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Frontiers in Cell Death
ISSN 2813-5563 · Frontiers Media S.A. · 31 artikel di indeks
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Artikel Jurnal
Hazard identification and the harmful effects of organophosphates and carbamates in bioethical models: a review
Pesticides are an emerging category of contaminants employed in agriculture or for domestic use. Among them, anti-cholinesterase insecticides are the most extensively applied. These are neurotoxic compounds released into the environment in an estimated millions of tons per year, posing serious…
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Artikel Jurnal
Thirty years of reaper: lessons learned from programmed cell death in Drosophila
April 2024 marked the 30-year anniversary of the publication of reaper, the first description of a Drosophila cell death gene. This discovery established the foundation for modern apoptosis research in Drosophila and fundamentally reshaped studies on programmed cell death (PCD). This review…
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Non-canonical regulated cell death and epigenetic mechanisms in the nervous system
Classical apoptosis alone does not sufficiently elucidate neuronal loss in the developing, aging, and pathological nervous system. Growing data show that neurons and glial cells, under different physiological or pathological conditions, undergo multiple non-canonical regulated cell death (RCD)…
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Synaptic deposition of lysophospholipids at stresses - risk of the regional lipotoxicity for brain diseases
Synapses are ‘double-edged swords’, being appropriate for the quick transmission of impulses in one hand, but vulnerable to the oxidative stress in another hand. When the presynaptic terminals convey neurotransmission by altering structure of lipid molecules in response to physiological stimuli…
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Artikel Jurnal
At the nucleus of neuronal health: Drosophila insights into LaminB-dependent homeostasis in aging and cell death
Brain neurons play a crucial role to maintain organism health in response to macro/micro-environmental biophysical and biochemical cues, and their dysfunction and death drive aging and diseases. However, cellular mechanisms controlling neuronal health are incompletely understood. Drosophila has…
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Artikel Jurnal
Regulated cell death in the nervous system: a framework for execution diversity and spatially restricted degeneration
Regulated cell death (RCD) encompasses genetically encoded and pharmacologically modifiable pathways that govern cellular demise. In the nervous system, RCD assumes unique biological and clinical relevance due to neurons’ post-mitotic status, the functional integration of neural circuits, and the…
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Artikel Jurnal
Decoding drug resistance and apoptosis in biliary tract cancers using 3D tumor models
BackgroundBiliary Tract Cancers (BTCs), including cholangiocarcinoma and gallbladder cancer, are aggressive malignancies characterized by late diagnosis, high mortality, and intrinsic resistance to standard chemotherapeutic regimens like gemcitabine and cisplatin. A critical barrier to improving…
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Leveraging ZBP1 signaling for cancer immunotherapy
Immune checkpoint inhibitors (ICIs) have transformed cancer care, yet durable responses remain limited in a majority of patients. This is particularly true of immunologically cold tumors, which are characterized by insufficient T-cell infiltration, low antigenicity, impaired adjuvanticity, and an…
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Artikel Jurnal
Challenges in drug efficacy and toxicity screening with 3D bioprinted melanoma models
Melanoma, an aggressive form of skin cancer, poses a significant public health challenge due to its metastatic potential, drug resistance and increasing prevalence. The development of three-dimensional (3D) bioprinted melanoma models has shown promise in providing a more cellular and biochemical…
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The lysosome as a central executioner: orchestrating multiple modalities of programmed cell death
Lysosomes have emerged as key signaling hubs that dictate cell fate, extending far beyond their traditional degradative functions. Central to this role is the integrity of the lysosomal membrane, which serves as a key mechanism through which diverse stress signals are converted into programmed cell…
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Lysosomal membrane-permeabilization (LMP) and -rupture (LMR) are distinct for cell death
Lysosome is crucial for maintaining cellular homeostasis, but disintegrity of its limiting membrane affects the cell death fate. From 1972 to 1999, via the cytochemistry of cultured cells which were exposed to stresses, Brunk et al. defined lysosomal membrane permeabilization (LMP) as leakage…
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Artikel Jurnal
C/EBPβ deficiency enhances keratinocyte apoptosis after UVB-induced DNA damage via regulation of the type I IFN and TNF responses
The epidermis is routinely subjected to DNA damage induced by ultraviolet B (UVB) solar radiation. In addition to activating canonical DNA damage responses such as cycle cell checkpoints and DNA repair, UVB-induced DNA damage can also activate additional signaling pathways including inflammatory…
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Copper-induced cell death mechanisms and their role in the tumor microenvironment
Copper is an essential cofactor for all organisms. However, it can become toxic if its concentration rises above a specific level. This level is controlled by evolutionary conserved homeostatic mechanisms. Recently, a new type of cell death called cuproptosis has been found. The process represents…
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Sacrificing cells of the cyst: non-apoptotic cell death in germline cysts via acidification
Cell death shapes multicellular organism development and sustains tissue and organ homeostasis. Great progress has been made in understanding the breadth of physiological and biochemical diversity in cell death and clearance pathways, which play vital roles in organismal development and health…
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Expression of two histone H4 epigenetic modifications (lysine 12 acetylation and lysine 20 trimethylation), and the senescence marker lamin B1 in the postnatal, adult, and old mouse brain
Aging is a complex biological process characterized by gradual cellular and molecular changes contributing to cognitive decline and neurodegeneration. Histone alterations regulate gene expression, chromatin organization, and neuronal function. Additionally, nuclear architecture undergoes…
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Artikel Jurnal
Exploring sugar-induced cell death in yeast: implications for diabetes and cancer research
When yeast cells are transferred to water only, they remain viable for several days. However, when transferred to water with glucose, there is a rapid loss of viability. This phenomenon is termed Sugar-Induced Cell Death (SICD). In addition to glucose, SICD can be induced by an array of different…
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Glycans on death receptors as sweet markers and signaling checkpoints
Apoptosis is a form of programmed cell death that eliminates excessive and damaged cells. It can be conducted by two ways: the extrinsic and the intrinsic (mitochondrial) pathways. The extrinsic death pathway is triggered by activation of the death receptors (DRs), while the intrinsic pathway is…
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Artikel Jurnal
Regulation of pyroptosis by NF-κB signaling
Pyroptosis is a form of proinflammatory cell death characterized by inflammasome activation, pore formation, and the release of pro-inflammatory cytokines such as interleukin-1β (IL-1β) and IL-18 upon cell rupture. Nuclear factor-κB (NF-κB), a prototypical pro-inflammatory transcription factor…