing treatment from the beginning. Despite non-adherence being a widespread problem, most evidence comes from Western European and North American systems, and the Baltic region has rarely been…
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Report-Level Comparator-Definition Sensitivity in FAERS Cardiometabolic Disproportionality Analysis: A Long-Acting Cabotegravir/Rilpivirine HIV Pharmacovigilance Case Study
Background/Objectives: Comparator selection can change disproportionality findings when multidrug therapies are represented by report-level listings rather than verified treatment histories. We evaluated a proxy-comparator framework for cardiometabolic reporting with long-acting…
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Serum Prolactin and Bone Mineral Density in Women with Schizophrenia Receiving Prolactin-Raising Antipsychotics: A Cross-Sectional Study
Background/Objectives: Antipsychotic-induced hyperprolactinemia may adversely affect skeletal health through suppression of the hypothalamic–pituitary–gonadal axis; however, the independent association between circulating prolactin and bone mineral density (BMD) remains uncertain. Methods: This…
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Virologic Outcomes of Predominantly Tenofovir-Based First-Line Antiretroviral Therapy Among Treatment-Naïve HIV Patients in Davao City, Philippines
Background/Objectives: Tenofovir disoproxil fumarate (TDF)-containing regimens remain the cornerstone of first-line antiretroviral therapy (ART) in many low- and middle-income countries. However, concerns regarding treatment failure and antiretroviral resistance highlight the need to evaluate the…
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Reported Private-Sector Dispensing Trends of Methylphenidate in Costa Rica, 2017–2024: An Ecological Drug-Utilization Study
Background/Objectives: Methylphenidate is widely used for attention-deficit/hyperactivity disorder and is available in immediate-release (IR) and extended-release (XR) formulations. Long-term reported private-sector dispensing data from Costa Rica remain limited. Because methylphenidate is a…
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An Overview of Antibiotic Consumption in Croatian Counties, 2017–2024: Temporal and Geographic Patterns Before, During, and After the COVID-19 Pandemic
Background/Objectives: Croatia is among the European countries with moderately high antibiotic consumption and correspondingly elevated antimicrobial resistance (AMR) rates. National-level surveillance, however, masks substantial county-level heterogeneity that is relevant for targeted stewardship…
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Influenza Vaccine Effectiveness Among Italian Adults: A Test-Negative Case–Control Study from an Italian Southern Province During the 2024/25 Winter Season
Background: In Italy, seasonal flu vaccination was recommended for all children aged 6 months to 6 years, all adults aged ≥60 years and specific at-risk groups. Influenza vac-cine effectiveness (IVE) varies from season to season. It can be related to several factors: possible mismatches between…
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Comparison of Two Triple Therapy Regimens for Helicobacter pylori Eradication in Patients with Dyspepsia: A Retrospective Study from Primary Care
Background and Objective: Helicobacter pylori infection remains a major cause of chronic gastritis, dyspepsia, and peptic ulcer disease worldwide. Increasing antibiotic resistance, particularly to clarithromycin, has reduced the effectiveness of standard eradication therapies. The aim of this study…
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Use of the Zipf–Mandelbrot Law in Modelling US FDA Adverse Reactions
Background: The purpose of this preliminary study was to evaluate the use of the Zipf–Mandelbrot (ZM) law to mathematically model the percentage occurrence of adverse drug reactions (ADRs), as a function of rank, reported to the United States Food and Drug Administration Adverse Event Monitoring…
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Assessment of Inappropriate Omeprazole Prescribing, Associated Factors and Financial Impact in the Outpatient Department of a General Hospital in Thailand
Background: Proton pump inhibitors (PPIs) are widely used for the treatment of gastrointestinal (GI) disorders. Omeprazole is one of the most commonly prescribed PPIs in Thailand. However, it is frequently overprescribed in hospital settings, increasing the risk of adverse effects. Moreover, such…
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Digital Pharmacoepidemiology of Glucagon-like Peptide-1 Receptor Agonists in Russia: A Retrospective Search Query Analysis (2018–2026)
Background: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) and GLP-1/glucose-dependent insulinotropic polypeptide (GIP) dual agonists have revolutionized the treatment of type 2 diabetes and obesity. The rapid growth in public interest, off-label use, and the emergence of counterfeit drugs…
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Signal Characterization of Insulin Glargine Product Groups in the United States Food and Drug Administration Adverse Event Reporting System
Background/Objectives: We described adverse event reporting patterns for insulin glargine marketed as 100 units/mL (Lantus), 300 units/mL (Toujeo), and 100 units/mL biosimilars (Basaglar/Semglee). Methods: We analyzed Food and Drug Administration Adverse Event Reporting System (FAERS) reports…
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Medication Adherence and Its Discordance with Glycemic Control in Type 2 Diabetes: A Real-World Study in Primary Health Care in the Brazilian Amazon
Background/Objectives: Medication adherence is a critical determinant of therapeutic outcomes in type 2 diabetes mellitus (T2DM); however, its relationship with glycemic control remains inconsistent, particularly in real-world and socially vulnerable settings. This study aimed to evaluate…
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Medication Discrepancies at Hospital Discharge Among Adults with and Without Mental Health Conditions: A Retrospective Cohort Study
Background/Objectives: Medication discrepancies at hospital discharge are common and may contribute to adverse drug events and avoidable healthcare use. Patients with mental health conditions may be at increased risk because of greater clinical complexity, polypharmacy, and fragmented care, but…
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Determinants and Temporal Trends of Inappropriate Azithromycin Use in Hospitalized Adults with COVID-19: A Retrospective Pharmacoepidemiologic Cohort Study
Background: The COVID-19 pandemic was associated with extensive empirical antibiotic exposure despite the predominantly viral etiology of the disease. Evaluating patterns of azithromycin use, prescribing determinants, and appropriateness provides insight into real-world antibiotic use under…