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Biomolecules & Biomedicine
Scopus
ISSN 2831-0896 · Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina · 1.630 artikel di indeks
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MTX pathway gene variants, erythrocyte methotrexate polyglutamates, and treatment outcomes in rheumatoid arthritis
Rheumatoid arthritis (RA) exhibits significant inter-patient variability in response to and toxicity from methotrexate (MTX). The clinical utility of erythrocyte methotrexate polyglutamates (MTXPGs) and MTX-pathway pharmacogenetics remains uncertain. This study investigates the relationships…
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Early childhood caries and type 1 diabetes mellitus – Evidence on primary teeth and oral health: A systematic review
Early childhood caries (ECC) among children with type 1 diabetes mellitus (T1D) remains poorly characterized in the primary dentition (≤71 months), despite frequent reports of salivary and periodontal alterations that could plausibly increase caries susceptibility. This systematic review aimed to…
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DYSF gene variant spectrum in Arab populations across eight countries: A systematic review
Dysferlinopathies are a subset of autosomal recessive muscular dystrophies resulting from pathogenic variants in the dysferlin (DYSF) gene. The prevalence of dysferlinopathies remains inadequately defined. This review aims to elucidate the mutational spectrum of DYSF in Arab populations. A…
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Pre-analytical storage effects on ALU- and LINE1-derived cell-free DNA biomarkers in whole blood and plasma
Cell-free DNA (cfDNA) biomarkers derived from Arthrobacter luteus (ALU) repeats and long interspersed nuclear elements 1 (LINE1) — including ALU-115, ALU-247, LINE1-97, and LINE1-266 concentrations, as well as the integrity ratios ALU-247/115 and LINE1-266/97 — are commonly utilized to assess cfDNA…
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Stem cell–based therapies for inherited retinal diseases – Translational advances and clinical evidence: A review
Inherited retinal diseases (IRDs) represent a genetically diverse group of disorders that result in the progressive degeneration of photoreceptors and/or retinal pigment epithelium (RPE), ultimately leading to significant vision loss and diminished quality of life. Symptoms vary widely…
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Preprocedural systemic immune-inflammation index predicts atrial fibrillation recurrence after catheter ablation: A systematic review and meta-analysis
Inflammation plays a significant role in the pathophysiology of atrial fibrillation (AF) and may affect the likelihood of AF recurrence following catheter ablation. The systemic immune-inflammation index (SII), calculated from circulating neutrophils, lymphocytes, and platelets, has emerged as a…
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Digoxin attenuates LPS-induced acute lung injury in mice via NF-κB and HIF-1α inhibition
Acute lung injury (ALI), which can progress to the highly lethal acute respiratory distress syndrome (ARDS), remains a condition with limited pharmacological interventions, highlighting the urgent need for mechanism-informed repurposing strategies. Given the reported inhibitory effects of digoxin…
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Fecal DNA SDC2 methylation test for colorectal cancer diagnosis: A systematic review and meta-analysis
Fecal DNA methylation of the syndecan-2 (SDC2) gene is being explored as a noninvasive biomarker for colorectal cancer (CRC) detection. However, its diagnostic performance necessitates thorough evaluation. A systematic search of PubMed, Embase, and Web of Science was conducted to identify studies…
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Advanced immunotherapy across diseases and the role of artificial intelligence: A review
Immunotherapy, a therapeutic strategy aimed at modulating the host immune system, has undergone rapid evolution over recent decades, particularly in oncology. Advanced methodologies, including immune checkpoint inhibition, cytokine therapy, chimeric antigen receptor T-cell therapy (CAR-T), and…
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Virtual screening of marine coumarins and xanthenes identifies novel acid-suppressive leads targeting histamine H₂ receptor and gastric proton pump
Marine natural products represent a diverse collection of structurally distinct metabolites, many of which have untapped therapeutic potential. This study screened 161 marine-derived coumarin and xanthene compounds for their binding affinity to the histamine H₂ receptor and the gastric…
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Synergistic effect of the rifaximin–berberine combination against Klebsiella pneumoniae: RfaH targeting supported by MD simulation
The escalating crisis of antimicrobial resistance (AMR) among Gram-negative pathogens, particularly Klebsiella pneumoniae (KP), necessitates innovative strategies to enhance the efficacy of existing antibiotics. Synergistic drug combinations present a promising approach to improve therapeutic…
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The role of PAQR3 in cancer progression – Molecular regulation, signaling pathways, and clinical implications: A review
Progesterone and adiponectin receptor 3 (PAQR3) is a Golgi-localized seven-transmembrane protein that anchors rapidly accelerated fibrosarcoma kinase (Raf) and suppresses rat sarcoma/rapidly accelerated fibrosarcoma/mitogen-activated protein kinase kinase/extracellular signal-regulated kinase…
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Pretreatment comprehensive nutritional index predicts survival in locally advanced rectal cancer after neoadjuvant chemoradiotherapy and surgery
Nutritional status significantly influences treatment tolerance and long-term outcomes in patients with locally advanced rectal cancer (LARC); however, individual nutritional markers may not fully capture overall nutritional reserves. This study aimed to evaluate the prognostic value of a…
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Whole-exome sequencing in obstructive coronary artery disease identifies rare and novel variants in cardiac arrhythmia and pulmonary arterial hypertension–associated genes
Coronary artery disease (CAD) represents a complex interplay of genetic, environmental, and lifestyle factors. In this study, we utilized whole-exome sequencing (WES) on 28 patients with obstructive CAD to identify rare variants that may influence clinical outcomes beyond conventional…
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Tubeless uniportal VATS in thoracic surgery – Indications, ERAS pathways, and outcomes: A review
Tubeless uniportal video-assisted thoracoscopic surgery (VATS) is an innovative approach characterized by the use of non-intubated (spontaneous-breathing) anesthesia, the omission of routine postoperative chest drainage, and single-port access. This technique has gained traction in recent years for…
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Mechanistic insights into psoriasis and type 2 diabetes mellitus comorbidity – Implications for treatment: A review
Psoriasis is a chronic systemic inflammatory disease primarily affecting the skin, yet it is increasingly recognized for its systemic implications, particularly its strong association with type 2 diabetes mellitus (T2DM). This review synthesizes recent mechanistic and clinical evidence to elucidate…
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Prediabetes and the risk of incident chronic kidney disease in adults: A systematic review and meta-analysis
The relationship between prediabetes and chronic kidney disease (CKD) remains ambiguous, with varying results across cohort studies. This meta-analysis aimed to assess whether prediabetes is linked to an increased risk of developing incident CKD in the general adult population. A comprehensive…
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