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Frontiers in Transplantation
Scopus
ISSN 2813-2440 · Frontiers Media S.A. · 325 artikel di indeks
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Artikel Jurnal
Does sex matter? Longitudinal course and predictors of knowledge about immunosuppressant medication in patients after kidney transplantation: a KTx360° substudy
BackgroundTo ensure long term graft and patient survival after kidney transplantation, the correct intake of the immunosuppressive medication is mandatory. To correctly administer the medication, specific knowledge is required. While the significance of adherence has been recognized by many, the…
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Artikel Jurnal
Sir Roy Calne: a renaissance man of modern medicine
It is a challenging task to encapsulate the prolific life and accomplishments of Sir Roy Calne, a unique individual and pioneer who transformed the impossible into clinical reality, forging a new era of organ transplantation. In the annals of medical history, few figures embody the intersection of…
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Artikel Jurnal
Liver transplant and impact on cerebral autoregulation: a systematic scoping review
BackgroundCerebral autoregulation (CA)—the brain's ability to maintain stable cerebral blood flow (CBF) despite changes in mean arterial pressure (MAP)—may be disrupted during orthotopic liver transplantation (OLT) due to profound metabolic, inflammatory, and hemodynamic alterations. Such…
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Artikel Jurnal
Case Report: Bezoar in allograft duodenum—rare cause of bowel obstruction 13 years post-pancreas transplant
Small bowel obstruction (SBO) following pancreatic transplantation is a recognized complication, most often caused by adhesive disease and hernias. To our knowledge, a pancreatic allograft duodenal bezoar has not been previously described as a cause of obstruction. A 69-year-old female presented to…
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Artikel Jurnal
Challenges and perspectives in xenoliver research: lessons from decedent and primate models
Liver xenotransplantation is a potential strategy to address the shortage of donor livers, either as a temporary bridge to allotransplantation, bridge to native liver recovery, or destination therapy. Advances in genetic engineering and immunosuppression have enabled liver xenografts to evade…
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Artikel Jurnal
100 most-cited publications in vascularized composite allotransplantation
BackgroundCitation analysis is a useful bibliometric tool to identify impactful publications and trace the evolution of a specialty or a technique. In the past three decades, the research on vascularized composite allotransplantation (VCA) has grown exponentially but very few studies have examined…
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24-hour ex vivo perfusion of vascularized composite allografts in a large animal total limb model
BackgroundStatic cold storage (SCS) at 4 °C remains the standard for preserving vascularized composite allotransplants (VCA) but limits viability to approximately 6 h. Ex-vivo perfusion offers a promising alternative. This study presents a 24-h sub-normothermic perfusion protocol in a swine…
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Artikel Jurnal
Machine perfusion for liver transplantation: opportunities and challenges for the next generation of transplant surgeons
Machine perfusion is reshaping liver transplantation by turning preservation from passive storage into an active, physiologic intervention. This review synthesizes randomized and real-world evidence on hypothermic oxygenated and normothermic approaches and translates these data into practical…
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Innovative approaches targeting innate immune cells to promote organ transplant tolerance
Achieving long-term allograft survival while minimizing systemic immunosuppression (IS) remains a critical unmet need in transplantation. While adaptive immunity has traditionally been the primary focus of IS therapy, innate immune cells—that include neutrophils, monocytes, macrophages, dendritic…
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Artikel Jurnal
The risk of kidney transplant graft loss in sensitized vs. unsensitized patients is modified by prior transplant status
BackgroundA prior kidney transplant (KT) has been associated with an increased risk of graft loss following repeat transplantation. This study examined the risk of adverse posttransplant outcomes between patients with and without a prior transplant, depending on sensitization status.MethodsWe used…
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Artikel Jurnal
Double whammy: increased severe primary graft dysfunction after prolonged warm ischemia and inadequate oxygen delivery during heart transplant
ObjectiveThis exploratory study examined the relationship between oxygen delivery index (DO2i) during DCD heart transplant (HT), warm ischemic time, and posttransplant outcomes.MethodsAll DCD HT between 10/2021 and 12/2024 using normothermic regional perfusion (NRP) at our institution were…
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Artikel Jurnal
Liver transplantation in patients with history of extra-hepatic malignancies
IntroductionIncreasing use of solid organ transplantation [SOT] has coincided with increasing cancer survivorship. Consensus statements exist for SOT in patients with pre-transplant malignancy [PTM]. Yet, most outcomes have been reported in heart and kidney transplant. This paper addresses the…
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Artikel Jurnal
Systematic review of emerging technologies in vascularized composite allotransplantation
Vascularized composite allotransplantation (VCA) enables functional reconstruction for patients with extensive tissue defects, but has obstacles such as immune rejection, lifelong immunosuppression, and systems-level barriers that limit widespread adoption. VCA has rapidly evolved through novel…
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Variability in clinical triggers for organ donation referrals
In organ transplantation, regulatory efforts have mainly targeted Organ Procurement Organizations (OPOs) and transplant centers, while donor hospitals—crucial to the donation process—have remained under-examined. As the first point of contact for potential donors, these hospitals lack standardized…
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Artikel Jurnal
Impaired graft survival in kidney transplants from expanded criteria donors with HLA-DR mismatch
Human leukocyte antigen (HLA)-DR mismatches are known to increase the risk of graft rejection following kidney transplantation (KT). Especially in KT using grafts of lower quality from expanded criteria donors (ECD), the immune response plays a critical role. Therefore, the aim of this study was to…
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Artikel Jurnal
Microbiota management: a perspective for kidney transplant patients
Chronic kidney disease (CKD) is recognized as one of the most significant public health issues globally, with approximately 40% of patients progressing to end-stage kidney disease (ESKD). Transplantation remains the most indicated option for many patients with ESKD; however, these individuals…
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Artikel Jurnal
Standardized evaluation protocols for deceased and living liver donors: a practical framework for emerging liver transplant programs
BackgroundLiver transplantation (LT) remains the definitive therapy for end-stage liver disease. However, significant variability in infrastructure, policy, and clinical practice continues to influence the implementation of deceased donor (DDLT) and living donor liver transplantation (LDLT)…
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Artikel Jurnal
Mechanisms inducing differentiation of adult islet progenitor-like cells into functional islet-like organoids
IntroductionAdult pancreatic tissue contains cell populations with latent regenerative potential, but the processes governing their expansion and differentiation into endocrine lineages remain unclear.MethodsAdult human pancreatic cells obtained from donor tissue were isolated and expanded and…
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Artikel Jurnal
Neu5Gc and beyond: sialylation at the innate immune and thromboinflammatory interface of xenotransplantation
Recent advances in genetic engineering have substantially reduced the major carbohydrate barriers to pig-to-human xenotransplantation. Deletion of GGTA1, CMAH, and B4GALNT2 decreases αGal, Neu5Gc, and B4GALNT2-dependent Sda-like xenoantigens and thereby attenuates preformed antibody binding and…