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Frontiers in Dementia
Scopus
ISSN 2813-3919 · Frontiers Media S.A. · 177 artikel di indeks
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An integrative neurogenomics workflow for precision medicine in neurodegenerative disorders
Neurodegenerative diseases represent an expanding global health challenge, with rapidly increasing prevalence and substantial economic impact. The therapeutic clinical approach continues to seek solutions through pharmacological means—such as inhibitors and antibodies—which, while sometimes…
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Microglial activation is raised in preclinical Alzheimer’s disease and associated with covert memory impairment
BackgroundAlzheimer’s disease (AD) is a continuum between normal health and dementia with a long preclinical phase, during which AD pathologies start to emerge, but where there are not yet any overt symptoms. The hallmark pathologies of AD are extracellular β-amyloid (Aβ) plaques and intra-neuronal…
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Accuracy of the revised Addenbrooke Cognitive Examination (ACE-R) and Mini-Mental (MMSE) in a Quilombola community with low education attainment: results of a cross-sectional study
BackgroundIlliteracy may overestimate screening test interpretation for older adults with suspected cognitive decline. In rural areas of Brazil, the illiteracy rate and the lack of valid cognitive instruments may postpone the diagnosis of cognitive disorders.ObjectiveTo determine the diagnostic…
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Cognitive decline in U.S. military veterans: risk factors and clinical implications
Military veterans have higher aggregate prevalence of risk factors for cognitive decline than non-veterans. This includes risk factors like diabetes, chronic pain, smoking, depression, and more. The disparity in prevalences is due in part to the unique experiences and exposures of their military…
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Amyloid-β acute exposition affects the CA1 hippocampal network activity and its topological organization, evaluated with multielectrode arrays
IntroductionNeuronal networks enable brain’s information processing through a well-coordinated activity. Disruptions in this activity can impair key brain functions such as synaptic plasticity and long-term memory. Such dysfunctions are relevant to the cognitive deterioration in Alzheimer’s disease…
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Clinical, social, molecular, and genetic predictors of cognitive resilience in long-living adults without dementia
BackgroundLong-living adults often maintain cognitive function despite neuropathological changes, which is often attributed to cognitive resilience (CR)—a combined effect of cognitive and cerebral reserves. CR is influenced by genetic, clinical, sociodemographic, and environmental factors.Materials…
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Case Report: Interdisciplinary approach to managing behavioural and psychological symptoms of dementia and delirium in acute care
Behavioural and Psychological Symptoms of Dementia (BPSD) and delirium are common in acute hospital settings. Although non-pharmacological approaches are recommended as first-line interventions, BPSD and delirium are still often managed with physical restraints and psychotropic medications, which…
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Dementia and hearing loss: from risk to mechanisms and management
Hearing loss in midlife is an important and potentially modifiable risk factor for the development of dementia. Research examining the association between dementia and hearing loss has expanded rapidly; however, evidence for the mechanisms linking the two conditions is inconclusive, limiting the…
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From mild behavioral impairment-checklist (MBI-C) to MBI-distress (MBI-D): a paired assessment and clinical correlates of domain-specific caregiver distress in MCI due to AD
BackgroundMild behavioral impairment (MBI) captures later-life onset neuropsychiatric symptoms (NPS) that may herald neurodegeneration. The emotional impact of these early behavioral changes on caregivers is under-measured in pre-dementia care.ObjectiveTo develop a brief, domain-aligned caregiver…
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Care challenges related to lack of awareness in people with dementia
IntroductionPerson-centered care can be difficult to provide where people with dementia lack awareness of dementia-related changes. They may appear reluctant to discuss changes or unable to recognize care needs. Lack of awareness can contribute to worse outcomes for people with dementia and…
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Expectations for a co-designed virtual immersive program for older adults with dementia in long-term care: a qualitative study with residents, family, and staff
IntroductionVirtual immersive programs (VIP) have been found as a recreational medium with positive impacts on the quality of life for older adults living with dementia in long-term care (LTC). While studies have explored the adoption of a VIP in LTC and suggested the need for tailored programs…
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The 2024 NIA-AA biological definition of Alzheimer’s disease: linking biomarkers to clinical practice
The 2024 National Institute on Aging–Alzheimer’s Association (NIA-AA) criteria establish a biological definition of Alzheimer’s disease (AD), marking a pivotal step toward linking research biomarkers with clinical practice. This review traces the evolution of AD diagnostic frameworks from the 1984…
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New perspectives on peer support in an online intervention for family carers of people living with dementia—evidence from an Irish NGO
IntroductionThe rising prevalence of dementia globally and in Ireland has intensified the need for effective support for family carers, who provide the majority of care for people living with dementia. This study examines an established education intervention called Home Based Care–Home Based…
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Use of the Roadmap positive activity app in daily life among dementia caregivers: evidence of feasibility and acceptability
BackgroundDementia caregivers often report poor mental health, which has implications for the quality of care, as well as care recipient well-being. Thus, it is imperative to identify modifiable factors that influence caregiver mental health and can be targeted through personalized…
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Development of a multimodal health education module for dementia prevention in at-risk rural Indian elders: a SMRUTHI INDIA initiative
IntroductionSMRUTHI-India (Strategic Multimodal Intervention in at-risk Elderly Indians for Prevention of Dementia), was initiated across rural India to establish a cohort of at-risk elderly for primary dementia prevention. Dementia prevalence being 7.4% and higher rates in rural areas, culturally…
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Equity-centered dementia prevention: lessons from a community-embedded intergenerational model
Dementia prevention requires policies that address upstream, modifiable risk factors—particularly loneliness, depressed mood, and low social participation—which disproportionately affect linguistically diverse and historically marginalized communities. This Perspective argues that linguistic…
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Leveraging artificial intelligence for analysis of the gut microbiome for dementia diagnosis: a scoping review and discussion
BackgroundDementia, a multifactorial disease with progressive cognitive decline, has been linked to imbalances in the gut-brain axis. Emerging artificial intelligence tools have augmented the identification of several gastrointestinal biomarkers for differential dementia detection and severity, but…
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From community to policy: a frontline model for dementia assessment and brain health
Globally, dementia prevalence is projected to rise from approximately 55 million people in 2025 to 139 million by 2050. In Ontario, prevalence is estimated to reach 756,100 people by 2050—an increase of 202% since 2020—placing increasing strain on care partners, families, and health systems…